Large-scale meta-analysis of genetic studies in ischemic stroke: Five genes involving 152,797 individuals

Abstract

BACKGROUND:Ischemic stroke descent has a genetic basis. Stroke represents a complex trait, which is assumed to be polygenic. On this topic, the role of a wide number of candidate genes has been investigated in stroke through association studies.MATERIALS AND METHODS:We performed a literature-based systematic review of genetic association studies in stroke abound several populations. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined for each gene-disease association. Following a review of 300 manuscripts, five candidate gene variants were analyzed among 152,797 individuals (45,433 cases and 107,364 controls).RESULTS:For these five candidate genes studied, the prothrombin OR is 1,57 (1,23-2,89), the factor V Leiden OR is 1,43 (0,67-6,24), the mean OR of angiotensin I converting enzyme (ACE) insertion/deletion (I/D) polymorphism is 1,11 (1,02-1,25), the summary OR for the C677T variant of 5,10-methylenetetrahydrofolate reductase (MTHFR) is 1,23 (0,61-1,47) and the pooled OR for the apolipoprotein E (APOE) gene is 0,95 (0,77-1,14) .CONCLUSION:These data suggest the genetic associations of some genes with ischemic stroke and it is necessary to compete with other genes. Our findings could represent an epidemiological base and a useful tool to address further molecular investigations and to realize more detailed meta-analyses.

A plasma proteomics method reveals links between ischemic stroke and MTHFR C677T genotype

“…Hamzi K., et al . performed a meta-analysis, which revealed that prothrombin and MTHFR were risk factors in Indian patients with ischemic stroke 31 . CIS protein is important for the complement cascade and plays a role in the regulation of immune adhesion 32 .…”

Spontaneous Bilateral Vertebral Artery Dissection Secondary to PAI-1, MTHFR C677T and ACE Gene Mutations in a Young Man

“…One third occur in patients younger than 65 years [3]. Etiologies include atrial fibrillation with embolization [3], hypertension, diabetes mellitus, cervicocerebral stenosis [1,2,4], cerebral venous thrombosis [5] and a hypercoaguable state [4,5,6,7,8,9]. …”

“…The most frequent candidate polymorphism associated with the risk of cerebral stroke include ACE, factor V Leiden, MTHFR, prothrombin G20210A and apolipoprotein E [8]. The thrombogenic risk factor increases with the cumulative existence of the variant mutations: the gene-dose effect [6,9].…”

Association of methylenetetrahydrofolate reductase gene (C677T) with the risk of hypertension in Morocco

“…A recent study showed that supplementation with Riboflavin in hypertensive patients carrying the homozygous genotype mutant 677TT of MTHFR, without other cardiovascular diseases, has considerably improved the value of systolic blood pressure, paving the way for personalized medicine [ 16 ]. It is worth noting, that numerous studies investigated the relationship between the C677T polymorphism of MTHFR and many diseases, including breast cancer [ 17 , 18 ], colorectal cancer [ 19 ], ischemic stroke [ 20 , 21 ], inflammatory bowel disease [ 22 ] and hypertension [ 7 , 23 , 24 ]. In the light of the limited data on the variants of the MTHFR and hypertension in our population, and the role of vitamin B2 in the improvement of blood pressure in hypertensive patients with a mutant variant of the MTHFR gene, this case–control study was carried out to investigate the association of 677C > T polymorphism of MTHFR with the risk of hypertension in a sample of the Moroccan population.…”