Laser-Assisted Drug Delivery

Alegre-Sánchez, A.; Jiménez-Gómez, N.; Boixeda, P.

doi:10.1016/j.adengl.2018.10.012

Cited by 29 publications

(36 citation statements)

References 62 publications

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“…Ablative fractional laser induces a controlled damage by generating cutaneous microcolumns 11,12 . In our study, the healing of the microcolumns caused by the laser treatment was faster on the SCA‐treated side.…”

Section: Discussionsupporting

confidence: 47%

Early and maintained application of the secretion of Cryptomphalus aspersa (SCA) 40% improves cutaneous healing after ablative fractional laser in skin aging

Fernández-González

Vitale²,

Truchuelo

2020

J of Cosmetic Dermatology

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Background Ablative fractional laser generates a regulated skin damage, which secondarily improves skin aging. Aims The main objective of the present study was to figure out if the adverse effects induced by laser and the skin recovery could improve with the application of a cosmetic product based on the secretion of Cryptomphalus aspersa (SCA). Patients/Methods A prospective double‐blind controlled study with vehicle in 10 patients with skin aging. The patients received one session of fractional ablative CO2 laser, and the formulation with SCA 40% was applied immediately and maintained throughout the 21‐day duration of the study. The active treatment (SCA) was applied to one hemifacial area and vehicle to the other, and the patient acting was her own control. Clinical evaluations, dermoscopy, photography, and other parameters like cutaneous hydration, elasticity, and wrinkles were evaluated. In addition, the severity of the adverse effects was evaluated. Results Significant greater decrease in the density of microcolumns produced by laser was detected on the active‐treated side, indicating greater and faster postprocedure recovery compared to the vehicle‐treated side. In addition, side effects were reduced and some antiaging effects were more apparent on the side treated with SCA 40%. Conclusion SCA 40% applied immediately after ablative laser, and during the next days, it can accelerate laser‐induced damage regeneration. In addition, SCA improves the cosmetic outcome after laser application.

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Section: Discussionsupporting

confidence: 47%

Early and maintained application of the secretion of Cryptomphalus aspersa (SCA) 40% improves cutaneous healing after ablative fractional laser in skin aging

Fernández-González

Vitale²,

Truchuelo

2020

J of Cosmetic Dermatology

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“…The post-procedure images were obtained on the 93th day. The prominent temporal superficial veins became less visible after the treatment was recently confirmed as the optimal interval for LADD [15]. Nonetheless, any residual disruption of cutaneous layers can still be observed 3 weeks after LSR [4,10,11].…”

Section: Discussionmentioning

confidence: 88%

“…Although devices such as microneedling may be less expensive as skin physical penetration enhancers, variables such as the different assembly of needles composing the devices available in the market and the operator-dependent employment of strength during microneedling application may cause different depths of penetration. Finally, the high local temperature generated by the laser generates accentuated molecular motion and consequent cutaneous permeation of any topically applied medication toward deeper layers [13][14][15][16][17]. This tissular heat explains the increased efficiency in drug absorption using AFXLs over other physical penetration enhancers [16,17].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial

Machado

Frame²,

Zhang³

et al. 2020

Aesth Plast Surg

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Background Despite promising results, laser-assisted drug delivery (LADD) is not yet considered as standard therapies and published data rely mainly on laboratory tests, animal experiments or cadaver skin. Objectives This double-blind, prospective, randomized clinical trial investigates the impact in topical application of vitamin C and a cosmeceutical containing growth factors (GFs) on periorbital wrinkles primarily treated with laser skin resurfacing. Material and Methods In total, 149 female patients with periorbital wrinkles were consented and randomized into two study groups, R-C (receiving vitamin C only) and R-CGF (receiving vitamin C and a cosmeceutical containing growth factors). The statistical analysis evaluated the efficacy of each treatment regimen using software readouts provided by a three-dimensional stereophotogrammetry system prior to treatment and three months after the procedure. Results were compared to confirm if there was a significant change in the skin roughness and the average depth of the wrinkles between the two groups after treatment. Results There was a significant reduction in both skin roughness and average depth of the wrinkles in the group treated with vitamin C and growth factors (p <0.01) than those treated with LADD followed by topical application of vitamin C alone. There were no cutaneous reactions or adverse systemic reactions observed in this study related to LADD with vitamin C and GFs. Conclusion Controlled laser application might have a great potential to facilitate the absorption of exogenous macromolecules by the skin. Periorbital wrinkles were reduced in both groups, but LADD using vitamin C and GFs provided significantly better results. Level of Evidence II This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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“…The rise in antibiotic level had highly significant in all groups for 1h and 2h furthermore then began to lessen through time until reach clearance approximately. Medications for example procaine, certain antibiotics, can be improved their efficiency through laser assist by intensifying their receptor sites [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Improvement of antibiotics absorption and regulation of tissue oxygenation through blood laser irradiation

Al-Timimi

2021

Heliyon

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A point of this work is to estimate the impact of laser blood irradiation controlled intravenously at the level of an antibiotic. Hundred and twenty grown-up female adult rabbits were utilized in this investigation. They were separated into two equivalent groups relying upon the method for managing of the antibiotic. First group injected with10 mg/kg b. w of Moxifloxacin antibiotic while second group was given the Moxifloxacin but in a type of a tablet, containing 10 mg/kg.b.w orally. Following, each group was partitioned into four equivalent subgroups; control and treated with laser therapy at different time. Gallium-Arsenide (GaAs) laser device, utilized for treatment, in wavelength 904 nm, power of 5mW, its include a connector by optical fiber with fine cannula fixed at its end. Rabbits of laser subgroup; were treated by presenting needle of cannula into ear-marginal vein for 10, 20 and 30min. Blood samples have been collected from both groups after 1, 2, 3, 4, 5 and 6 h intervals after treatment and had transmitted for analysis via a high-pressure liquid chromatography to determine level of Moxifloxacin in blood. The after-effects' revealed a regular increment in Moxifloxacin level (ng/ml) in two groups until 3 h followed with a rapid decline until the end of the experiment. Blood Irradiation through low-level laser enhances the concentration of Moxifloxacin in the serum whatsoever; was the rout of its performance, besides the irradiation help within quickened clearance of blood beginning the drug.

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Laser-Assisted Drug Delivery

Cited by 29 publications

References 62 publications

Early and maintained application of the secretion of Cryptomphalus aspersa (SCA) 40% improves cutaneous healing after ablative fractional laser in skin aging

Early and maintained application of the secretion of Cryptomphalus aspersa (SCA) 40% improves cutaneous healing after ablative fractional laser in skin aging

Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial

Improvement of antibiotics absorption and regulation of tissue oxygenation through blood laser irradiation

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