Laryngopharyngeal reflux in chronic obstructive pulmonary disease - a multi-centre study

Sanchez, Julia; Schumann, Desiree M.; Karakioulaki, Meropi; Papakonstantinou, Eleni; Rassouli, Frank; Frasnelli, Matthias; Brutsche, Martin; Tamm, Michael; Stolz, Daiana

doi:10.1186/s12931-020-01473-2

Cited by 9 publications

(5 citation statements)

References 25 publications

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“…Several potential mechanisms may explain the increased risk of COPD associated with GERD. First, GERD reflux can lead to chemical or aspirational pneumonia (Sanchez et al, 2020), which can further promote the occurrence and progression of COPD (Hu et al, 2015). Studies have found that controlling GERD with proton pump inhibitors significantly reduces the risk of exacerbations in COPD (Kang et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

Common gastrointestinal diseases and chronic obstructive pulmonary disease risk: a bidirectional Mendelian randomization analysis

Shen,

Qiu,

Chen

et al. 2023

Front. Genet.

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Background: Observational studies suggest an association between gastrointestinal diseases and chronic obstructive pulmonary disease (COPD), but the causal relationship remains unclear.Methods: We conducted bidirectional Mendelian randomization (MR) analysis using summary data from genome-wide association study (GWAS) to explore the causal relationship between common gastrointestinal diseases and COPD. Gastrointestinal diseases included gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), irritable bowel syndrome (IBS), Crohn’s disease (CD), ulcerative colitis (UC), functional dyspepsia (FD), non-infectious gastroenteritis (NGE), and constipation (CP). Significant MR analysis results were replicated in the COPD validation cohort.Results: Bidirectional MR analysis supported a bidirectional causal relationship between GERD and COPD, and COPD was also found to increase the risk of IBS and CP. Our study also provided evidence for a bidirectional causal relationship between PUD and COPD, although the strength of evidence may be insufficient. Furthermore, we provided evidence that there is no causal association between CD, UC, FD, NGE, and COPD.Conclusion: This study offers some evidence to clarify the causal relationship between common gastrointestinal diseases and COPD. Further research is needed to understand the underlying mechanisms of these associations.

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Section: Discussionmentioning

confidence: 99%

Common gastrointestinal diseases and chronic obstructive pulmonary disease risk: a bidirectional Mendelian randomization analysis

Shen,

Qiu,

Chen

et al. 2023

Front. Genet.

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“…As a result of COPD patients having a common cough, GERD is associated with COPD and is considered a co-morbidity 77 . In fact, GERD has been observed to be a predictor of exacerbations in COPD and implies that a higher prevalence of these bacteria could be used as a potential indicator of COPD exacerbations 77 , 78 .…”

Section: Discussionmentioning

confidence: 99%

Lung microbiome of stable and exacerbated COPD patients in Tshwane, South Africa

Mahomed

Peters

Allam

et al. 2021

Sci Rep

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Chronic obstructive pulmonary disease (COPD) is characterised by the occurrence of exacerbations triggered by infections. The aim of this study was to determine the composition of the lung microbiome and lung virome in patients with COPD in an African setting and to compare their composition between the stable and exacerbated states. Twenty-four adult COPD patients were recruited from three hospitals. Sputum was collected and bacterial DNA was extracted. Targeted metagenomics was performed to determine the microbiome composition. Viral DNA and RNA were extracted from selected samples followed by cDNA conversion. Shotgun metagenomics sequencing was performed on pooled DNA and RNA. The most abundant phyla across all samples were Firmicutes and Proteobacteria. The following genera were most prevalent: Haemophilus and Streptococcus. There were no considerable differences for alpha and beta diversity measures between the disease states. However, a difference in the abundances between disease states was observed for: (i) Serratia (3% lower abundance in exacerbated state), (ii) Granulicatella (2.2% higher abundance in exacerbated state), (iii) Haemophilus (5.7% higher abundance in exacerbated state) and (iv) Veillonella (2.5% higher abundance in exacerbated state). Virome analysis showed a high abundance of the BeAn 58058 virus, a member of the Poxviridae family, in all six samples (90% to 94%). This study is among the first to report lung microbiome composition in COPD patients from Africa. In this small sample set, no differences in alpha or beta diversity between stable and exacerbated disease state was observed, but an unexpectedly high frequency of BeAn 58058 virus was observed. These observations highlight the need for further research of the lung microbiome of COPD patients in African settings.

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“…The more severe the degree of COPD, the more prominent gastrointestinal symptoms. 18,19 The reflux was caused by the incompetence of the lower oesophagal sphincter (LES). Reflux can occur through 3 mechanisms: spontaneous reflux during LES relaxation, backflow of gastric content during the swallowing process, and increase of abdominal pressure.…”

Section: Pathomechanism Of Gerd and Lung Diseasementioning

confidence: 99%

Chronic Lung and Gastrointestinal Diseases: Take a Broader Perspective

Mustika

Effendi

2022

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Chronic lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are often found with gastrointestinal symptoms or even gastrointestinal diseases as one of its comorbid. Vice versa, many cases of gastrointestinal diseases such as gastroesophageal reflux disease (GERD) have developed respiratory dysfunction later. The connection between these two systems has become interesting lately and has led to several studies to prove the association. Several theories have emerged to explain this association. This includes changes in microbiota, the mucosa-related immune system of both systems, side effects of the therapeutic given, and pathomechanism related to gastrointestinal diseases such as GERD. Many studies try to prove the connection between the microbiota in the respiratory and gastrointestinal system, and changing the abundance in one of the systems can affect another. Both of the systems also have a similar mucosal membrane in their lining. Those membranes have an immune defence called Mucosal-Associated Lymphoid Tissue (MALT). Lymphatic and circulatory systems facilitate the migration between two mucosal, and these interconnections influence each other. Although the side effect of the therapeutic agent in respiratory diseases (such as inhaled corticosteroid, beta-2 agonist, or anti-cholinergic) is thought to be one of the causative mechanisms, discontinuation of therapy is the second option. Probiotic supplementation to improve microbiota is still not a strong recommendation for management.

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Laryngopharyngeal reflux in chronic obstructive pulmonary disease - a multi-centre study

Cited by 9 publications

References 25 publications

Common gastrointestinal diseases and chronic obstructive pulmonary disease risk: a bidirectional Mendelian randomization analysis

Common gastrointestinal diseases and chronic obstructive pulmonary disease risk: a bidirectional Mendelian randomization analysis

Lung microbiome of stable and exacerbated COPD patients in Tshwane, South Africa

Chronic Lung and Gastrointestinal Diseases: Take a Broader Perspective

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