Larger and near-term baby retinopathy: a rare case series

Padhi, Tapas Ranjan; Rath, Suryasnata; Jalali, Subhadra; Pradhan, Lingaraj; Kesarwani, Siddharth; Nayak, M. M.; Mishra, Biswajit; Panda, Krushna Gopal; Suttar, S

doi:10.1038/eye.2014.253

Cited by 10 publications

(8 citation statements)

References 7 publications

(4 reference statements)

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“…This was nearly similar to our previous report on term and near term baby retinopathy. 11 The cystic fovea seen in these babies has not been reported by any of the 3 other newborn screening studies analyzed in this report though, some other studies have reported similar transient macular cysts documented in SDOCT in healthy infants. [12][13][14] In fact, we have seen similar finding in 6 babies screened for ROP under a separate project (unpublished data).…”

Section: Resultssupporting

confidence: 49%

Outcome of universal newborn eye screening with wide-field digital retinal image acquisition system: a pilot study

Goyal

Padhi

Das

et al. 2017

Eye

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PurposeTo evaluate the outcome of universal newborn eye screening with wide-field digital retinal imaging (WFDRI) system.MethodsIn this pilot study, we examined 1152 apparently healthy newborn infants in the obstetrics and gynecology ward of a civil hospital in Eastern India over 1.5 years. The examination included external eye examination, red reflex test and fundus imaging by WFDRI (RetCam II, Clarity medical system, Pleasanton, CA, USA) by a trained optometrist. The pathologies detected, net monetary gain and skilled manpower saved were documented. The results were compared with three similar studies thus far published in the literature.ResultsOcular abnormality of any kind was seen in 172 (14.93%) babies. Retinal hemorrhage in 153 babies (88.9% of all abnormal findings) was the most common abnormality; it was bilateral in 118 (77.12%) babies and 4 babies had foveal hemorrhage. Other abnormalities included vitreous hemorrhage (n=1), congenital glaucoma (n=2), uveal coloboma (n=2), retinopathy mimicking retinopathy of prematurity (n=2), and cystic fovea (n=3). The retinal hemorrhages resolved spontaneously in all eyes. One baby with congenital glaucoma received surgery and the other was treated medically. The benefits included savings in skilled manpower, a net monetary gain of INR 4.195 million (US$ 62,612) and skilled manpower saving by 319.4 h.ConclusionsThe universal neonatal eye screening using WFDRI detected pathologies that needed immediate care or regular follow up; saved skilled manpower with a net monetary gain. But compared to a red reflex test the benefits were marginal in terms of detecting treatment warranting ocular pathologies.

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Section: Resultssupporting

confidence: 49%

Outcome of universal newborn eye screening with wide-field digital retinal image acquisition system: a pilot study

Goyal

Padhi

Das

et al. 2017

Eye

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“…Retinal vascular changes similar to ROP in healthy full/nearterm infants with a normal birth weight were sporadically reported in previous studies (5,7). And among them, most of infants were with supplementary oxygen exposure.…”

Section: Discussionmentioning

confidence: 71%

“…In full term infants, retinopathies can occur with clinical features that can appear similar to ROP (4)(5)(6). ROP-like retinopathies (ROPLR) refers to ROP developing in full/near-term neonates at a birth weight heavier than 2400 g (7). Some potential risk factors, such as brain anomalies and defects and poor maternal nutrition, increased oxygen tension in the retina after birth, hypoxic-ischemic encephalopathy (HIE) and family exudative vitreoretinopathy (FEVR) were suspected to be related to the occurrence of ROPLR (8,9).…”

Section: Introductionmentioning

confidence: 99%

ROP-like retinopathy in full/near-term newborns: A etiology, risk factors, clinical and genetic characteristics, prognosis and management

et al. 2022

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PurposeRetinopathy of prematurity (ROP) like retinopathy (ROPLR) could occur in full/near-term newborns. The causes and clinical features are still largely elusive. This study focused on the risk factors, clinical and genetic characteristics, treatment and outcome, and prognosis of ROPLR.MethodsA total of 47 consecutive full/near-term newborns during 2016–2017 with ROPLR were included. The clinical and genetic characteristics, treatment and outcome, prognosis, and potential underlying etiology of ROPLR were were analyzed.Results91 eyes of 47 infants were found to have ROPLR. The ROPLR regressed completely in 65.9% and partially in 20.9% of eyes without any interventions. Retinal changes of family exudative vitreoretinopathy (FEVR) were allocated in 12 neonates (group A), perinatal hypoxia-ischemia were categorized in 17 neonates (group B), and the other 18 neonates were categorized in group C. Compared to those in group B/C, infants in group A had significantly more severe retinopathy (stage 4/5, p < 0.001) and more treatments (p < 0.00 risk factor 1).ConclusionsPerinatal hypoxia-ischemia might be a major risk factor for ROPLR, in which spontaneous regression was common. FEVR, confirmed by positive family findings and genetic testing, might be the second risk factor of ROPLR, in which retinopathy is more severe and treatment is needed.

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“…The infant in our case had a GA of 35 weeks and BW of 1700 g. Studies from several parts of the world have reported that larger premature infants who received improper oxygen therapy can develop ROP [ 11 , 12 ]. Our case has already been diagnosed with TOF at birth and required supplemental oxygen administration due to systemic hypoxia.…”

Section: Discussionmentioning

confidence: 87%

“…A reason for the development of retinal vascular abnormalities in TOF has been suggested to be ischemia. In general, oxygen saturation of the arterial blood cannot be maintained in infants with a CCHD; therefore an ischemic environment of the body arises [ 11 ]. The role of hypoxia has been demonstrated to be associated with nonperfused peripheral retina in animal models [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Persistence of Retinopathy of Prematurity in an Infant with Tetralogy of Fallot

Günay

Yavuz

Çelik

et al. 2016

Case Reports in Pediatrics

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We report an infant with tetralogy of fallot (TOF) who was born at 35 weeks of gestation and of 1700 g birth weight and presented with persistent retinopathy of prematurity (ROP) at 6 months of age. Follow-up ophthalmic examinations were done at 2, 3, and 4 weeks of age. A demarcation line in Zone II was noticed on the first ocular examination done at 4 weeks of postnatal age. At 6 months of postnatal age, the infant still had an avascular peripheral retina with the demarcation line in Zone II. Even though this index subject did not have any typical risk factors for ROP, TOF seems to be the probable reason for developing as well as persistence of avascular retina.

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Larger and near-term baby retinopathy: a rare case series

Cited by 10 publications

References 7 publications

Outcome of universal newborn eye screening with wide-field digital retinal image acquisition system: a pilot study

Outcome of universal newborn eye screening with wide-field digital retinal image acquisition system: a pilot study

ROP-like retinopathy in full/near-term newborns: A etiology, risk factors, clinical and genetic characteristics, prognosis and management

Persistence of Retinopathy of Prematurity in an Infant with Tetralogy of Fallot

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