We combine COBE DMR measurements of cosmic microwave background (CMB) anisotropy with a recent measurement of the mass power spectrum at redshift z \ 2.5 from Lya forest data to derive constraints on cosmological parameters and test the inÑationary cold dark matter (CDM) scenario of structure formation. By treating the inÑationary spectral index n as a free parameter, we are able to Ðnd successful Ðts to the COBE and Lya forest constraints in models with and without massive neu-) m \ 1 trinos and in models with and without a cosmological constant. Within each class of model, the low-) m combination of COBE and the Lya forest P(k) constrains a parameter combination of the form with di †erent indices for each case. This new constraint breaks some of the degeneracies in ) m hanb) b c, cosmological parameter determinations from other measurements of large-scale structure and CMB anisotropy. The Lya forest P(k) provides the Ðrst measurement of the slope of the linear mass power spectrum on DMpc scales, l \ [2.25^0.18, and it conÐrms a basic prediction of the inÑationary CDM scenario : an approximately scale invariant spectrum of primeval Ñuctuations (n B 1) modulated by a transfer function that bends P(k) toward kn~4 on small scales. Considering additional observational data, we Ðnd that COBE-normalized, models that match the Lya forest P(k) do not match the ) m \ 1 observed masses of rich galaxy clusters, and that models with a cosmological constant provide low-) m the best overall Ðt to the available data, even without the direct evidence for cosmic acceleration from Type Ia supernovae. With our Ðducial parameter choices, the Ñat, models that match COBE and low-) m the Lya forest P(k) also match recent measurements of small-scale CMB anisotropy. Modest improvements in the Lya forest P(k) measurement could greatly restrict the allowable region of parameter space for CDM models, constrain the contribution of tensor Ñuctuations to CMB anisotropy, and achieve a more stringent test of the current consensus model of structure formation.