Laryngitis and neutropenia from parvovirus-B19

Özbek, Özlem; Onay, Ozge Surmeli; Kinik, Sibel Tulgar; Özbek, Namık

doi:10.1007/s12098-007-0176-x

Cited by 6 publications

(4 citation statements)

References 8 publications

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“…Other syndromes for which a causative role for B19V is unclear include generalized edema (963)(964)(965)(966), myositis (967), the onset of diabetes (968) and inflammatory bowel disease (969), uveitis (970), retinal detachment (971), retinal pigment epitheliopathy (972), Rosai-Dorfman histiocytic proliferation (973), laryngitis (974), inner ear disease (975), and testicular tumors (976). B19V DNA persistence in the thyroid after previous infection may account for associations with thyroid cancer (191) and autoimmune thyroiditis (977).…”

Section: Clinical Manifestations Diseases Caused By B19v Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed. The full spectrum of parvovirus disease in humans has yet to be established. Candidate recombinant B19V vaccines have been developed but may not be commercially feasible. We review relevant features of the molecular and cellular biology of these viruses, and the human immune response that they elicit, which have allowed a deep understanding of pathophysiology.

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Section: Clinical Manifestations Diseases Caused By B19v Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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“…12,13 However, cases of neutropenia secondary to parvovirus infection have been reported in the literature. 14,15 This patient was diagnosed with typical 5. Disease rash and positive for parvovirus B19 IgM antibody.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the incidence of vitamin B12 deficiency in leukopenia and neutropenia secondary to infection

Sarbay¹

2019

Int J Contemp Pediatr

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Background: Infections and nutritional deficiencies are the most common causes of the leucopenia and neutropenia. In this study, we aimed to find the incidence of vitamin B12 deficiency in patients with leukopenia and neutropenia secondary to infection.Methods: Between September 2018 and December 2018, patients who were referred to Diyarbakır Children Hospital's Pediatric Hematology and Oncology Clinic for leukopenia and/ or neutropenia were thought to develop secondary to infection retrospectively evaluated.Results: Of the 60 patients that evaluated, 23(38.3%) were female and 37(61.7%) were male. The mean age±SD was 4.75±4.5 years. Severe neutropenia was detected in 5(8.3%), moderate neutropenia in 31(51.7%) and mild neutropenia in 17(28.3%) patients. Neutrophil counts were within normal limits in 7(11.7%) patients. When vitamin B12 levels were examined, 17(28.3%) patients had B12 deficiency.Conclusions: Investigation and treatment of vitamin B12 deficiency in patients with leukopenia and neutropenia may shorten the duration of cytopenia and prevent the development of secondary complications.

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“…He had a respiratory rate of 56 breaths per minute and a temperature of 39°C, and sepsis was thus diagnosed. 24 Four cases did not meet the definition of SIRS, 18,20,22,23 and the reports of the remaining 6 cases had no clinical information on SIRS diagnosis. 2,17,19,21 Therefore, existing evidence is insufficient for determining how often sepsis or sepsislike syndrome develops in infants.…”

Section: Discussionmentioning

confidence: 99%

Parvovirus B19: A Cause of Sepsislike Syndrome in an Infant

Ugai¹,

Aizawa

Kanayama³

et al. 2018

Pediatrics

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Parvovirus B19 (PB19) is an important human pathogen that results in a wide spectrum of clinical outcomes, from mild, self-limiting erythema infectiosum in immunocompetent children and arthralgia in adults to lethal cytopenia in immunocompromised patients and intrauterine fetal death. However, there have been few reports of PB19 infection in neonates or young infants (aged 28-90 days), and no previous reports contained descriptions of PB19 infection as a cause of sepsislike syndrome in this age group. We report a case of sepsislike syndrome caused by PB19 infection in a 56-day-old infant whose mother had polyarthralgia at the time of his admission. PB19 infection was diagnosed on the basis of positive polymerase chain reaction results for PB19 DNA in the serum and cerebrospinal fluid. Positive immunoglobulin M and negative immunoglobulin G for PB19 suggested acute infection. He was admitted to the ICU because of poor peripheral circulation, but fully recovered without antibiotic administration. After excluding other possible pathogens, PB19 should be suspected as a cause of sepsislike syndrome in young infants, especially those who have close contact with PB19-infected individuals.

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Laryngitis and neutropenia from parvovirus-B19

Cited by 6 publications

References 8 publications

Human Parvoviruses

Human Parvoviruses

Investigation of the incidence of vitamin B12 deficiency in leukopenia and neutropenia secondary to infection

Parvovirus B19: A Cause of Sepsislike Syndrome in an Infant

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