Laryngeal Schwannoma: A Case Presentation and Review of the Mayo Clinic Experience

Romak, Jonathan J.; Neel, H. Bryan; Ekbom, Dale C.

doi:10.1016/j.jvoice.2015.12.003

Cited by 18 publications

(22 citation statements)

References 7 publications

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“…Among the 479 articles resulting from our literature search, 60 primary research papers fulfilled our criteria ( Figure 1 ), providing a total of 74 laryngeal schwannoma patients for combined analysis ( Table 1 and Supplemental Tables S1 and S2, available in the online version of the article). 2-61 The included studies consisted primarily of single case reports (n = 55), 4 reports of 2 cases, and 1 larger case series of 11 patients. The mean age at diagnosis was 43.4 years, with women presenting at a later age compared with men (47.3 years vs 32.8, P < .05).…”

Section: Resultsmentioning

confidence: 99%

“…1 The only known risk factors for their development are prior radiation exposure and genetic predisposition. 2 Sporadic schwannomas affect patients of all ages, including children, [2][3][4][5] reaching a peak between 20 and 50 years, with no predilection to any ethnic group. Most schwannomas occur sporadically and singly, but they may also be seen as multiple schwannomas as part of neurofibromatosis type 2 and schwannomatosis.…”

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confidence: 99%

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Diagnosis and Treatment of Laryngeal Schwannoma: A Systematic Review

Tulli

Bondi

Smart

et al. 2017

Otolaryngol.--head neck surg.

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Objective This review summarizes the clinical features, diagnostic workup, and surgical treatment of laryngeal schwannoma with the aim of providing guidance for the management of this rare disease. The collated data allowed the statistical testing of several hypotheses, including the efficacy of endoscopic vs open surgical intervention and the usefulness of preoperative biopsy. Data Sources PubMed, Google Scholar, Cochrane, and SCOPUS. Review Methods Basic epidemiological and clinical presentation data were collated together with details of diagnostic image modality, lesion attributes, and the use of preoperative biopsy. Surgical approach to intervention and outcome was also collated and simple statistical analyses applied. Results The 60 original articles selected provided a combined cohort of 74 patients for review. The combined data revealed that schwannoma with pedunculated morphology were always safely removed by endoscopic resection regardless of size and should be treated as a separate entity. Of the nonpedunculated schwannoma, larger tumors were more likely to undergo an open approach, which in turn was associated with higher rates of tracheotomy and postoperative vocal fold paralysis. The small cohort did not reveal a significant association between surgery type and persistent disease. Interestingly, the data revealed a significant association between the use of incisional biopsy and persistent disease. Cases exhibiting extralaryngeal extension of the lesion were shown to exclusively belong to patients with neurofibromatosis/schwannomatosis syndromes. Conclusions Taken together, these findings suggest that incisional biopsy should be avoided, and given the benign nature of the pathology, the least invasive radical approach should be employed.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Diagnosis and Treatment of Laryngeal Schwannoma: A Systematic Review

Tulli

Bondi

Smart

et al. 2017

Otolaryngol.--head neck surg.

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“…The vast majority of schwannomas occur as sporadical single lesions, affecting patients of all ages, but most commonly between the ages of 20 and 50, without associated lifestyle risk factors [6]. In regards of gender predilection, no general agreement is observed in literature, with some authors reporting a female predominance [7].…”

Section: Discussionmentioning

confidence: 99%

Young pregnant woman with mild dysphagia: Diagnostic and treatment workup predicting laryngeal schwannoma

Martelli¹,

Squadrelli²,

Santoro³

et al. 2019

J Syst Integr Neurosci

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Schwannomas of the larynx are uncommon, they represent the 0.1-1.5% of all the benign laryngeal tumours. Patients usually report multiple symptoms related to mass-effects and their treatment of choice is surgical excision. We present the case of a young woman presenting a schwannoma within her left false vocal fold, not suitable for endoscopic surgical approach. The suspected diagnosis of schwannoma was confirmed by the final histopathological report, showing a protein S110 positivity at the immunohistochemistry staining. Complete surgical excision is the treatment of choice and can be performed by either transoral or external approach depending on lesion dimension, patient's laryngeal exposure and surgeon's skills. In both cases we do suggest a conservative approach.

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“…Rarely, laryngeal schwannomas are found in children 141 . Within the larynx, they develop in different locations 142 143 , e. g. (most frequently) at the aryepiglottic fold and the arytenoid region ( Fig. 7 ) 144 , in the pre-epiglottic space 145 , in the paraglottic space 146 , at the false vocal cords, the vocal folds, the epiglottis, and in the subglottis.…”

Section: Benign Tumorsmentioning

confidence: 99%

“…In cases of absent functional disorders, first wait-and-scan strategy may be pursued after histological confirmation. Otherwise, therapy of choice is the surgical removal mostly via transoral microsurgery 143 but also via open approaches, partly with tracheostomy 145 . In the recent literature, reports on transoral robotic removal with the DaVinci system are found 119 147 .…”

Section: Benign Tumorsmentioning

confidence: 99%

Seltene Erkrankungen des Larynx, der Trachea und der Schilddrüse

Hackenberg¹,

Kraus²,

Scherzad³

2021

Laryngorhinootologie

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ZusammenfassungDer Übersichtsartikel beinhaltet eine Zusammenstellung seltener Erkrankungen von Larynx, Trachea und Schilddrüse. Im Speziellen werden angeborene Fehlbildungen, seltene Formen der entzündlichen Larynxerkrankungen, gutartige und bösartige epitheliale sowie nicht-epitheliale Tumoren, laryngeale und tracheale Manifestationen von Allgemeinerkrankungen und schließlich seltene Erkrankungen der Schilddrüse besprochen. Die einzelnen Kapitel beinhalten eine Übersicht über die Datenlage in der Literatur, das jeweilige klinische Erscheinungsbild, wichtige Stichpunkte zur Diagnostik und zur Therapie und eine abschließende Stellungnahme zur Prognose der Erkrankung. Des Weiteren finden sich Hinweise zu Studienregistern und Selbsthilfegruppen.

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Laryngeal Schwannoma: A Case Presentation and Review of the Mayo Clinic Experience

Cited by 18 publications

References 7 publications

Diagnosis and Treatment of Laryngeal Schwannoma: A Systematic Review

Diagnosis and Treatment of Laryngeal Schwannoma: A Systematic Review

Young pregnant woman with mild dysphagia: Diagnostic and treatment workup predicting laryngeal schwannoma

Seltene Erkrankungen des Larynx, der Trachea und der Schilddrüse

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