Laryngectomy Complications Are Associated with Perioperative Antibiotic Choice

Langerman, Alexander; Ham, Sandra A.; Pisano, Jennifer; Pariser, Joseph J.; Hohmann, Samuel F.; Meltzer, David O.

doi:10.1177/0194599815583641

Cited by 36 publications

(65 citation statements)

References 24 publications

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“…Previous studies have similarly suggested an increased risk of recipient surgical site infections with prophylactic clindamycin compared to ampicillin‐sulbactam in clean‐contaminated head and neck cases, although this association was not demonstrated in all studies . Surgical site infections in head and neck clean‐contaminated cases are often polymicrobial and can include gram‐negative aerobic bacteria (eg, Escherichia coli , Klebsiella pneumoniae , or Pseudomonas aeruginosa ) for which clindamycin does not offer coverage .…”

Section: Discussionmentioning

confidence: 90%

Antibiotic prophylaxis in clean‐contaminated head and neck cases with microvascular free flap reconstruction: A systematic review and meta‐analysis

et al. 2017

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Section: Discussionmentioning

confidence: 90%

Antibiotic prophylaxis in clean‐contaminated head and neck cases with microvascular free flap reconstruction: A systematic review and meta‐analysis

et al. 2017

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“…Both organisms are listed as CDC major health threats and have the capability to colonize the skin, respiratory tract, and prosthetic material used for surgical revision or infusion of IV chemotherapy agents (eg, tracheostomy or indwelling central venous catheters) . Although the incidence of these organisms in SSI is questionable or underreported, the perceived risk and detrimental effects these organisms have on patient outcomes contribute to antibiotic misuse by clinicians …”

Section: Statementsmentioning

confidence: 99%

Systematic review of international guidelines for perioperative antibiotic prophylaxis in Head & Neck Surgery. A YO‐IFOS Head & Neck Study Group Position Paper

et al. 2019

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Background Surgical site infection (SSI) is defined as an infection that occurs after a surgical incision or organ manipulation during surgery. The frequency reported for clean head and neck surgical procedures without antimicrobial prophylaxis is <1%. In contrast, infection rates in patients undergoing complicated cancer surgery are high, ranging from 24% to 87% of patients without antimicrobial prophylaxis. Methods Guidelines and recommendations about the use of antibiotics in head and neck surgery from 2004 to 2019 were reviewed. Results Four guidelines from Oceania, 5 from South America, 5 from North America, 2 from the United Kingdom, 11 from Europe, 1 from Africa, 1 from the Middle East, and 3 from Asia were included. A total of 118 papers were included for analysis and recommendation. Conclusion Antibiotic prophylaxis can decrease the incidence of SSI. However, the risks associated with antibiotic exposure and the risk of antibiotic resistance need to be taken into consideration.

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“…However, antibiotic overuse has become increasingly recognized as a major driving force in the development of global antimicrobial resistance . Moreover, overuse of antibiotics leads to increased healthcare costs and can result in negative consequences to an individual patient including Clostridium difficile infection, renal toxicity, allergic reactions, and rarely, anaphylaxis …”

Section: Introductionmentioning

confidence: 99%

Are Perioperative Antibiotics Necessary During Direct Microlaryngoscopy?

et al. 2018

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Objectives/Hypothesis There are currently no established recommendations for the use of perioperative antibiotics (PAs) to prevent surgical site infections (SSIs) for direct microlaryngoscopy (DML). This study examined the incidence of SSI in patients undergoing DML with and without PAs. Study Design Retrospective, multi‐institutional chart review. Methods A retrospective, multi‐institutional chart review was performed at four tertiary referral academic medical centers. Patients undergoing DML from 2010 to 2017 were identified using Current Procedural Terminology codes. Medical records of patients undergoing DML with biopsy, microsurgery, laser ablation, or vocal fold injection who had adequate follow‐up were reviewed. Procedures with significant cartilage destruction, concurrent open surgery, or esophageal surgery were excluded. Data recorded included age, gender, pacemaker history, American Society of Anesthesiologists class, wound class, indication for surgery, use of laser, complications, emergency room visits, hospitalizations, pain, fever, and postoperative steroid and antibiotic prescriptions. Presence or absence of SSIs was evaluated by a fellowship‐trained laryngologist. Results There were 834 patients who met inclusion criteria. Of those, 698 did not receive PAs and 136 received PAs. The median age of patients was 54 years of age in the PA group and 57.5 years of age in the non‐PA group, and all cases were recorded as wound class II. Overall, 58% of surgeries involved use of carbon dioxide or potassium‐titanyl‐phosphate laser. Only one SSI was reported on follow‐up in a patient who did receive PAs. Conclusions SSIs are exceedingly rare following DML. PA use is not indicated for routine DML. Level of Evidence 4 Laryngoscope, 128:2838–2843, 2018

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Laryngectomy Complications Are Associated with Perioperative Antibiotic Choice

Cited by 36 publications

References 24 publications

Antibiotic prophylaxis in clean‐contaminated head and neck cases with microvascular free flap reconstruction: A systematic review and meta‐analysis

Antibiotic prophylaxis in clean‐contaminated head and neck cases with microvascular free flap reconstruction: A systematic review and meta‐analysis

Systematic review of international guidelines for perioperative antibiotic prophylaxis in Head & Neck Surgery. A YO‐IFOS Head & Neck Study Group Position Paper

Are Perioperative Antibiotics Necessary During Direct Microlaryngoscopy?

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