Large, Papillomatous, Pedunculated Nevus Sebaceus: A New Phenotype

Abstract

We present five cases of an unusual phenotype of nevus sebaceus characterized by large, pink, exophytic nodules. In all cases, no evidence of extracutaneous disease or associated syndromes was observed. We review the clinical presentation of nevus sebaceus, the differential diagnosis of exophytic scalp tumors in the newborn, as well as management of these lesions.

Large, papillomatous and pedunculated nevus sebaceus

“…No evidence of extracutaneous lesions was detected in our patient nor any of the five patients reported by Correale et al. 2 …”

“…However, partial or complete surgical excision may be indicated considering the cosmesis and avoidance of possible infections from trauma, especially in the case of large lesions of NS as in our patient and the ones reported by Correale et al. 2 …”

“…In 2008, Correale et al. 2 reported a new phenotype characterized by large, pedunculated or verrucous, pink nodules or tumors in newborns. Herein, we report a new case manifesting a large, exophytic, cerebriform tumor at birth.…”

Multiple Nevus Sebaceous Occurring on the Scalp and on the Contralateral Side of the Face

“…However, it may be multiple and extensive, similar to verrucous epidermal nevi. Cases of multiple extensive NS, in which multiple NS never crossed the anterior sagittal midline, were reported by Correale and colleagues9. And a case of multiple NS located on both sides of the body has not been reported yet in the English literature.…”

Prenatal diagnosis of exophytic nevus sebaceous of the scalp

“…No other anomalies were noted, and the fetal biometry was appropriate for gestational age. The appearance of the tumors was compared with previously published cases of tumors of the scalp in neonates, as we were unable to find any similar case reported in the prenatal literature. Our case presented morphological characteristics that were very similar to exophytic nevus sebaceous (NS) described in neonates.…”