The coupling of scientific evidence from sediment cores with historical information represents an effective way to reconstruct and quantify recent anthropogenic impacts in transitional and marine-coastal areas. These are both key points pertaining to studies that aim at establishing the responsibility for envi ronmental pollution. Good practices for the selection of sampling sites and specific survey techniques are fundamental to understand pollution histories and dynamics, together with reliable dating methods and analytical procedures. In addition, a certain degree of flexibility and willingness to explore different research pathways is necessary, particularly when unexpected questions arise from scientific data or from requests posed by authorities in charge of preliminary investigations or court debates. In this paper, two different study cases are reviewed, and the approaches developed to tackle with specific issues are presented. Its main purpose is both to explain study paths undertaken to answer challenging scientific-legal questions and to provide examples for developing countries that present similar risks of uncontrolled industrialization. Results were used in preliminary investigations or court debates for the attribution of responsibility for environmental pollution to past or present industrial managements. In addition, they were fundamental for other studies aiming at implementing models that simulate the fate and distribution of contaminants and human exposure. In the Augusta Harbor, an integrated approach merged archive information, bathymetry, and high-resolution seismic profiles with the results of an independent tracer (hexachlorobenzene, HCB). This approach helped attribute the presence of high surficial Hg concentrations to resuspension and redistribution of deep sediments caused by dredging and maritime traffic and not to active outfalls. In the Venice Lagoon, an extensive literature search supported analytical results for the correct identification of industrial processes responsible for the contamination by polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs) in the canals of the Porto Marghera Industrial Area. In addition, sedimentary profiles of PCDD/Fs in local salt marshes (“barene”) recorded well the events relative to the industrial development and management of the area reported by historical documents, confirming their potential for this kind of investigation.