Large multicystic ovaries in a young girl with severe hypothyroidism - an unusual association

Isher, Harpreet Kour; Kaur, Gurmandeep; Bajwa, Sukhwinder Kaur; Singh, Anita; Goraya, Santprakash S

doi:10.4038/sljog.v34i3.4885

Cited by 2 publications

(2 citation statements)

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“…High TSH could produce FSH and LH-like activity leading to luteinized ovarian cysts. 2 The current and most widely accepted theory is that high levels TSH act on FSH receptors because of the molecular similarities between the two hormones. This mechanism, known as "specificity spill over," has been demonstrated in vitro.…”

Section: Discussionmentioning

confidence: 99%

Van Wyk Grumbach syndrome - a rare association of a common prepubertal condition

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Van Wyk Grumbach syndrome - a rare association of a common prepubertal condition

et al. 2016

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“…[18] Prof. Rajiv R Mahendru [19] reported a case, which he claims to be apparently the first case of its kind in the medical literature where an 11-year-old prepubescent girl who had co-existent presence of hypothyroidism and multiple large ovarian cysts not only had remarkable improvement in her physical appearance with conservative management with L-thyroxine alone, but also had disappearance of her large ovarian cysts without the need of any surgical intervention, whatsoever. In a case study done by Harpreet Kour Isher et al, [20] they reported a 21year-old unmarried female with large multicystic ovaries. On further evaluation, they found that the patient had severe hypothyroidism.…”

Section: Introductionmentioning

confidence: 99%

Incidence of Ovarian Cyst in Hypothyroidism: An Institutional Study

Ramesan¹,

Unnikrishnan²,

Firozbabu³

2016

jebmh

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BACKGROUND Primary hypothyroidism is the decrease in production and secretion of thyroid hormones by the thyroid gland. This is characterised by slackening of metabolism and leading to multiple system impairment. The important aetiological factors for primary hypothyroidism are congenital, iodine deficiency, autoimmune thyroiditis and iatrogenic. [1] Ovarian cysts are a common cause for gynaecological surgeries. The aetiology [2] of ovarian cysts can vary greatly including benign or malignant tumours, endometriosis and inflammation, etc. However, some cysts are direct result of endocrine disorders and do not require surgery. Hypothyroidism may cause reproductive and endocrinological disorders as well. The aetiopathogenesis is complex. In 1960 Van Wyk and Grumbach first described the relation between ovarian cyst and hypothyroidism. They proposed that there was a hormonal overlap in the pituitary feedback mechanism. It is due to the fact that TSH, GH, FSH and LH are all glycoproteins with a common alpha chain and may thus cross react. High TSH could produce FSH and LH like activity leading to luteinised ovarian cyst. The TRH may also act on pituitary cells to stimulate gonadotropin release and hence FSH and LH. Other postulated mechanisms are increased ovarian sensitivity to gonadotropins, altered metabolism of oestrogen, hypothalamopituitary dysfunction and altered prolactin metabolism. AIMS To study the percentage of ovarian cyst among the diagnosed cases of primary hypothyroidism and then to find out the association between hypothyroidism and ovarian cyst. To study the relation between level of TSH and size of ovarian cyst. To study the percentage of ovarian cyst among patients with TSH <50 mIU/L between 50-100 and >100 mIU/L separately.

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Large multicystic ovaries in a young girl with severe hypothyroidism - an unusual association

Cited by 2 publications

References 7 publications

Van Wyk Grumbach syndrome - a rare association of a common prepubertal condition

Van Wyk Grumbach syndrome - a rare association of a common prepubertal condition

Incidence of Ovarian Cyst in Hypothyroidism: An Institutional Study

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