Bootstrap percolation is a deterministic cellular automaton in which vertices of a graph G begin in one of two states, “dormant” or “active.” Given a fixed positive integer r, a dormant vertex becomes active if at any stage it has at least r active neighbors, and it remains active for the duration of the process. Given an initial set of active vertices A, we say that G r‐percolates (from A) if every vertex in G becomes active after some number of steps. Let m(G,r) denote the minimum size of a set A such that G r‐percolates from A. Bootstrap percolation has been studied in a number of settings and has applications to both statistical physics and discrete epidemiology. Here, we are concerned with degree‐based density conditions that ensure m(G,2)=2. In particular, we give an Ore‐type degree sum result that states that if a graph G satisfies σ2(G)≥n−2, then either m(G,2)=2 or G is in one of a small number of classes of exceptional graphs. (Here, σ2(G) is the minimum sum of degrees of two nonadjacent vertices in G.) We also give a Chvátal‐type degree condition: If G is a graph with degree sequence d1≤d2≤⋯≤dn such that di≥i+1 or dn−i≥n−i−1 for all 1≤i