Large optic discs in large eyes, small optic discs in small eyes

Papastathopoulos, K I; Jonas, Jost B.

doi:10.1016/s0014-4835(05)80102-2

Cited by 29 publications

(14 citation statements)

References 7 publications

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“…It fits with the notion that within non‐highly individuals (i.e. individuals with an axial length of less than 26.5 mm or a myopic refractive error of less than −8 diopters), then eyes with longer horizontal and vertical globe diameters have a larger retinal surface area, more retinal photoreceptors, retinal pigment epithelium cells and retinal ganglion cell axons, a larger optic disc and a larger cornea . It is also in agreement with a previous study in which eyes with primary macrodiscs as compared with eyes with normal‐sized optic nerve heads had significantly larger and flatter corneas .…”

Section: Discussionsupporting

confidence: 89%

Corneal diameter and associated parameters in Chinese children: the Shandong Children Eye Study

Jiang

et al. 2016

Clinical Exper Ophthalmology

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In 4 to 18-year-old children, larger corneal diameter was associated most strongly with flatter corneal curvature, followed by longer axial length and male gender. Corneal diameter was independent of age beyond an age of 4 years. Abnormally large and abnormally small corneas may be defined as being ≥12.76 and ≤11.24 mm in diameter, respectively. Corneal diameter was not correlated with time spent indoors/outdoors.

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Section: Discussionsupporting

confidence: 89%

Corneal diameter and associated parameters in Chinese children: the Shandong Children Eye Study

Jiang

et al. 2016

Clinical Exper Ophthalmology

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“…It can be postulated that the association between optic disc size and size of the globe, as observed in a post mortem study, may have an influence. 33 In that study, optic disc size was related to horizontal and vertical globe diameters, in addition to axial length. In small globes, compared with large eyes, the vitreous body is firmer, with a lower prevalence of posterior vitreous detachment.…”

Section: Discussionmentioning

confidence: 86%

Five-Year Incidence of Age-related Macular Degeneration

You¹,

Xu²,

Yang³

et al. 2012

Ophthalmology

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“…Lempert's reasoning assumes equal photoreceptor density in hyperopic and myopic eyes. This concept has been indirectly verified by several histopathologic studies that have demonstrated increased retinal photoreceptor and nerve fiber counts in eyes with larger optic discs 26-28. In addition, large optic discs have been correlated with larger AL 19, 20.…”

Section: Discussionmentioning

confidence: 75%

“…“Pure” etiologies of amblyopia (especially strabismic) are rarer than those with combined strabismus and anisometropia28, and therefore are difficult to enroll in significant numbers for studies. The current group of amblyopic subjects was recruited over multiple years from an academic practice specializing in pediatric ophthalmology and strabismus, and has the merit of reflecting a realistic clinical sample of amblyopic patients.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Abnormalities of Optic Nerve Size and Eye Shape in Unilateral Amblyopia

Pineles

Demer

2009

American Journal of Ophthalmology

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Purpose To evaluate the optic nerve (ON) size and globe shape in amblyopic eyes using high resolution magnetic resonance imaging (MRI), and to compare these values to the sound fellow eye and normal control eyes. Design Prospective case control study Methods Thirty-four amblyopic patients and 60 normal control patients were evaluated using surface coil MRI. Retrobulbar ON cross section, maximum globe cross section, globe non-circularity (globe major axis/minor axis), axial length (AL), and the ratio of AL to ON (AL/ON) were measured. Results Corrected logmar acuity of all 34 amblyopic eyes averaged 0.43±0.30. Mean retrobulbar optic nerve cross section was 9.7±2.4 mm2, 9.5±2.3 mm2, and 10.7±2.6 mm2 for amblyopic, fellow, and normal ONs, respectively. While amblyopic and fellow ONs had similar cross sections, both were significantly (p=0.02) subnormal. AL/ON was 2.7±1.2 mm-1, 2.7±1.0 mm-1, and 2.3±0.5 mm-1, respectively. While AL/ON significantly exceeded normal in amblyopic eyes (p=0.01), there was no significant difference between amblyopic and fellow eyes. Globe non-circularity of amblyopic (1.17±0.07, p=0.002) and fellow eyes (1.15±0.04, p<0.001) was significantly greater than control (1.11±0.04), but amblyopic and fellow eyes did not differ significantly. Conclusions Unilateral amblyopia is associated with bilaterally but subclinically hypoplastic ONs, greater than normal AL/ON, and abnormally non-circular globe cross section. These factors evidently do not determine which of the two eyes will become amblyopic. Reduced circularity of amblyopic and fellow eyes may reflect optical causes of amblyopia, or bilateral dysregulation of globe shape secondary to amblyopia.

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Large optic discs in large eyes, small optic discs in small eyes

Cited by 29 publications

References 7 publications

Corneal diameter and associated parameters in Chinese children: the Shandong Children Eye Study

Corneal diameter and associated parameters in Chinese children: the Shandong Children Eye Study

Five-Year Incidence of Age-related Macular Degeneration

Bilateral Abnormalities of Optic Nerve Size and Eye Shape in Unilateral Amblyopia

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