Large myxofibrosarcoma of oral cavity: A rare clinical presentation in lower gingivobuccal sulcus

Abstract

a b s t r a c tMyxofibrosarcoma occurs frequently in the extremities of older individuals and is rarely reported in the head and neck sites. The present case is a rare clinical presentation with respect to site, size and origin of the tumour. Occurring at an intraoral site, the tumour was 8 cm × 7 cm × 5.5 cm in dimensions. Myxofibrosarcoma is known to originate from subcutaneous tissues in the majority of the cases. The origin of the tumour was ambiguous in the current case, as it appeared entirely intraorally.The tumour was resected with adequate margin and following which post-operative adjuvant radiotherapy was given.

Myxofibrosarcoma of the Maxillary Sinus

“…MFS is a fibroblast-derived soft-tissue sarcoma that is frequently found in the extremities and trunk of elderly individuals but rarely encountered in the head and neck region. 1 , 2 MFS was known as a myxoid variant of malignant fibrous histiocytoma but was declassified as such by the World Health Organization in 2002 and is now recognized as a distinct pathologic entity. Malignant fibrous histiocytomas that are predominantly myxoid (>50%), without myogenic, lipoblastic, and chondrogenic features rendered a separate diagnosis of MFS.…”

“…Although MFS is a common sarcoma in the extremities, trunk, and retroperitoneum of elderly patients between the sixth and eighth decade of life, it is rare in the head and neck region. 1 , 2 Sarcomas of the head and neck account for <1% of head and neck malignancies, with only a few cases of MFS reported in this region. 3 To our knowledge, there have only been three reported cases of MFS in the maxillary sinus, with this being the fourth.…”