Laryngeal Metastasis 7 Years After Radical Nephrectomy

Dee, Simpson L.; Eshghi, Majid; Otto, Clifton S

doi:10.5858/2000-124-1833-lmyarn

Cited by 20 publications

(3 citation statements)

References 8 publications

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“…This could be explained because most metastases to the larynx are through the systemic circulation, following the route of the inferior vena cava to the laryngeal artery, and through retrograde circulation of the paravertebral venous plexus or thoracic lymphatic duct10 and because the glottis and subglottis have fewer blood and lymphatic supply 11. In our case, the tumour was located to the glottis, and this has been described before only by a few articles 12–16…”

Section: Discussionmentioning

confidence: 57%

Renal cell carcinoma (RCC) spreading to the larynx: an unusual condition

Sanchez Teran,

Martínez Zamorano,

Trujillo Ortíz

et al. 2024

BMJ Case Rep

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A man in his mid-70s, heavy smoker with chronic alcohol consumption and a chronic exposure to insecticides and burning of crop residues was referred to the surgical oncology department because of a 4-month onset of hoarseness, dyspnoea and laryngeal stridor. He had a history of left nephrectomy due to Fuhrman IV clear cell renal cancer 2 years ago. The patient underwent a bronchoscopy which identified a deforming tumour of the left vallecula, occlusion of 90% of the lumen and did not allow a safe biopsy. Following discussion between the oncological team, total laryngectomy and bilateral neck dissection of levels II, III, IV and V were performed, finding a transglottic tumour of approximately 4×3 cm with extension to the right anterolateral thyroid cartilage. The pathology report described metastatic RCC. The patient recovered well postoperatively and started systemic therapy with a vascular endothelial growth factor receptors inhibitor.

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Section: Discussionmentioning

confidence: 57%

Renal cell carcinoma (RCC) spreading to the larynx: an unusual condition

Sanchez Teran,

Martínez Zamorano,

Trujillo Ortíz

et al. 2024

BMJ Case Rep

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“…Reviewing the literature we found eighteen reports of renal clear cell metastasis to the larynx. Most of those studies reported solitary metastasis to supraglottic region [9][10][11][12] , three of the studies reported solitary glottic metastasis [13][14][15] , three described Clear cell metastatic carcinoma of the larynx is an extremely rare diagnosis with low survival rate. While most patients in literature are treated with a combination of surgical and oncologic therapy, we present a case where prolonged survival was achieved in a patient who opted only for oncological treatment.…”

Section: Short Literature Reviewmentioning

confidence: 99%

Metastasis of clear cell renal cell carcinoma to the larynx

Vrebac

Braut

Velepić

et al. 2021

Med. Flum. (Online)

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Renal clear cell metastatic carcinoma of the larynx is an extremely rare diagnosis with poor survival. The objective of this short review is to provide insight into current state of literature on this rare neoplasm. Additionally we include the case of a patient with metastatic process of the thyroid cartilage that was treated with novel targeted therapies which enabled prolonged survival and good quality of life. These findings support their inclusion in treatment protocols of patients with metastatic renal clear cell carcinoma of the larynx, especially in those refusing surgery which is the main treatment option in literature so far.

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“…The lungs, liver, bones, suprarenal glands, pleura, brain, and soft tissues are among the common sites of metastasis for RCC [ 2 ]. However, isolated RCC metastases to the head and neck region, particularly the larynx, are extremely rare [ 3 ].RCC is the second most common cancer to metastasize to the larynx after skin cancer [ 4 ], and secondary tumors of the larynx account for only 0.09% to 0.4% of all laryngeal tumors [ 5 ]. As a malignant disease, RCC is a great imitator with an erratic clinical course and biological behavior.…”

Section: Introductionmentioning

confidence: 99%

Metastatic Renal Cell Carcinoma Masquerading as a Laryngeal Tumor: A Case Report

Ahmed¹,

Barik²,

Adhya³

et al. 2023

Cureus

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Renal cell carcinoma (RCC) commonly metastasizes to various organs such as the lungs, liver, bones, and brain. However, isolated metastases to the head and neck region, especially the larynx, are very rare. This report presents a case of laryngeal growth that was eventually confirmed to be a metastatic deposit from an undiagnosed RCC. We report a case of a 66-year-old male who presented to the clinic with painless neck swelling and a change in voice. The scan showed a soft tissue mass in the thyroid cartilage. Histopathology of the resected laryngeal tumor confirmed metastatic clear cell carcinoma. A metastatic workup revealed a renal mass, and the patient underwent laparoscopic adrenal-sparing left cytoreductive nephrectomy. The histopathological examination established the diagnosis of clear cell RCC. Subsequently, the patient was treated with pembrolizumab and lenvatinib. Follow-up imaging showed no residual or recurrent lesions. This case highlights the rarity of laryngeal metastasis from RCC and the importance of an accurate diagnosis through advanced imaging and histopathological examination.

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Laryngeal Metastasis 7 Years After Radical Nephrectomy

Cited by 20 publications

References 8 publications

Renal cell carcinoma (RCC) spreading to the larynx: an unusual condition

Renal cell carcinoma (RCC) spreading to the larynx: an unusual condition

Metastasis of clear cell renal cell carcinoma to the larynx

Metastatic Renal Cell Carcinoma Masquerading as a Laryngeal Tumor: A Case Report

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