2015
DOI: 10.18053/jctres.201501.001
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Laser-assisted vascular welding: optimization of acute and post-hydration welding strength

Abstract: Background: Liquid solder laser-assisted vascular welding using biocompatible polymeric scaffolds (ssLAVW) is a novel technique for vascular anastomoses. Although ssLAVW has pronounced advantages over conventional suturing, drawbacks include low welding strength and extensive thermal damage. Aim: To determine optimal ssLAVW parameters for maximum welding strength and minimal thermal damage. Methods: Substudy 1 compared breaking strength (BS) of aortic strips welded with electrospun poly( -caprolactone) (PCL) o… Show more

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“…ssLAVW produces greater welding strengths than sLAVW due to a greatly enhanced cohesive strength [15][16][17][18][19][20][21][22][23]. To date, poly(lactic-co-glycolic acid) (PLGA) and poly( -caprolactone) (PCL) have been the two most commonly used (co) polymers in ssLAVW [15][16][17][18][19][20][21][22][23]. PCL is typically favored over PLGA insofar as PCL use is not associated with the formation of acidic byproducts following LAVW [19][20][21][22][23].…”
Section: Introductionmentioning
confidence: 99%
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“…ssLAVW produces greater welding strengths than sLAVW due to a greatly enhanced cohesive strength [15][16][17][18][19][20][21][22][23]. To date, poly(lactic-co-glycolic acid) (PLGA) and poly( -caprolactone) (PCL) have been the two most commonly used (co) polymers in ssLAVW [15][16][17][18][19][20][21][22][23]. PCL is typically favored over PLGA insofar as PCL use is not associated with the formation of acidic byproducts following LAVW [19][20][21][22][23].…”
Section: Introductionmentioning
confidence: 99%
“…To date, poly(lactic-co-glycolic acid) (PLGA) and poly( -caprolactone) (PCL) have been the two most commonly used (co) polymers in ssLAVW [15][16][17][18][19][20][21][22][23]. PCL is typically favored over PLGA insofar as PCL use is not associated with the formation of acidic byproducts following LAVW [19][20][21][22][23]. However, the low melting point of PCL (60°C, i.e., the approximate temperature at which collagen and albumin start to denature) causes the scaffold to shrink, inducing a diametrical mismatch between the upper and lower part of the vessel that, in the clinical setting, may lead to aneurysm formation [20,24].…”
Section: Introductionmentioning
confidence: 99%