Large-scale genome-wide association studies reveal the genetic causal etiology between air pollutants and autoimmune diseases
Jie Wen,
Jingwei Zhang,
Hao Zhang
et al.
Abstract:Background
Epidemiological evidence links a close correlation between long-term exposure to air pollutants and autoimmune diseases, while the causality remained unknown.
Methods
Two-sample Mendelian randomization (TSMR) was used to investigate the role of PM10, PM2.5, NO2, and NOX (N = 423,796–456,380) in 15 autoimmune diseases (N = 14,890–314,995) using data from large European GWASs including UKB, FINNGEN, IMSGC, and IPSCSG. Multivariable Mendeli… Show more
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