Laser-assisted photodynamic therapy in proliferative verrucous oral leukoplakia

Yan, Yujie; Li, Zhenglei; Tian, Xin; Zeng, Xin; Chen, Qianming; Wang, Jiongke

doi:10.1016/j.pdpdt.2022.103002

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…We discovered 17 individuals relapsed among the 23 patients receiving treatment, which is roughly consistent with a meta-analysis indicating a recurrence rate of 67.2% [ 34 ]. Previous case studies have demonstrated that the use of topical photodynamic therapy with diode laser drilling pre-treatment can prevent the recurrence of lesions [ 35 , 36 ]. However, the relationship between treatment methods and PVL malignancy transformation remains poorly researched [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical, histopathological characteristics and malignant transformation of proliferative verrucous leukoplakia with 36 patients: a retrospective longitudinal study

Zhang,

Lan,

Wei

et al. 2024

BMC Oral Health

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Background Proliferative verrucous leukoplakia (PVL), distinguished by its malignant transformation rate of 43.87% to 65.8%, stands as the oral potentially malignant disorder with the highest propensity for malignancy. PVL is marked by distinctive heterogeneity regarding the clinical or histopathological characteristics as well as prognostic factors pertinent to this condition. The purpose of this study is to compile and assess the clinicopathological features, malignant transformation, and associated risk factors in patients diagnosed with PVL. Methods This study is a hospital-based retrospective longitudinal study of 36 patients diagnosed with PVL from 2013 to 2023. We conducted complete clinical and histopathological evaluations of the patients. Results The cohort comprised 16 males and 20 females, yielding a male-to-female ratio of 1:1.25. The follow-up period ranged from 8 to 125 months, with an average of 47.50 months. The most common clinical type of lesion was the verrucous form (58.33%), and the gingiva was the most common site (44.44%). Each patient had between 2 to 7 lesions, averaging 3.36 per patient. During the follow-up period, twelve patients (33.3%) developed oral cancer, with an average time to malignant transformation of 35.75 months. Kaplan–Meier survival analysis indicated that patients with complaints of pain, roughness, or a rough sensation, with diabetes, and the presence of cytologic atypia histologically showed a higher risk of malignant transformation (p < 0.05). In this study, the rate of malignant transformation in the treatment group (5/23) was lower than that in the untreated group (7/13), however, no statistically significant difference (p = 0.05). Conclusion The main complaints of pain, roughness, or foreign body sensation, coupled with cytologic atypia histologically are indicative of an increased risk of malignant transformation in PVL. Further research is needed to elucidate the influence of these clinicopathological parameters on the malignant progression of PVL.

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Section: Discussionmentioning

confidence: 99%

Clinical, histopathological characteristics and malignant transformation of proliferative verrucous leukoplakia with 36 patients: a retrospective longitudinal study

Zhang,

Lan,

Wei

et al. 2024

BMC Oral Health

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“…The interaction between the light source and the photosensitizer is activated in the presence of oxygen, generating reactive oxygen species (ROS). Intracellular cytotoxic ROS then cause oxidative damage to precancerous and malignant cells [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of photodynamic therapy for oral leukoplakia: a retrospective study of 50 patients

Wang,

Tang,

Wang

et al. 2024

BMC Oral Health

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Background Topical photodynamic therapy (PDT) has demonstrated encouraging results in the treatment of oral leukoplakia (OLK). However, data on the clinical efficacy of PDT in Chinese patients with OLK are still limited. Methods Fifty patients diagnosed with OLK were enrolled, including patients with various dysplastic tissues. All patients received topical PDT with 5-aminolevulinic acid (5-ALA) as a photosensitizer. Clinical efficacy was evaluated 4 weeks after treatment. Follow-up was performed every 3 months during the first year and every 6 months during the second year. Results The overall response rate was 68% (34/50): 12% (n = 6) complete and 56% (n = 28) partial responses. Aneuploidy was reduced in the patients with dysplastic lesions. Oral pain and local ulcers developed in 52% of the patients (n = 26). Patients with a long history of OLK including hyperplasia and dysplastic lesions, as well as those with non-homogenous lesions, were more likely to develop pain and ulcer. During follow-up, the recurrence rate of hyperplasia and dysplastic lesions was 32% (n = 16) and the malignant transformation rate of dysplastic lesions was 4% (n = 2). Lesions on the buccal mucosa were associated with recurrence (P = 0.044; OR: 0.108, 95% CI: 0.013–0.915). Conclusion Topical 5-ALA-mediated PDT is an effective treatment for OLK, particularly for homogenous leukoplakia, with few side effects. The buccal mucosa may be a protective factor that can reduce recurrence.

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A Bibliometric and Visualised Analysis of Proliferative Verrucous Leucoplakia From 2003 to 2023

Zhu,

Ou,

Yang

et al. 2024

International Dental Journal

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Laser-assisted photodynamic therapy in proliferative verrucous oral leukoplakia

Cited by 3 publications

References 7 publications

Clinical, histopathological characteristics and malignant transformation of proliferative verrucous leukoplakia with 36 patients: a retrospective longitudinal study

Clinical, histopathological characteristics and malignant transformation of proliferative verrucous leukoplakia with 36 patients: a retrospective longitudinal study

Clinical evaluation of photodynamic therapy for oral leukoplakia: a retrospective study of 50 patients

A Bibliometric and Visualised Analysis of Proliferative Verrucous Leucoplakia From 2003 to 2023

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