Large Ultrathin Shelled Drops Produced via Non‐Confined Microfluidics

Chaurasia, Ankur; Josephides, Dimitris N.; Sajjadi, Shahriar

doi:10.1002/cphc.201402606

Cited by 11 publications

(19 citation statements)

References 31 publications

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“…It is very difficult to fabricate a double-emulsion drop with an ultra-thin shell less than several hundred nanometers using classic capillary microfluidic devices. There have been some configurations of capillary microfluidics to fabricate such ultra-thin-shell double-emulsion drops and microcapsules [36][37][38][39][40][41][42]. For example, an ultra-thin middle layer of double-emulsion drops can be stably created by squeezing a thin layer of middle fluid between the inner wall of the capillary and the innermost fluid [36].…”

Section: Introductionmentioning

confidence: 99%

Generation of Ultra-Thin-Shell Microcapsules Using Osmolarity-Controlled Swelling Method

Guo

Hou

et al. 2020

Micromachines

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Microcapsules are attractive core-shell configurations for studies of controlled release, biomolecular sensing, artificial microbial environments, and spherical film buckling. However, the production of microcapsules with ultra-thin shells remains a challenge. Here we develop a simple and practical osmolarity-controlled swelling method for the mass production of monodisperse microcapsules with ultra-thin shells via water-in-oil-in-water (W/O/W) double-emulsion drops templating. The size and shell thickness of the double-emulsion drops are precisely tuned by changing the osmotic pressure between the inner cores and the suspending medium, indicating the practicability and effectiveness of this swelling method in tuning the shell thickness of double-emulsion drops and the resultant microcapsules. This method enables the production of microcapsules even with an ultra-thin shell less than hundreds of nanometers, which overcomes the difficulty in producing ultra-thin-shell microcapsules using the classic microfluidic emulsion technologies. In addition, the ultra-thin-shell microcapsules can maintain their intact spherical shape for up to 1 year without rupturing in our long-term observation. We believe that the osmolarity-controlled swelling method will be useful in generating ultra-thin-shell polydimethylsiloxane (PDMS) microcapsules for long-term encapsulation, and for thin film folding, buckling and rupturing investigation.

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Section: Introductionmentioning

confidence: 99%

Generation of Ultra-Thin-Shell Microcapsules Using Osmolarity-Controlled Swelling Method

Guo

Hou

et al. 2020

Micromachines

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“…The resulting fibers were collected at the top of the cuvette, facilitated by the buoyancy force exerted by the encapsulated oil. This buoyancy‐assisted nonconfined microfluidic device has previously been used to generate millimetric core–shell drops . A high‐speed video recording camera (Photron FastCam SA‐5 (monochrome)) was used to record the fiber formation.…”

Section: Methodsmentioning

confidence: 99%

“…This buoyancy-assisted nonconfi ned microfl uidic device has previously been used to generate millimetric core-shell drops. [ 23,24 ] A high-speed video recording camera (Photron FastCam SA-5 (monochrome)) was used to record the fi ber formation.…”

Section: Methodsmentioning

confidence: 99%

Flexible Asymmetric Encapsulation for Dehydration‐Responsive Hybrid Microfibers

Chaurasia

Sajjadi

2016

Small

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A new class of smart alginate microfibers with asymmetric oil encapsulates is introduced. These fibers are produced by injecting an aqueous alginate solution into an outer aqueous calcium chloride solution to form alginate fibers, which are asymmetrically loaded with oil entities through eccentrically aligned inner capillaries. The fiber morphology and its degree of asymmetry can be tuned via altering the size, location, and frequency of the oil encapsulates. These asymmetric fibers reveal significant potential for applications where conventional symmetric fibers fail to perform. It is shown how asymmetric oil-encapsulated fibers can become dehydration-sensitive, and trigger the release of encapsulates if their hydration level drops below a critical value. It is also shown how the triggered response could be switched off on demand by stabilizing the oil encapsulates. The capability of asymmetric fibers to carry and release multiple cargos in parallel is demonstrated. The fibers loaded with equal-sized spheres are more asymmetric than those containing unequal drops, have a higher tensile strength, and show better potential for a triggered response.

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“…The formed fibers were collected at the top of the cuvette, facilitated by the buoyancy force exerted by the encapsulated oil. This buoyancy-assisted microfluidic setup has previously been used to produce 4 dehydration-responsive oil-loaded alginate microfibers [20], and to generate millimetric core-shell drops with tunable shell thickness [21,22]. A high-speed video recording camera (Photron FastCam SA-5 monochrome) was used to record fiber formation.…”

Section: Device and Proceduresmentioning

confidence: 99%

“…We have previously used a similar model to predict the droplet size in a buoyancy assisted co-flow systems [21,22]. However, the significance of the current system is that the viscosity of alginate phase varies with time, which is hard to predict.…”

Section: Size Estimation and Analysismentioning

confidence: 99%

Flexible microfluidic fabrication of oil-encapsulated alginate microfibers

Chaurasia

Jahanzad

Sajjadi

2017

Chemical Engineering Journal

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A unified microfluidic approach is presented for flexible fabrication of oil-encapsulated calcium alginate microfibers. The oil encapsulate phase was directly injected into the gelling alginate fiber, thus allowing the adjustable tuning of the encapsulate geometry ranging from spherical to prolate ellipsoid, plug-like and tubular shapes. Phase maps were developed that show the conditions required to achieve desired fiber morphologies with intended encapsulate phase ratio. We also show for very first time how oil encapsulates can be selectively grouped across the microfibers. A force-balance model, validated against a non-gelling system, was introduced to predict the size of spherical encapsulates.

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Large Ultrathin Shelled Drops Produced via Non‐Confined Microfluidics

Cited by 11 publications

References 31 publications

Generation of Ultra-Thin-Shell Microcapsules Using Osmolarity-Controlled Swelling Method

Generation of Ultra-Thin-Shell Microcapsules Using Osmolarity-Controlled Swelling Method

Flexible Asymmetric Encapsulation for Dehydration‐Responsive Hybrid Microfibers

Flexible microfluidic fabrication of oil-encapsulated alginate microfibers

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