Laryngeal Botryoid Rhabdomyosarcoma in an Adult

Balázs, M; Egerszegi, P.

doi:10.1016/s0344-0338(89)80174-8

Cited by 7 publications

(1 citation statement)

References 13 publications

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“…Iso form CK-1 has been considered to be a tumor marker for several carcinomas [7][8][9], and es pecially for disseminated métastasés from Rhabdomyosarcomas are tumors charac terized by rhabdomyoblastic differentation and aggressive behavior [1]. The diagnosis of this tumor involves the use of electron mi croscopy [2], conventional histopathology [3], and currently, immunohistochemical techniques such as indirect immunofluores cence, alkaline phosphatase, and peroxidase antiperoxidase [4], Myoglobin, desmin, vimentin and other myofilament proteins have been studied as potential markers of rhabdo myoblastic differentation [5], In our search for a purely immunological marker of rhab domyoblastic tumors, we analyzed class-I and class-II major histocompatibility com these tumors. Another form of this enzyme, designated macrocreatine kinase (MCK), has been discovered on the mitochondrial mem brane of heart, liver and brain cells [9].…”

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confidence: 99%

Detection of Creatine Kinase Isoenzymes as Tumoral Markers of Rhabdomyosarcoma

Fernández¹,

Rodrı́guez²,

Recio³

et al. 1992

Enzyme

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We analyzed the expression profile of isoenzymatic fractions of creatine phosphokinase (EC 2.13.2) isotypes MM, MB and BB in three cell lines derived from embryonic rhabdomyosarcomas and a normal counterpart cell line. Electrophoretic data showed that the BB fraction was consistently expressed de novo, in contrast with its counterpart in normal tissue. The BB fraction may serve as new tumoral marker for the diagnosis of rhabdomyosarcoma. In addition, the apperance of macrocreatine kinase type-1 in this type of neoplasm may serve to reinforce the diagnosis when rhabdomyosarcoma is suspected.

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Section: Introductionmentioning

confidence: 99%

Detection of Creatine Kinase Isoenzymes as Tumoral Markers of Rhabdomyosarcoma

Fernández¹,

Rodrı́guez²,

Recio³

et al. 1992

Enzyme

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Juvenile (embryonal and alveolar) rhabdomyosarcoma of the head and neck in adults. A clinical, pathologic, and immunohistochemical study of 12 cases

Nakhleh

Swanson

Dehner

1991

Cancer

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Sites in the head and neck region (orbit, nasopharynx, nasal cavity, etc.) are among the most frequent locations for juvenile (embryonal and alveolar) rhabdomyosarcomas in patients younger than 15 years; however, comparable neoplasms in adults are very uncommon. A clinicopathologic and immunohistochemical study of 12 juvenile rhabdomyosarcomas in patients between the ages of 18 and 36 years is presented. There was a female:male ratio of 2:1. The orbit with or without contiguous paranasal sinus involvement, nasal cavity, sphenoid sinus, middle ear, and soft tissues of the neck and preauricular region were the primary sites. Seven tumors involved a parameningeal site and eight cases were alveolar rhabdomyosarcomas which together contributed to the adverse outcome. Only two patients were long-term, disease-free survivors. Six patients have died of tumor and two others are alive with persistent disease. Immunohistochemical study in 11 cases demonstrated reactivity for vimentin and muscle-specific actin (HHF-35) and desmin in ten cases. Juvenile rhabdomyosarcoma rarely presents in the head and neck of adults but should be considered in the differential diagnosis of a small cell neoplasm in patients during the third and fourth decades of life.

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Larynx

Burkhardt¹,

Meyer-Breiting²

1999

Spezielle Pathologische Anatomie

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Laryngeal Botryoid Rhabdomyosarcoma in an Adult

Cited by 7 publications

References 13 publications

Detection of Creatine Kinase Isoenzymes as Tumoral Markers of Rhabdomyosarcoma

Detection of Creatine Kinase Isoenzymes as Tumoral Markers of Rhabdomyosarcoma

Juvenile (embryonal and alveolar) rhabdomyosarcoma of the head and neck in adults. A clinical, pathologic, and immunohistochemical study of 12 cases

Larynx

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