Large-Scale Hot Spot Engineering for Quantitative SERS at the Single-Molecule Scale

Chen, Hung-Ying; Lin, Ming‐Yuan; Wang, Chun-Yuan; Chang, Yu‐Ming; Gwo, Shangjr

doi:10.1021/jacs.5b09111

Cited by 354 publications

(285 citation statements)

References 38 publications

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“…Furthermore, self-assembly techniques are used to position plasmonic particles into a hierarchical matrix of complex sensing regimes. DNA-driven assembly or self-assembly of monodisperse particles enables the control of nanoscale positioning and the distance between plasmonic nanoparticles and plasmonic hot spots [13,42,52,53,55]. Figure 3C shows an image of the co-assembly of monodisperse Au nanoparticles with Fe 3 O 4 nanoparticles which grants controllable spacing and plasmonic coupling of the Au nanoparticles determined by the crystal structure of the resulting binary nanoparticle superlattice (A) High-resolution TEM image of sub-5-nm Pd nanoparticles after DNA-assisted assembly on a Au nanorod.…”

Section: New Plasmonic Materials Combinationsmentioning

confidence: 99%

“…Illustrations of assembly, the SERS detection hot zone, and finite-difference timedomain simulated field patterns are present. Adapted from [53]. [52].…”

Section: New Plasmonic Materials Combinationsmentioning

confidence: 99%

“…Techniques to control distance and spacing of the hot spots are essential in large-area, quantitative SERS. The strong enhancement of single hot spots may lead to a false representation of the sample when the signal is mainly determined by a few detection sites [53]. Nanoparticle superlattices have shown the potential to counterbalance the inhomogeneous distribution of sensing hot spots and enhance the detection and performance of the sensor ( Figure 3D) [53].…”

Section: New Plasmonic Materials Combinationsmentioning

confidence: 99%

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Advances in optoplasmonic sensors – combining optical nano/microcavities and photonic crystals with plasmonic nanostructures and nanoparticles

et al. 2017

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Nanophotonic device building blocks, such as optical nano/microcavities and plasmonic nanostructures, lie at the forefront of sensing and spectrometry of trace biological and chemical substances. A new class of nanophotonic architecture has emerged by combining optically resonant dielectric nano/microcavities with plasmonically resonant metal nanostructures to enable detection at the nanoscale with extraordinary sensitivity. Initial demonstrations include single-molecule detection and even single-ion sensing. The coupled photonic-plasmonic resonator system promises a leap forward in the nanoscale analysis of physical, chemical, and biological entities. These optoplasmonic sensor structures could be the centrepiece of miniaturised analytical laboratories, on a chip, with detection capabilities that are beyond the current state of the art. In this paper, we review this burgeoning field of optoplasmonic biosensors. We first focus on the state of the art in nanoplasmonic sensor structures, high quality factor optical microcavities, and photonic crystals separately before proceeding to an outline of the most recent advances in hybrid sensor systems. We discuss the physics of this modality in brief and each of its underlying parts, then the prospects as well as challenges when integrating dielectric nano/microcavities with metal nanostructures. In Section 5, we hint to possible future applications of optoplasmonic sensing platforms which offer many degrees of freedom towards biomedical diagnostics at the level of single molecules.

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Section: New Plasmonic Materials Combinationsmentioning

confidence: 99%

“…Illustrations of assembly, the SERS detection hot zone, and finite-difference timedomain simulated field patterns are present. Adapted from [53]. [52].…”

Section: New Plasmonic Materials Combinationsmentioning

confidence: 99%

Section: New Plasmonic Materials Combinationsmentioning

confidence: 99%

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Advances in optoplasmonic sensors – combining optical nano/microcavities and photonic crystals with plasmonic nanostructures and nanoparticles

et al. 2017

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“…To achieve signal uniformity and reproducibility, large-area ordered nanostructures are desirable. Periodic nanostructure arrays on solid substrates have been developed using self-assembly, [63][64][65][66][67][68][69] electrodeposition, [70][71][72][73] template-assisted fabrication, [74][75][76][77][78][79][80][81][82][83][84][85][86][87][88][89] lithography, 70,[90][91][92][93][94][95] and skeletonassisted methods. [96][97][98][99][100][101][102][103][104][105] Resonance with excitation light.-When LSPR band is overlapped the wavelength of the excitation light, that is, the plasmon is in resonance with the excitation light, it can enhance SERS activity.…”

mentioning

confidence: 99%

Review—Surface-Enhanced Raman Scattering Sensors for Food Safety and Environmental Monitoring

