2024
DOI: 10.1101/2024.02.17.580698
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Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue

Rebecca Andrews,
Bin Fu,
Christina E. Toomey
et al.

Abstract: Parkinson's disease (PD) is a common neurodegenerative condition characterised by the presence in the brain of large intraneuronal aggregates, known as Lewy bodies and Lewy neurites, containing fibrillar α-synuclein. According to the amyloid hypothesis, these large end-stage species form from smaller soluble protein assemblies, often termed oligomers, which are proposed as early drivers of pathogenesis. To date, however, this hypothesis has remained controversial, at least in part because it has not been possi… Show more

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