Laser and photodynamic therapy of esophageal cancer

Overholt, Bergein F.

doi:10.1002/ssu.2980080404

Cited by 14 publications

(2 citation statements)

References 58 publications

(65 reference statements)

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“…43 Antegrade treatment can be used if it is not possible to pass the endoscope or guidewire, but carries a higher risk of perforation as the view is restricted by thermally induced oedema. 44…”

Section: Lasermentioning

confidence: 99%

A pragmatic randomised controlled trial of the cost-effectiveness of palliative therapies for patients with inoperable oesophageal cancer

Shenfine

McNamee²,

Steen³

et al. 2005

Health Technol Assess

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It was suggested that rigid tubes and 24-mm SEMS should no longer be recommended and bipolar electrocoagulation and ethanol tumour necrosis should not be used for primary palliation. The choice in palliation would between non-stent and 18-mm SEMS treatments, with non-stent therapies being made more available and accessible to reduce delay. A multidisciplinary team approach to palliation is also suggested. A randomised controlled clinical trial of 18-mm SEMS versus non-stent therapies with survival and quality of life end-points would be helpful, as would an audit of palliative patient admissions to determine the reasons and need for inpatient hospital care, with a view to implementing cycle-associated change to reduce inpatient stay. A study of delays in palliative radiotherapy treatment is also suggested, with a view to implementing cycle-associated change to reduce waiting time.

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Section: Lasermentioning

confidence: 99%

A pragmatic randomised controlled trial of the cost-effectiveness of palliative therapies for patients with inoperable oesophageal cancer

Shenfine

McNamee²,

Steen³

et al. 2005

Health Technol Assess

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“…The laser generates a monochromatic beam, which activates the photosensitive compound and generates cytotoxic singlet oxygen radicals resulting in rapid vascular stasis, hemorrhage, and an acute inflammatory reaction, followed by direct and anoxiainduced tumor cell death. Only Porfimer sodium is available in the United States at this time (80).…”

Section: Pdt Techniquementioning

confidence: 99%

Endoscopic Therapy for Advanced Esophageal Cancer

Canto

Endoscopic Oncology

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BACKGROUNDEsophageal cancer is currently the ninth leading cause of cancer death in the United States, and since the 1970s, the incidence of esophageal adenocarcinoma has been rising at an alarming rate (1). The National Cancer Institutes estimates 14,250 new cases of esophageal cancer and 13,300 deaths owing to esophageal cancer in 2004. The estimated 5-yr mortality rate remains at 5-10% (1).Unfortunately, the majority of patients present with advanced disease that is not curative by surgery (2). Palliative surgery is associated with a relatively high morbidity (20-60%) and mortality (10-33%), and approximately one-third of these patients will develop anastomotic strictures or local tumor recurrence necessitating further intervention (3). Because the median survival of such patients is less than 6 mo, palliative surgery has been replaced by nonsurgical techniques, primarily chemoradiation, brachytherapy, and/or endoscopic therapy (4). This chapter summarizes the goals, safety and efficacy, and techniques for endoscopic palliation of advanced esophageal cancer, focusing primarily on techniques for treatment of malignant dysphagia but also including treatment options for esophageal fistulas and bleeding tumors. TREATMENT OF DYSPHAGIA GOALS OF PALLIATIVE ENDOSCOPIC THERAPY FOR DYSPHAGIAMalignant dysphagia is defined as difficulty swallowing owing to malignancy and usually results from a partially or completely occluded esophageal lumen. It might present as intraluminal disease, extraluminal compression, tumor encroachment on esophageal innervation, or a combination of From: Endoscopic Oncology: Gastrointestinal Endoscopy and Cancer Management.

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