2020
DOI: 10.1111/jocd.13817
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Laser‐assisted delivery of tranexamic acid for melasma: Pilot study using a novel 1927 nm fractional thulium fiber laser

Abstract: Melasma is a common skin condition that is characterized by a chronic and relapsing course. It typically manifests as gray-to-brown patches on sun-exposed areas of the face and neck, which disproportionately affects those of Asian, African, and Hispanic descent. Melasma has been associated with pregnancy, changes in uterine or ovarian hormones, oral contraceptives, and excessive sun exposure. 1

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Cited by 23 publications
(24 citation statements)
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“…This phenomenon has led to their use in laser-assisted drug delivery, including tranexamic acid for melasma. [33][34][35] The presence of channels and their duration seem to be dependent on the amount of tissue coagulation surrounding the channels that are created by the devices. The stiffer coagulated tissue may act as a rigid scaffold to structurally support the channels and hold them open.…”
Section: Discussionmentioning
confidence: 99%
“…This phenomenon has led to their use in laser-assisted drug delivery, including tranexamic acid for melasma. [33][34][35] The presence of channels and their duration seem to be dependent on the amount of tissue coagulation surrounding the channels that are created by the devices. The stiffer coagulated tissue may act as a rigid scaffold to structurally support the channels and hold them open.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, given the absorption spectrum of melanin (250-1200 nm), visible and near-infrared lasers can be used successfully to target excess melanin in the skin in the case of postinflammatory hyperpigmentation [85]. The Q-switched Nd-YAG laser, the fractional thulium laser (via tranexamic acid) and the picosecond alexandrite laser are the most used in the treatment of hyperpigmentation of the skin [86,87].…”
Section: Pt For Viral Stismentioning
confidence: 99%
“…Due to the unique depths, diameters, and transient nature of the channels, this laser can also effectively be used for topical drug delivery. 2 When combining multiple treatments in a single patient visit, it is important to first consider the safety profile of each individual treatment modality. Typical adverse events from BoNT-A include edema, bruising, injection site pain, headache, blepharoptosis, eyebrow ptosis, and eye sensory disorders, such as sensation of heavy eyelids.…”
Section: O S M E T I C C O M M E N T a R Ymentioning
confidence: 99%