Laryngopharyngeal reflux: diagnosis, treatment and latest research

Falk, Gregory L.; Vivian, Smilee

doi:10.1007/s10353-016-0385-5

Cited by 10 publications

(7 citation statements)

References 151 publications

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“…A similar positive predictive value was observed for Peptest against symptomatic episodes (69%). Currently, there are well over 100 peer-reviewed publications describing the diagnostic potential of pepsin in LPR [7,19,[49][50][51][52][53][54][55][56][57][58]. Many studies have incorporated the rapid simple pepsin spit saliva test into the battery of diagnostic procedures routinely used in ENT clinics such as questionnaires [36] like the RSI [25] and the RFS [26] together with a flexible transnasal laryngoscope.…”

Section: Discussionmentioning

confidence: 99%

A Multicentre Study in UK Voice Clinics Evaluating the Non-invasive Reflux Diagnostic Peptest in LPR Patients

Dettmar

Watson

McGlashan

et al. 2019

SN Compr. Clin. Med.

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Questionnaires and invasive diagnostic tests are established for diagnosing gastro-esophageal reflux disease (GERD) but shown not to be sensitive or specific for diagnosing laryngopharyngeal reflux (LPR) where vast majority of reflux events are weakly acidic or non-acidic. The research question addressed in the current multicentre study was to determine if the measurement of salivary pepsin is a sensitive, specific and reliable diagnostic test for LPR. Five UK voice clinics recruited a total of 1011 patients presenting with symptoms of LPR and a small group of subjects (n = 22) recruited as asymptomatic control group. Twenty-six patients failed to provide demographic information; the total patient group was 985 providing 2927 salivary pepsin samples for analysis. Study participants provided 3 saliva samples, the first on rising with two samples provided post-prandial (60 min) or post-symptom (15 min). The control group provided one sample on rising and two post-prandial providing a total of 66 samples. Pepsin analysis was carried out using Peptest as previously described. High prevalence of pepsin in patient groups (75%) represents a mean pepsin concentration of 131 ng/ml. The greatest prevalence for pepsin was in the post-prandial sample (155 ng/ml) and the lowest in the morning sample (103 ng/ml). The mean pepsin concentration in the control group was 0 ng/ml. Patients across all 5 clinics showed high prevalence of salivary pepsin (ranging from 69 to 86%), and the overall sensitivity was 76.4% and specificity 100%. Pepsin was shown to be an ideal biomarker for detecting airway reflux and LPR.

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Section: Discussionmentioning

confidence: 99%

A Multicentre Study in UK Voice Clinics Evaluating the Non-invasive Reflux Diagnostic Peptest in LPR Patients

Dettmar

Watson

McGlashan

et al. 2019

SN Compr. Clin. Med.

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“…Unfortunately medical therapy uses compounds (antacid drugs; proton pump inhibitors, PPI), which contain various forms of sugars (concentrated sugar, artificial sugar, sweeteners, etc.) [ 1 , 2 ]. This at least may in part explain some of the side effects of PPI therapy, including gas bloat, fullness, diarrhea, and abdominal discomfort.…”

Section: Discussionmentioning

confidence: 99%

Dietary sugar and Barrett’s esophagus

Riegler¹,

Kristo

Asari

et al. 2017

Eur Surg

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SummaryIntroductionBarrett’s esophagus (BE) represents the premalignant morphology of gastroesophageal reflux disease (GERD). Evidence indicates a positive correlation between GERD vs. obesity and increased sugar consumption.MethodsHere we analyzed recently published data (2006–2017) on the role of dietary sugar intake for BE development (main focus year 2017).ResultsRecent investigations found a positive association between obesity, hip waist ratio and dietary sugar intake and Barrett’s esophagus.ConclusionSugar intake positively associates with BE. A low carbohydrate diet should be recommended for persons with BE and GERD.

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“…The scintigraphic technique has been extensively described in previous publications [19][20][21][22][23]. Briefly, patients were fasted for 4 hours prior to the scan.…”

Section: Scintigraphic Methodsmentioning

confidence: 99%

A putative link between pertussis and new onset of gastroesophageal reflux. An observational study.

et al. 2022

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Background: Pertussis is an infectious disease of the respiratory tract with a changing epidemiology. An increasing incidence has been found in the adult population with recurrent infections possibly related to changes in the current vaccine. Is there an association between pertussis infection, refractory cough and atypical gastro-oesophageal reflux (GORD)? Does this magnify and compound respiratory complications?Methods: Observational study which compares post-pertussis (n=103) with non-pertussis patients (n=105) with established GORD. Patients were assessed for laryngopharyngeal reflux and aspiration of refluxate by a novel scintigraphic study.Results: Both groups showed severe GORD in association with high rates of laryngopharyngeal reflux (LPR) and pulmonary aspiration and lung disease. High rates of hiatus hernia and clinical diagnosis of “atypical” asthma showed correlations with pulmonary aspiration.Conclusions: A high level of new onset LPR and lung aspiration has been shown in patients with chronic cough after recent pertussis infection by a novel scintigraphic technique with fused hybrid x-ray computed tomography (SPECT/CT).

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Laryngopharyngeal reflux: diagnosis, treatment and latest research

Cited by 10 publications

References 151 publications

A Multicentre Study in UK Voice Clinics Evaluating the Non-invasive Reflux Diagnostic Peptest in LPR Patients

A Multicentre Study in UK Voice Clinics Evaluating the Non-invasive Reflux Diagnostic Peptest in LPR Patients

Dietary sugar and Barrett’s esophagus

A putative link between pertussis and new onset of gastroesophageal reflux. An observational study.

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