Laryngeal cancers in paediatric and young adult patients: epidemiology, biology and treatment

Lechien, Jérôme R.; Sadoughi, Babak; Hans, Stéphane

doi:10.1097/moo.0000000000000766

Cited by 7 publications

(3 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The male/female ratio ranged from 3/1 to 14/1 according to different studies, with a mean ratio of 13.8/1 [9,13–16,18]. In the laryngeal squamous cell cancer population, the male/female ratio is 6/1 and may vary substantially across world regions depending on regional alcohol and tobacco habits [2 ▪ ,3,4]. Compared with other laryngeal cancers, LVC has usually a smaller tumor size [16].…”

Section: Epidemiologymentioning

confidence: 99%

“…Head and neck squamous cell carcinomas are the sixth most common adult malignancy worldwide, corresponding to 5.3% of all cancers [1]. Laryngeal squamous cell carcinoma (LSCC) is the second most prevalent carcinoma among head and neck cancers, accounting for 211 000 new cases and 126 000 deaths per year worldwide [2 ▪ ,3,4]. Verrucous carcinoma was initially reported as a distinct variant of well differentiated SCC by Ackerman in 1948 [5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Laryngeal verrucous cell carcinoma

Lechien,

Vaira,

Chiesa-Estomba

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

Self Cite

View full text Add to dashboard Cite

Purpose of review To summarize the recent literature on epidemiology, clinical findings, treatment, and survival of laryngeal verrucous cell carcinoma (LVC). Recent findings Epidemiological studies report that LVC accounts for 1–3% of all laryngeal cancers. The incidence is decreasing, while most patients are male individuals and smokers. LVC are commonly detected in early stages because they are more frequently located in the glottic region. Tobacco, alcohol overuse, and, possibly, human papilloma virus are the main contributing factors. Recent studies confirm that surgery is the primary therapeutic approach with better prognosis when compared with other treatment modalities. Surgery alone is associated with 86.8% disease-free and 80.3% overall survival rates, while metastases are anecdotal. Summary LVC presents different clinical, pathological, and survival outcomes when compared with the classic laryngeal squamous cell carcinoma. Biopsies need often to be repeated before getting the most appropriate diagnosis; this supports the need of large-sample biopsy during the tumor diagnosis and staging. The glottic location of most LVC leads to detection of this lesion in its early stages, with ensuing better survival and outcomes after surgery compared with the classic form of squamous cell carcinoma. Future studies are needed to understand the biology of LVC and its related better prognostic outcomes when compared to other laryngeal malignancies.

show abstract

Section: Epidemiologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Laryngeal verrucous cell carcinoma

Lechien,

Vaira,

Chiesa-Estomba

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

Self Cite

View full text Add to dashboard Cite

show abstract

“…The 5-year overall survival rate for LC shows continued decline in the last few decades [ 4 ]. The occurrence of LC is multifactorial and is related to common carcinogens (tobacco and alcohol) [ 5 ]. Radiotherapy, chemotherapy, and surgical resection are the main treatments for LC, but the recurrence rate of advanced LC is 25-50%, and there are still numerous patients with poor prognosis [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

BNIPL is a promising biomarker of laryngeal cancer: novel insights from bioinformatics analysis and experimental validation

Wang,

Gao,

Wen

et al. 2024

BMC Med Genomics

View full text Add to dashboard Cite

Background Laryngeal cancer (LC) is a malignant tumor with high incidence and mortality. We aim to explore key genes as novel biomarkers to find potential target of LC in clinic diagnosis and treatment. Methods We retrieved GSE143224 and GSE84957 datasets from the Gene Expression Omnibus database to screen the differentially expressed genes (DEGs). Hub genes were identified from protein-protein interaction networks and further determined using receiver operating characteristic curves and principal component analysis. The expression of hub gene was verified by quantitative real time polymerase chain reaction. The transfection efficiency of BCL2 interacting protein like (BNIPL) was measured by western blot. Proliferation, migration, and invasion abilities were detected by Cell Counting Kit-8, wound-healing, and transwell assays, respectively. Results Total 96 overlapping DEGs were screened out from GSE143224 and GSE84957 datasets. Six hub genes (BNIPL, KRT4, IGFBP3, MMP10, MMP3, and TGFBI) were identified from PPI network. BNIPL was selected as the target gene. The receiver operating characteristic curves of BNIPL suggested that the false positive rate was 18.5% and the true positive rate was 81.5%, showing high predictive values for LC. The expression level of BNIPL was downregulated in TU212 and TU686 cells. Additionally, overexpression of BNIPL suppressed the proliferation, migration, and invasion of TU212 and TU686 cells. Conclusion BNIPL is a novel gene signature involved in LC progression, which exerts an inhibitory effect on LC development. These findings provide a novel insight into the pathogenesis of LC.

show abstract