Laryngeal carcinoma in childhood. Report of a case and review of the literature

Laurian, N.; Sadov, Rima; Strauss, Maurice B.; Kessler, E

doi:10.1288/00005537-198405000-00021

Cited by 27 publications

(23 citation statements)

References 15 publications

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“…On the other hand, we recognize that due to a small number of patients, definitive treatment recommendations cannot be made at this time. Our cases, except one, had an early diagnosis and were treated according to the same parameters we use for adults, and our results were as good as other reported cases [21][22][23]. However, the patient with advanced tumor had an extremely unfavorable evolution, which reinforces the importance of staging in the evaluation of the prognosis of these cases and the need of an early diagnosis of this rare tumor.…”

Section: Discussionsupporting

confidence: 79%

Head and neck squamous cell carcinoma in childhood

Carvalho

Sobrinho

Rapoport

et al. 1998

Med. Pediatr. Oncol.

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Background Squamous cell carcinoma (SCC) of the head and neck region is rare in young patients and even less frequent in children 15 years or younger children. The patients reported in the literature are isolated cases and their management is always difficult because there is no large experience or a convincing theory to support treatment decisions for every child. Procedures and Results. Four patients aged 15 years or younger were treated for SCC of head and neck between 1977 and 1995 at the Head and Neck Service of Heliópolis Hospital, São Paulo, Brazil, and with this paper we are reporting our experience with their treatment, including a genetic investigation in two cases (immunohistochemical analysis using monoclonal antibodies against p53 and c‐erbB‐2 oncogenes). These patients had no history of tobacco or ethanol abuse and no history of cancer in their families. Many authors attribute an unusual aggressiveness to SCC in childhood, with propensity to locoregional recurrence and high death rates and therefore, propose aggressive multidisciplinary therapy. Our cases, with the exception of one, had an early diagnosis and were treated using the same method we use for adults; the results were very good. Conclusions. We recommend for these cases the same protocol as for older patients. In these cases, however, the primary lesion is resected with a safety margin which is usually 2 to 3 mm larger than usual safety margins and selective neck dissection is routinely indicated. This management is adopted in an attempt to avoid postoperative irradiation which may prove to be dangerous in the future for young patients. On the other hand, we recognize that due to a small number de patients, definitive treatment recommendations cannot be made at this time. Med. Pediatr. Oncol. 31:96–99, 1998. © 1998 Wiley‐Liss, Inc.

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Section: Discussionsupporting

confidence: 79%

Head and neck squamous cell carcinoma in childhood

Carvalho

Sobrinho

Rapoport

et al. 1998

Med. Pediatr. Oncol.

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“…During this 12-year period when approximately 17,000 adult Lx or HP cancers were seen at our institute, only 6 (0.035%) were in the pediatric age group. Amongst the 68 children with laryngeal SCC reported in the literature [1][2][3][4][5][6][7][8][9][10][11][12], including three of the present series, various aspects of this disease, its treatment and outcome can be studied. The details are, however, not available for each reported case.…”

Section: Discussionmentioning

confidence: 99%

“…As expected from the multistep carcinogenesis model, it is very rare in children. Since 1868, only 65 cases of childhood SCC of larynx [1][2][3][4][5][6][7][8][9][10][11][12] and 2 cases of hypopharynx [11,13] have been reported, all as isolated case reports. We present the largest series of six consecutive children below the age of 16 years with laryngeal (Lx) or hypopharyngeal (HP) SCC seen at a single institute from 1989-2000.…”

mentioning

confidence: 99%

Squamous carcinoma of the larynx and hypopharynx in children: A distinct clinical entity?

Siddiqui

Sarin

Agarwal

et al. 2003

Med. Pediatr. Oncol.

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“…The prognosis of laryngeal carcinoma in adolescents is unclear because survival rates have not been reported according to tumour stage due to the scarcity of cases [10]. Recently, studies have suggested that prognosis may be affected by the presence of chromosomal translocation (15;19) or the presence of HPV DNA within the tumor cells.…”

Section: Resultsmentioning

confidence: 99%