Laryngeal Cancer: Diagnosis and Preoperative Work-up

Chu, Eugene A.; Kim, Young Jin

doi:10.1016/j.otc.2008.01.016

Cited by 219 publications

(170 citation statements)

References 41 publications

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“…Laryngeal carcinoma is the second most common malignancy in the head and neck region (Chu et al, 2008). Except for invasion and metastasis, multidrug resistance (MDR) is a major reason related to the failure of treatment in human laryngeal cancer.…”

Section: Introductionmentioning

confidence: 99%

Hypoxia Induced Multidrug Resistance of Laryngeal Cancer Cells via Hypoxia-inducible Factor-1α

Li¹,

Dong²,

Wang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Introductionmentioning

confidence: 99%

Hypoxia Induced Multidrug Resistance of Laryngeal Cancer Cells via Hypoxia-inducible Factor-1α

Li¹,

Dong²,

Wang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Larynx cancer (LCa), being an aggressive malignancy, is the second most commonly diagnosed malignant type of head and neck squamous cell carcinoma worldwide [1] and it is estimated to constitute approximately 1% (13,360) of incident cancer cases in 2017 in the United States alone. It is also predicted to constitute an important fraction of cancer deaths with 3,660 attributed cases in 2017 [2].…”

Section: Introductionmentioning

confidence: 99%

Current cancer stem cell biomarkers in laryngeal cancer

Karataş¹,

Barlak²,

Şahin³

2017

The European Research Journal

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Larynx cancer (LCa), being an aggressive malignancy, is the second most commonly diagnosed malignant type of head and neck squamous cell carcinoma worldwide. Although there have been significant improvements in the detection and diagnosis of LCa in the last decades, it is still one of the considerable causes of cancer deaths and an urgent need for identification of novel biomarkers with diagnostic and prognostic significance still remains. The cancer stem cells (CSCs) resemble normal stem cells in terms of biological features and are considered to play critical roles in biological aggressiveness of tumors. Accumulating evidences have proven the existence of CSCs in various tumors including LCa and they are considered as driving force for tumor relapse, metastasis, and chemo-radioresistance. Comprehensive identification and characterization of the CSCs is of paramount importance for their further characterization to develop more effective and targeted therapeutic strategies against cancer. Here, we reviewed and summarized the most current literature to provide an insight into the functions and roles of current CSCs biomarkers in human LCa. We believe that this review will contribute to the knowledge of scientists especially working with LCa CSCs and will help understanding the significance of CSCs biomarkers implicated in LCa pathogenesis.

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“…Larenks kanserleri baş boyun bölgesinin ikinci sıklıkta görülen malign tümörleridir (1). Olguların % 30-40' ında larenksin supraglottik bölgesinde lokalizedirler (2).…”

Section: Introductionunclassified

“…Bu bölgeden kaynaklanan kanserler, zengin lenfatik drenaja sahip olmaları ve göreceli olarak geç semptom vermeleri nedeniyle sıklıkla ileri evrede saptanırlar. Prognozları glottik yerleşimli kanserlere göre daha kötüdür (1,3). Geleneksel açık cerrahi ile larenksin parsiyel ya da total rezeksiyonu ve/veya kemoradyoterapi erken evre larenks kanserinin tedavisinde kullanılan primer tedavi seçenekleridir.…”

Section: Introductionunclassified

Transoral Robotic Supraglottic Laryngectomy

Turhan¹,

Bostancı²

2016

Akd Med J

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Öz amaç:Transoral robotik cerrahi (TORC) supraglottik larenks kanserlerinin endolarengeal tedavisinde minimal invaziv yeni bir yöntemdir. Çalışmanın amacı transoral robotik supraglottik larenjektomi uyguladığımız iki hastadaki ilk tecrübelerimizi paylaşmaktır. Gereç ve Yöntemler:Erken evre (T1-2) supraglottik kanserli iki hasta TORC için seçildi. Hastaların preoperatif, intraoperatif ve postoperatif yönetimi literatür derlemesi eşliğinde sunuldu. Material and Methods:Two patients with early stage (T1-2) supraglottic cancer were selected for TORS. The preoperative, intraoperative and postoperative management of patients were presented with a literature review.Results: Laryngeal tumor tissue was resected en bloc with negative surgical margins in both patients. Patients were extubated on postoperative day one. They were decannulated and started to be fed orally on postoperative day seven. Swallowing functions were recovered completely on postoperative day 10. No perioperative or postoperative complications were observed.The first case was discharged uneventfully on postoperative day 20, and the second case on postoperative day 14. Conclusion:Transoral robotic supraglottic laryngectomy is a safe and effective treatment choice in well-selected patients with supraglottic larynx cancer. Further trials with a larger cohort of patients are needed for evaluation of long-term functional and oncological outcomes.

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Laryngeal Cancer: Diagnosis and Preoperative Work-up

Cited by 219 publications

References 41 publications

Hypoxia Induced Multidrug Resistance of Laryngeal Cancer Cells via Hypoxia-inducible Factor-1α

Hypoxia Induced Multidrug Resistance of Laryngeal Cancer Cells via Hypoxia-inducible Factor-1α

Current cancer stem cell biomarkers in laryngeal cancer

Transoral Robotic Supraglottic Laryngectomy

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