Larvicidal activity of the naphthylisoquinoline alkaloid dioncophylline A against the malaria vector Anopheles stephensi

François, Guido; Looveren, M. Van; Timperman, G.; Chimanuka, Bantuzeko; Ake-Assi, L.; Holenz, Jörg; Bringmann, Gerhard

doi:10.1016/s0378-8741(96)01459-6

Cited by 37 publications

(27 citation statements)

References 9 publications

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“…The air-dried and pulverized roots (500 g) of R. leptopetala were washed with 20% (v/v) aqueous NH 4 (1) was also isolated from the methanol extract (18.5 g) of the roots (500 g), which was obtained by extraction of roots with cold MeOH for 72 h at room temperature. This material was chromatographed on a silica gel column (63-200 µm, Vetec) using hexane, CHCl 3 , EtOAc and MeOH as eluents.…”

Section: Extraction and Isolation Of Liriodenine (1)mentioning

confidence: 99%

“…This is not an easy task because the mosquitoes have developed resistance to the current synthetic insecticides that, in addition, are toxic to humans and the environment. The mosquito population control in the larval stage is much easier than in the adult [4][5][6][7][8] which motivated our group to search for new insecticides from Brazilian plants.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have focused on natural products as insecticides for controlling A. aegypti larvae. Alkaloids and essential oils from herbal plants have demonstrated larvicidal activity, [4][5][6][7][8] which motivated our group to search for new insecticides from Brazilian plants.Rollinia leptopetala R. E. Fries, popularly known as pinha brava, is an endemic shrub in Brazil and shows strong toxicity when eaten by animals. 9 The phytochemical investigation of Rollinia species has been reported in the literature revealing acetogenins, steroids, lignans and alkaloids, as secondary metabolites.…”

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Chemical composition and larvicidal activity of Rollinia leptopetala (Annonaceae)

Feitosa

Arriaga

Conceição

et al. 2009

J. Braz. Chem. Soc.

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No presente trabalho descreve-se a composição química dos óleos essenciais de Rollinia leptopetala R.E. Fries (Annonaceae) e as atividades larvicidas dos óleos essenciais, do extrato metanólico das raízes desta espécie e do alcalóide oxoaporfinico, liriodenina (1), frente às larvas no terceiro estágio do mosquito Aedes aegypti. O extrato metanólico mostrou-se ativo com CL 50 64,6 ± 1,5 ppm e uma forte atividade foi exibida para o composto (1), CL 50 3,6 ± 0,4 ppm. Os óleos essenciais das folhas e galhos também mostraram atividade com CL 50 104,7 ± 0,2 and 34,7 ± 0,3 ppm, respectivamente. Estes dados sugerem que R. leptopetala é fonte potencial de larvicidas naturais. A composição química do óleo essencial e as atividades descritas são comunicadas pela primeira vez.The aim of present study was to describe the chemical composition of the essential oils from the leaf and stem of Rollinia leptopetala R. E. Fries (Annonaceae) and to evaluate the larvicidal activities of these essential oils, of the methanol extract from roots of this plant and of the oxoaporphine alkaloid, liriodenine (1) against the third-instar of Aedes aegypti larvae. The methanol extract from the roots showed larvicidal activity with LC 50 64.6 ± 1.5 ppm. Higher activity was observed for the isolated alkaloid liriodenine (1), LC 50 3.6 ± 0.4 ppm. The essential oils from the leaves and stems, also exhibited larvicidal activity with LC 50 104.7 ± 0.2 and 34.7 ± 0.3 ppm, respectively. These results suggest R. leptopetala as a source of natural larvicidal compounds. This is the first report about the chemical composition and larvicidal activity of the leaf and stem essential oils of R. leptopetala. Keywords: Rollinia leptopetala, Annonaceae, essential oils, liriodenine, Aedes aegypti IntroductionAedes aegypti is the principal mosquito vector of dengue fever, including the hemorrhagic form, which is endemic to South East Asia, Central and South America, and West Africa.1 Between 50 and 100 million of cases are registered each year, causing thousands of deaths. 2The disease has high levels of mortality, and also inflicts great economic losses and social disruption in Brazil. Although some viral diseases, such as yellow fever, have been brought reasonably under control with a vaccine, no vaccine is so far available for dengue. Today, the only way of decreasing the incidence of this disease is by controlling the Aedes aegypti proliferation. This is not an easy task because the mosquitoes have developed resistance to the current synthetic insecticides that, in addition, are toxic to humans and the environment. The mosquito population control in the larval stage is much easier than in the adult Chemical Composition and Larvicidal Activity of Rollinia leptopetala (Annonaceae) J. Braz. Chem. Soc. 376 stage, and then new strategies are needed for controlling the proliferation of the larvae of A. aegypti. Several studies have focused on natural products as insecticides for controlling A. aegypti larvae. Alkaloids and essential oils from herbal plants have ...

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Section: Extraction and Isolation Of Liriodenine (1)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Chemical composition and larvicidal activity of Rollinia leptopetala (Annonaceae)

Feitosa

Arriaga

Conceição

et al. 2009

J. Braz. Chem. Soc.

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“…stephensi with LD 50 values of 0.5, 1.0 and 2.0 mg/L at 3.33, 2.66 and 1.92 h, respectively. In each instar larval stage, the LC 50 values decrease as a function of time indicating that 135 continues to exert its action during at least 48 h (Franqois et al 1996).…”

Section: Naphthylisoquinoline Alkaloidmentioning

confidence: 99%

Natural products as leads to potential mosquitocides

et al. 2013

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Mosquitoes are the crucial vectors for a number of mosquito-borne infectious diseases i.e. dengue, yellow fever, chikungunya, malaria, Rift Valley fever, elephantiasis, Japanese Encephalitis, and Murray Valley encephalitis etc. Besides, they also transmit numerous arboviruses (arthropod-borne viruses) for example West Nile virus (WNV), Saint Louis encephalitis virus, Eastern equine encephalomyelitis virus (EEE), Everglades virus (EVEV), Highlands J (HJ) virus, and La Crosse Encephalitis virus. The emergence of widespread insecticide resistance and the potential environmental issues associated with some synthetic insecticides (such as DDT) has indicated that additional approaches to control the proliferation of mosquito population would be an urgent priority research. The present review highlights some natural product mosquitocides that are target-specific, biodegradable, environmentally safe, and botanicals in origin.

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Tolerance of Aedes aegypti larvae to triorganotins

Nguyen

Ogwuru

Eng

2000

Appl. Organometal. Chem.

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The effects of triorganotins on the 4th instar stage of Aedes aegypti larvae were evaluated. The most effective of the 15 triorganotins used in the study was tributyltin chloride with an LC 50 value of 0.57 AE 0.07 mg dm À3 . The low LC 50 values obtained indicated that this class of compounds is an effective larvicide against the larvae of this species of mosquito. The toxicity of the compounds was found to be primarily dependent on the R group attached to the tin atom. The order of activity for the triorganotins tested was Bu b Ph b Cy b Me. However, a limited order, based on two series of the compounds tested, was also observed for the anionic X group on the tin atom.

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Larvicidal activity of the naphthylisoquinoline alkaloid dioncophylline A against the malaria vector Anopheles stephensi

Cited by 37 publications

References 9 publications

Chemical composition and larvicidal activity of Rollinia leptopetala (Annonaceae)

Chemical composition and larvicidal activity of Rollinia leptopetala (Annonaceae)

Natural products as leads to potential mosquitocides

Tolerance of Aedes aegypti larvae to triorganotins

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