Laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS)–based strategies applied for the analysis of metal-binding protein in biological samples: an update on recent advances

Atomic spectrometry update: review of advances in atomic spectrometry and related techniques

“…The findings indicated that selection of the appropriate laser fluence, just above the ablation threshold, and beam size, depending on the interface of LA and ICP-MS, were critical for reliable quantification and should be properly adjusted to avoid excessive Poisson and flicker noise, achieve maximum sensitivity, and prevent the formation of double peaks in single pulses. Recent advances in the application of LA-ICP-MS for the analysis of metal-binding proteins were discussed by Chen et al 64 The focus was on the identification of metal-binding proteins via the determination of endogenous metals. The main strategies, including in situ analysis of biospecimens and ex situ analysis with gel electrophoresis were reviewed.…”

Mass spectrometry-based techniques for single-cell analysis

“…The whole cell sample is progressively laser ablated before being introduced into the mass spectrometer, and this special sampling mode provides high spatial resolution and flexibility for the sample, greatly improving the detection sensitivity. 115–119 Some representative studies are described in subsequent paragraphs.…”

Trace Elements Open a New Direction for the Diagnosis of Atherosclerosis

“…The keratin outer layer of hair forms a barrier with the environment to prevent the escape of accumulated substances (ions). Hair analysis has become a popular source of information in the therapeutic, nutritional, toxicological, and forensic fields recently due to advancements in research techniques [ 68 , 69 ]. Standard analytical procedures for determining the concentration of trace elements in blood and urine may not accurately reflect the current availability of biological elements in organisms.…”