The modeling efficiency, matching, and biocompatibility are key factors affecting the surgical success of a personalized thyroid cartilage prosthesis. We performed three-dimensional reconstruction of a thyroid cartilage prosthesis by combining reverse and forward methods, and then completed the prosthesis design with total or partial resection using a parametric modeling method. Direct manufacturing was performed using selective laser melting (SLM) molding equipment and TC4 material. The structure of the completed implant unit was optimized. The results show good modeling effects for the thyroid cartilage prosthesis with either total or partial resection by the parametric modeling method. Good matching performance was achieved, with overlap suspension between the pillars that meets the requirements of SLM manufacturing. Additionally, the use of SLM molding to produce the thyroid cartilage prosthesis resulted in less powder adhesion on the surface and no obvious nodulation between the porous pillars, allowing the direct use of the prothesis after simple post-treatment. Overall, these results should facilitate the direct application of personalized implants.