Persistent dry winter events over the eastern Mediterranean (EM) disrupt the rainy (winter) season precipitation patterns and dramatically reduce water availability in the region. Here we objectively identify persistent dry, warm winter events over Israel, and apply a Lagrangian approach to three case-studies, aiming to understand the relation between the synoptic setting, precursor Rossby waves, and how the dry, warm conditions emerge. Self-organizing map classification of atmospheric profile data over Israel shows that the most persistent (at least 5 days) dry and warm winter events are induced by a stagnant upper tropospheric ridge over the EM, a pronounced trough or cut-off low over the western/central Mediterranean and blocking over the North Atlantic. The leading mechanisms of the warm and dry conditions are: adiabatic heating during slantwise subsidence, heating by sensible heat fluxes from the surface, and advection of warm and dry continental air. The relative contributions of the mechanisms and geographical locations of the back trajectories vary greatly both within and among the events. In addition, the Atlantic blocking and EM ridge are supported by upstream diabatic heating in warm conveyor belts of North Atlantic cyclones and Mediterranean cyclones, respectively. A quantitative classification of the back trajectories above the Atlantic and the Mediterranean has shown transitions from adiabatic to diabatic contributions and vice versa along these paths. The sequential relation between Atlantic ridge (or block), trough over Europe and ridge over EM and/or west Russia places local persistent warm and dry extremes into a large-scale context and thus provides new opportunities for understanding their predictability at weather and climate scales.