Laser 904 nm action on bone repair in rats with osteoporosis

Pires-Oliveira, Deise A. A.; Oliveira, Rodrigo Franco de; Amadei, Susana Ungaro; Soares, Cristina Pacheco; Rocha, Rosilene Fernandes da

doi:10.1007/s00198-010-1183-8

Cited by 52 publications

(27 citation statements)

References 25 publications

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“…LLLT also has various effects in bone tissue according to the application parameters, such as the type of laser used, energy density (J/cm 2 ), time and frequency of irradiation, and wavelength, which can contribute effectively to the stimulation of bone cells by increasing the osteoblastic activity at the defect area. 2,14,22 Thus, the biomodulatory effects of laser irradiation seem to be dose dependent. 2 In addition, the method of application can also influence the biostimulatory effect of the laser on bone cells.…”

Section: 18mentioning

confidence: 99%

“…31 Moreover, some authors have demonstrated positive biostimulatory effects of LLLT with longer wavelengths (904-980 nm) on the bone regeneration process. 14,24,32 In this study, a Ga-Al-As diode laser operating at a wavelength of 940 nm was used due to its improved tissue penetration profile. We thought that the low-intensity irradiation from a 940 nm GaAlAs diode laser used in this study would be able to promote bone healing at a deeper level in healthy rats.…”

mentioning

confidence: 99%

“…33 However, many different irradiation times have been used to increase the biostimulatory effect of LLLT on the bone healing pattern in previous studies. 3,4,14 Furthermore, most studies concerning the effects of LLLT on bone healing present a shorter irradiation period, varying from 10 seconds to 30 seconds, which is the most commonly used irradiation method in studies on the effect of LLLT on bone healing. 22,32 In our study, although the different energy densities were achieved by altering the power applied during a constant irradiation time of 10 seconds, LLLT showed no substantial promoting effect on the repair process of bone defects.…”

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confidence: 99%

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The efficacy of low-level 940 nm laser therapy with different energy intensities on bone healing

et al. 2017

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The aim of this study was to evaluate the efficacy of low-level 940 nm laser therapy with energy intensities of 5, 10 and 20 J/cm 2 on bone healing in an animal model. A total of 48 female adult Wistar rats underwent surgery to create bone defects in the right tibias. Low-level laser therapy (LLLT) was applied immediately after surgery and on post-operative days 2, 4, 6, 8, 10 and 12 in three study groups with energy intensities of 5 J/cm 2 , 10 J/cm 2 and 20 J/cm 2 using a 940 nm Gallium-Aluminium-Arsenide (Ga-Al-As) laser, while one control group underwent only the tibia defect surgery. All animals were sacrificed 4 or 8 weeks post-surgery. Fibroblasts, osteoblasts, osteocytes, osteoclasts and newly formed vessels were evaluated by a histological examination. No significant change was observed in the number of osteocytes, osteoblasts, osteoclasts and newly formed vessels at either time period across all laser groups. Although LLLT with the 10 J/cm 2 energy density increased fibroblast activity at the 4th week in comparison with the 5 and 20 J/cm 2 groups, no significant change was observed between the laser groups and the control group. These results indicate that low-level 940 nm laser with different energy intensities may not have marked effects on the bone healing process in both phases of bone formation.

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Section: 18mentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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The efficacy of low-level 940 nm laser therapy with different energy intensities on bone healing

et al. 2017

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“…Pires-Oliveira et al 2010 [16] demonstrated the action of As-GA laser irradiation (904 nm, 50 mJ/cm 2 ) on bone repair in tibia of osteopenic rats using bone densitometry and histomorphometric analyses. The authors found this irradiation model accelerated the repair process in osteopenic fractures, especially in the initial phase of bone regeneration.…”

Section: Open Accessmentioning

confidence: 99%

The recover from the excision in head and neck of femoral after therapy with low level laser

Pacheco‐Soares

Gusmao²,

Ferreira³

et al. 2012

JBiSE

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Degenerative articulate diseases, resulting from dysplasia and aseptic necrosis of the femoral head and neck, chronic dislocation of the femur and osteoarthrosis, are often treated surgically by an excision in the femoral head and neck. This procedure entails the formation of a false fibrous articulation, providing pain relief. The action of low level laser therapy (LLLT) has been described in orthopedic applications, to repair both bone and articular tissue. LLLT has demonstrated favorable results in vitro and in vivo in stimulating bone repair. A diode laser, 650 nm, with a potency of 30 mW, was used trans-surgically to irradiate. A diode laser (780 nm and the potency of 40 mW) was used on the skin for post-surgery applications. For the experiment, 10 clinically normal New Zealander rabbits underwent surgery and were then divided into two groups, one submitted to irradiation and the other kept for sham. Fifteen days after the surgery, samples of the newly formed tissue were collected from both groups, for macroscopic evaluation of the fibrous pseudo-articulation forming process on the irradiated and sham groups. The macroscopic and microscopic appearance of the samples, suggest that the utilization of the LLLT in the formation of fibrous pseudo-articulation was effective in accelerating the cicatrization process and in improving the quality of the formed tissue.

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“…This process results in beneficial therapeutic outcomes including but not limited to the alleviation of pain or inflammation, immunomodulation, and promotion of wound healing and tissue regeneration.^ [1]. PBM therapy was found to have multiple clinical benefits, which includes reducing pain [2][3][4][5][6][7], improving wound healing [8][9][10][11], accelerating bone healing [12][13][14][15][16][17], promoting osteointegration [18], facilitating orthodontic tooth movement [19][20][21][22][23][24][25][26], stimulating bone formation [27][28][29][30][31], and improving periodontal tissue repair and decreasing inflammation and root resorption [23,26,32]. The light sources were laser or a light-emitting diode (LED).…”

Section: Introductionmentioning

confidence: 99%

Light transmittance of the periodontium

et al. 2017

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Objective Photobiomodulation (PBM) therapy stimulates cells and regulates their activities. However, the actual accumulated dose that the cells receive is still unknown because the transmittances of the light on various tissues are not available. The objective of this study is to determine the light transmittances of the oral tissues. Methods Tissue samples of gum, cortical bone, and trabecular bone were prepared from ten Yucatan pigs' mandibles. Both the transmittance and the attenuation coefficient in the Beer-Lambert law were used to characterize the materials' light transmittance behavior. A higher attenuation coefficient indicates lower transmittance. The samples were tested with the light within the wavelength ranging from 420 to 1050 nm. The light intensity measured with and without the samples was used to calculate the transmittance. Results The result showed that the Beer-Lambert law can be used to estimate the transmittance if the light surface loss is eliminated. Among the three tissues, the gum has the highest attenuation coefficient and the trabecular bone has the lowest. The attenuation coefficient is higher at lower wavelengths for all three tissues, and is lower and keeps plateaued at the wavelength from 700 to 1050 nm. The surface loss rate of gum is higher at lower wavelengths. The light intensity within the tested range does not affect the transmittance.

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Laser 904 nm action on bone repair in rats with osteoporosis

Abstract: Low-level 904-nm laser (50 mJ/cm(2)) accelerated the repair process of osteopenic fractures, especially in the initial phase of bone regeneration.

Cited by 52 publications

References 25 publications

The efficacy of low-level 940 nm laser therapy with different energy intensities on bone healing

The efficacy of low-level 940 nm laser therapy with different energy intensities on bone healing

The recover from the excision in head and neck of femoral after therapy with low level laser

Light transmittance of the periodontium

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