Tang

Zhu

Meng

et al. 2018

J. Electrochem. Soc.

165

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This article gives a review of surface-enhanced Raman scattering (SERS) sensors for food safety and environmental pollution monitoring. It introduces the basic concepts of SERS substrates, SERS enhancement factors and mechanisms, SERS probes/labels, molecular recognition elements as well as optofluidic SERS devices (SERS sensors integrated with microfluidics). This article places an emphasis on the design strategies of various SERS sensors by utilizing fingerprinting SERS spectra or by using SERS probes. It highlights the applications of SERS sensors in detection of heavy metals (such as Hg 2+ , Pb 2+ , Cd 2+ and As 3+ ), inorganic anions (nitrite, nitrate, perchlorate and fluoride), toxic small molecules (polycyclic aromatic hydrocarbon, polychlorinated biphenyls, herbicides, pesticides, antibiotics and food additives), as well as pathogens (bacteria and viruses Food safety and environment pollution are among great challenges in the human society. There are some common pollutants in the environment and food, such as heavy metals, nitrites, phosphates, pesticides, herbicides, antibiotics, hormone, pathogens and other additives. Some pollutants initially are released into the environment, and then accumulate in the food chain, and enter human bodies. Uptake of pollutants by human poses a threat to human health to different extents. 1,2Hence it is essential to monitor pollutants in the environment and food. Currently pollutants are typically measured with various laboratorybased techniques, such as atomic absorption spectroscopy, atomic fluorescence spectrometry, X-ray fluorescence spectrum, inductively coupled plasma and ion-coupled plasma-mass spectroscopy, mass spectrometry, chromatography, capillary electrophoresis, analytical profile index (API), polymerase chain reaction (PCR), and enzymelinked immunosorbent assay (ELISA).3-7 Although these techniques have high sensitivity and accuracy, they rely on expensive instruments and require professional to treat samples and operate instruments in centralized laboratories. Additionally, analysis generally takes several hours to days. For example, 0.024 ppb of Hg 2+ and 0.023 ppb of As 3+ in drinking water can be detected using atomic absorption spectroscopy with a two-step electrothermal atomizer and hydride generation atomic fluorescence spectrometry, respectively. 8,9 However, they need multiple sample preconcentration processing and expensive instruments. PCR can improve the number of the target while ELISA can produce amplified recognition signal, which could both improve the detection sensitivity to pathogens. For example, oligonucleotide microarray with combination of CdSe/ZnS quantum dots as fluorescent labels shown high specificity and sensitivity of 10 colony forming units (CFU)/mL. 10 However, the complicated procedures are very time-consuming, and the method is also vulnerable to contamination. These laboratory-based techniques cannot meet the critical need of rapid on-site measurement of pollutants. Therefore, it is essential to develop portable sensors f...

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“…36,37 Furthermore, both on-chip nonlinear optical systems and quantitative SERS call for uniformly hot surfaces with precisely engineered plasmonic properties. 35,38 The recent developments in plasmonic metasurfaces can fulfill these requirements. In general, plasmonic metasurfaces can be designed and implemented by using arrays of subwavelength-spaced plasmonic "meta-atoms" (building blocks), including onedimensional (1D) metallic nanostructures (e.g., nanoslits, nanogrooves, nanoribs), two-dimensional (2D) metallic nanostructures (nanoholes, nanoprotrusions, nanoantennas, splitring resonators), and colloidal metal nanocrystals supported on solid substrates or embedded in optical films.…”

mentioning

confidence: 99%

Plasmonic Metasurfaces for Nonlinear Optics and Quantitative SERS

et al. 2016

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Plasmonic metasurfaces consist of two-dimensional arrays of metallic nanoresonators (plasmonic "metaatoms"), which exhibit collective and tunable resonance properties controlled by electromagnetic near-field coupling. These man-made surfaces can produce a range of unique optical properties unattainable with natural materials. In this review, we focus on the emerging applications of metasurfaces with precisely engineered plasmonic properties for nonlinear optics and surface-enhanced Raman spectroscopy (SERS). In practice, these applications are quite susceptible to material losses and structural imperfections, such as variations in size, shape, periodicity of meta-atoms, and their material states (crystallinity, impurity, and oxidation, etc.). In these aspects, conventional top-down lithographic techniques are facing major challenges due to inherent limitations in intrinsic material properties and material quality introduced during growth, synthesis, and fabrication processes, as well as achievable lithographic resolution. Moreover, they are prohibitively expensive and timeconsuming for fabrication over large areas. Here, we show that colloidal silver crystals (millimeter-sized single-crystalline plates and thiolate-capped nanoparticles) synthesized by solution-based chemical methods are excellent material platforms for the fabrication of high-quality plasmonic metasurfaces. In particular, both top-down (focused ion-beam milling) and bottom-up (centimeter-scale self-assembly) techniques can be exploited to generate uniform and precisely engineered colloidal metasurfaces for broadband tunable (across the full visible range) second-harmonic generation and quantitative SERS at the single-molecule level.

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Large-Scale Hot Spot Engineering for Quantitative SERS at the Single-Molecule Scale

Cited by 354 publications

References 38 publications

Advances in optoplasmonic sensors – combining optical nano/microcavities and photonic crystals with plasmonic nanostructures and nanoparticles

Advances in optoplasmonic sensors – combining optical nano/microcavities and photonic crystals with plasmonic nanostructures and nanoparticles

Review—Surface-Enhanced Raman Scattering Sensors for Food Safety and Environmental Monitoring

Plasmonic Metasurfaces for Nonlinear Optics and Quantitative SERS

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