Laser analyses of mixture formation and the influence of solute on particle precipitation in the SAS process

Supercritical Antisolvent Particle Precipitation: In Situ Optical Investigations

“…With respect to spontaneous Raman scattering, the signal intensity was both directly proportional to the number density of solvent or antisolvent molecules and species selective. A detailed explanation regarding the Raman imaging setup and some fundamentals of Raman scattering are provided elsewhere [10,11]. Fig.…”

Optische in‐situ‐Untersuchungen der Partikelbildung im überkritischen Antisolvent‐Prozess

“…Eine genaue Beschreibung des Raman-Versuchsaufbaus sowie der theoretischen Grundlagen zum Messverfahren ist in der Literatur [10,11] Diese Messmethode wurde ausgewählt, da sie sich zur quantitativen Charakterisierung des Mischungsverhaltens eignet.…”

Influence of introduction devices on crystallisation kinetic parameters in a supercritical antisolvent process

“…Carretier et al [19] have considered an approach based on micro mixing characterisation. Other works also deal with the modelling of an organic solvent jet hydrodynamics in SCO 2 , the approach being by dimensionless numbers [20][21][22] or by a complete modelling [23,24]. Some authors have also added the crystallisation step, using global nucleation and growth laws [25].…”