Infective endocarditis (IE) is a condition that predominantly affects native or prosthetic heart valves, currently on the rise due to the increase in invasive cardiology procedures, such as cardiac implantable electronic devices (CIED), and transcatheter interventions. 2D transthoracic echocardiography (2D TTE) and 2D transesophageal echocardiography (2D TEE) are the recommended imaging tests for diagnosis. However, these modalities present limitations in detecting vegetations and estimating their dimensions, which are overcome by three-dimensional transesophageal echocardiography (3D TEE), particularly with the multiplanar reconstruction (MPR) tool that allows us to have infinite valve planes, and thus optimize the detection of lesions and precise measurements. Additionally, the realism of the volume rendering illustrates the anatomical relationship of the lesions, useful for surgical planning. In this review, we aim to discuss the role of this recent imaging modality in the diagnosis, prognosis, and therapeutic planning of IE. Finally, we present a collection of images that illustrate the use of 3D TEE tools.