Laryngopharyngeal reflux concept: what is known and what should we focus on?

Şirin, Seher; Öz, Ferhan

doi:10.1016/j.bjorl.2019.01.001

Cited by 10 publications

(11 citation statements)

References 10 publications

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“…Laryngopharyngeal reflux (LPR) differs from classic gastroesophageal reflux (GER) in various aspects and has been recognized as an independent clinical entity [ 1 ]. These aspects include pathologic mechanisms, symptoms of disease, clinical appearance and therapeutic response [ 2 ]. In general, GER presents with lower esophageal sphincter insufficiency, whereas LPR additionally shows a dysfunction of the upper esophageal sphincter [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Value of Transnasal Esophagoscopy in the Workup of Laryngo-Pharyngeal Reflux

Horvath

Fostiropoulos

Burri

et al. 2021

JCM

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Background: Laryngopharyngeal reflux (LPR) can display a variety of symptoms, and upper endoscopy is occasionally used for its investigation. The aim of the present study was to determine the value of transnasal esophagoscopy (TNE) in the workup of LPR. Methods: In 200 consecutive patients with suspected LPR, reflux symptom index (RSI), reflux finding score (RFS), oropharyngeal pH-monitoring (PHM) and transnasal esophagoscopy (TNE) were carried out and rated according to the Horvath Score. Results: In the investigation of LPR, TNE showed a sensitivity, specificity and accuracy of 96%, 85% and 95%, respectively. The most common pathologic TNE findings in LPR patients were an insufficient cardia, hiatal hernia, lymphoid follicles and visible reflux. Conclusions: TNE is a supportive method in the workup of LPR, which can display the underlying pathology and directly affect therapeutic decisions.

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Section: Introductionmentioning

confidence: 99%

Value of Transnasal Esophagoscopy in the Workup of Laryngo-Pharyngeal Reflux

Horvath

Fostiropoulos

Burri

et al. 2021

JCM

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“…15 Thus, although many studies are currently under way to nd an objective and noninvasive diagnostic strategy for LPRD, there is still no de nitive diagnostic method. 23 Recently, the diagnostic value of pepsin has emerged as a noninvasive, low-cost salivary pepsin detection method. 8, [19][20][21]24 Pepsin is a speci c biomarker that can detect gastric re ux and saliva, because it is produced only in the stomach.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Matrix Metalloproteinase-7 in Saliva as a Diagnostic Biomarker for Laryngopharyngeal Reflux Disease.

Im¹,

Kim²,

Jung

et al. 2021

Preprint

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Introduction Several diagnostic methods are currently being used to diagnose LPRD (laryngopharyngeal reflux disease), but have the disadvantage of being invasive, subjective, or expensive. Objectives Our purpose in this study was to investigate the correlation between pepsin and MMP-7 (Matrix Metalloproteinase-7) in pharyngeal secretions of subjects according to RSI (Reflux Symptom Index) score to find out the diagnostic value of MMP-7. Method We recruited 173 subjects aged between 19 and 85 years who completed the RSI scale. All samples were taken after waking up, and the amount of the pepsin and MMP-7 in saliva were measured by means of an enzyme activity assay. Results There was a significant increase of pepsin and MMP-7 activity in the study group with an RSI score of 13 or higher. The sensitivity and specificity of MMP-7 for predicting the possibility of an RSI of 13 or more was higher than that of pepsin. When MMP-7 and pepsin were combined, this sensitivity and specificity increased. Conclusion An enzyme assay of MMP-7 in saliva may be a noninvasive and easy technique for diagnosing LPRD.

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“…Cherry first introduced the term LPR in 1968 as a larynx disease associated with reflux or reflux-related laryngeal disease. The current most widely used use of the term LPR was adopted from the American Academy in 2002 Sirin and Öz (2019). There was an increase of 500% in patients attending the otolaryngology department from 1990 to 2001 due to LPR Priston et al (2013).…”

Section: Literature Reviewmentioning

confidence: 99%

“…The laryngeal mucosa is more sensitive to acids than the oesophagus. Oesophagal damage occurs when exposed to acid more than 50 times a day, while exposure to acid three times a week to the larynx can already cause damage to the larynx Sirin and Öz (2019).…”

Section: Literature Reviewmentioning

confidence: 99%

Improvement of the Life Quality for Laryngopharyngeal Reflux Patients After Receiving Proton Pump Inhibitor (Ppi) Therapy at the Ent-Kl Polyclinic of Uki Hospital January 2021 - February 2021

Marlina

Poluan

Zebua

2021

Int. J. Res. Granthaalayah

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(LPR) is a condition in which gastric content to the and reaches larynx and pharynx so that mucous membranes of the larynx, pharynx, and other respiratory organs are inflamed. The symptoms of LPR can affect daily activities, resulting in a decrease in the quality of life (QOL) of the patients. Proton Pump Inhibitor (PPI) is the main therapy for patients with LPR. PPI can improve the symptoms experienced by patients with LPR. The objective of this research is to determine the QOL of patients with LPR after receiving PPI. This research's method is quasi-experimental studies using and post-test design from January 2021 to February 2021, in 18 patients were assessed for QOL scores using RSI. Each patient was administered 30 mg twice daily before meals for 14 days. Two times of observations are done, before therapy and 14 days after therapy. Data analysis using paired sample T-test. The result is that there is a significant improvement in QOL of patients with LPR on RSI scores after 14 days of administration of 30 mg. (p<0,05). It is concluded that PPI significantly improved the QOL of patients with LPR.

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Laryngopharyngeal reflux concept: what is known and what should we focus on?

Cited by 10 publications

References 10 publications

Value of Transnasal Esophagoscopy in the Workup of Laryngo-Pharyngeal Reflux

Value of Transnasal Esophagoscopy in the Workup of Laryngo-Pharyngeal Reflux

Usefulness of Matrix Metalloproteinase-7 in Saliva as a Diagnostic Biomarker for Laryngopharyngeal Reflux Disease.

Improvement of the Life Quality for Laryngopharyngeal Reflux Patients After Receiving Proton Pump Inhibitor (Ppi) Therapy at the Ent-Kl Polyclinic of Uki Hospital January 2021 - February 2021

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