Large Solitary Fibrous Tumor (SFT) of the penis- a case report and review of literature

Abstract

Background Solitary fibrous tumors (SFTs) are very rare spindle cell neoplasms of mesenchymal origin with largely benign course of disease. Genital SFT’s can be managed providing excellent functional and psychological outcomes by timely intervention. Case presentation We report the largest and possibly the second only reported case of penile SFT in a 34 year male presenting with a gradually increasing perineal mass with clinically normal appearing phallus. MRI revealed a 9.8 × 3.2 cm soft tissue mass arising from left corpora cavernosae, the mass was excised en-bloc via a perineal approach under spinal anaesthesia. Histopathology revealed spindle cell tumor embedded in myxohyaline stroma along with hyalinized vascular channels demonstrating IHC positivity for CD34 and STAT6. The patient is disease free post 2 years of resection with no sexual or urinary dysfunctions. Conclusion Genital SFTs, although rare, should be considered in the differential diagnosis of well-circumscribed, painless, slow growing solid masses and histopathologists must be vigilant of its malignant characteristics.

Exploring Solitary Fibrous Tumors at a Tertiary Cancer Center: Clinicopathological and Immunomorphologic Profile

“…Other neoplasms such as spindle cell lipoma, well- and dedifferentiated liposarcoma (WDL/DDL), and angiofibroma to name a few can also complicate the diagnostic quandaries concerning SFTs, as discussed in Table 10 . In fact, given the aforementioned diagnostic pitfalls and the ambiguous nature of the histopathological characteristics of SFTs, Jain et al advance a step further to emphasize the appraisal of SFTs by experienced soft tissue pathologists [ 38 ]. Nonetheless, a pertinent point the authors wish to underline here is that at unusual sites for SFTs, the more familiar entities at those locations should be verily excluded before proffering a diagnosis of SFT.…”