Laser‐Based Spectroscopic Methods in Tissue Characterization

Svanberg, Katarina; Klinteberg, Claes af; Nilsson, Andréas; Wang, I; Andersson‐Engels, Stefan; Svanberg, Sune

doi:10.1111/j.1749-6632.1998.tb08193.x

Cited by 23 publications

(18 citation statements)

References 8 publications

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“…Due to the poor results (see below) it was therefore decided to discontinue the study after the interim analysis. A total of 35 analysis. Fifteen had a significant hiatal hernia (>3 cm in diameter), five had a small hiatal hernia (<3 cm in diameter), and 15 patients did not have a hiatal hernia.…”

Section: Patientsmentioning

confidence: 99%

Biopsy surveillance is still necessary in patients with Barrett's oesophagus despite new endoscopic imaging techniques

Egger

2003

Gut

124

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Background and aims: Endoscopic surveillance including stepwise four quadrant biopsies (4QB) is still regarded as the standard approach in patients with Barrett's oesophagus (BO). Several methods such as dye staining with methylene blue (MB) and tissue autofluorescence (AF) have been advocated to reduce the number of biopsies. We assessed their sensitivity and specificity compared with the standard approach-that is, endoscopy with 4QB-in the surveillance of a mixed BO population. Patients and methods: Thirty five consecutive BO patients (mean age 64.9 years; 30 men, five women) were included in the study. AF endoscopy was followed by high resolution video endoscopy (VE) plus tissue staining with 0.5% MB. Biopsies were taken from any suspicious area found on any of the above tests, in addition to 4QB every 2 cm. The results were classified as either positive or negative for the various tests used. Histopathological results were used as the reference standard. Results: In the 35 study patients, a total of 345 biopsies showed low grade dysplasia (LGD) in 88 biopsies, high grade dysplasia (HGD) in 19 biopsies, and carcinoma in 12 biopsies. The sensitivity and specificity rates for AF and MB for the diagnosis of cancer or dysplasia versus BO mucosa without dysplasia were 21%/91% and 37%/91%, respectively. 4QB revealed five cancer/HGD areas and 76 LGD areas not detected by AF, MB, or VE. The additional yield of MB and AF over VE with 4QB concerned only one HGD area (in the vicinity of a cancer) and seven LGD areas. Conclusions: Due to their low sensitivity, AF and MB are not suitable techniques for reducing the high numbers of routine biopsies needed for finding additional foci of HGD or cancer. Careful endoscopic observation and stepwise four quadrant biopsy therefore still represent the gold standard for surveillance of Barrett's oesophagus.

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Section: Patientsmentioning

confidence: 99%

Biopsy surveillance is still necessary in patients with Barrett's oesophagus despite new endoscopic imaging techniques

Egger

2003

Gut

124

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“…Sabe-se que a água está envolvida em todos os eventos biológicos, inclusive no processo de cicatrização. A habilidade de reparo a injúrias foi avaliada, baseando-se no registro da fluorescência nativa da pele (Stamatas et al, 2006 (Andersson et al, 1987;Kennedy et al, 1996;Svanberg et al, 1998;Zellweger et al, 2001). ALA é um composto endógeno que participa da síntese do heme e, em excesso, leva ao acúmulo intracelular da protoporfirina IX (AngellPetersen et al, 2007) que pode ser ativada com luz visível (Juzenas et al, 2002b).…”

Section: Cicatrização Da Peleunclassified

“…Os ésteres derivados do ALA são relatados como mais lipofílicos e com maior poder de penetração no tecido cutâneo Estudos diversos compararam, ainda, a fluorescência da pele normal com a fluorescência apresentada em lesões pré-malignas e malignas da pele, como ceratose actínica e carcinoma baso-celular, respectivamente (Svanberg et al, 1998;Wennberg et al, 2000;Peng et al, 2001;Sharfaei et al, 2002;Juzenas et al, 2002a Verticais Uniformes Randômicos (VUR). O primeiro tipo de corte, só pode ser aplicado a materiais isotrópicos, ou seja, com distribuição homogênea de estruturas, como uma esfera, por exemplo.…”

Section: Cicatrização Da Peleunclassified

“…(Svanberg et al, 1998;Wennberg et al, 2000;Peng et al, 2001;Sharfaei et al, 2002;Juzenas et al, 2002b A última hipótese parece mais plausível.…”

Section: Espectroscopia De Fluorescênciaunclassified

“…Essa hipótese, relacionando a IF ao período de proliferação e epitelização da cicatrização, é apoiada pela observação de diversos estudos que correlacionam a intensidade de fluorescência ao espessamento epidérmico, como nas lesões de psoríase (Smits et.al., 2005) e em lesões pré-malignas e malignas, como carcinoma de células escamosas (Kleinnpening et.al., 2006;Stenquist et al, 2006), ou em outras condições clínicas (Svanberg et al, 1998;Wennberg et al, 2000;Peng et al, 2001;Sharfaei et al, 2002;Juzenas et al, 2002b).…”

Section: Espectroscopia De Fluorescênciaunclassified

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Fluorescent Molecular Imaging and Dosimetry Tools in Photodynamic Therapy

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Measurement of fluorescence and phosphorescence in vivo is readily used to quantify the concentration of specific species that are relevant to photodynamic therapy. However, the tools to make the data quantitatively accurate vary considerably between different applications. Sampling of the signal can be done with point samples, such as specialized fiber probes or from bulk regions with either imaging or sampling, and then in broad region image-guided manner. Each of these methods is described below, the application to imaging photosensitizer uptake is discussed, and developing methods to image molecular responses to therapy are outlined.

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Laser‐Based Spectroscopic Methods in Tissue Characterization

Cited by 23 publications

References 8 publications

Biopsy surveillance is still necessary in patients with Barrett's oesophagus despite new endoscopic imaging techniques

Biopsy surveillance is still necessary in patients with Barrett's oesophagus despite new endoscopic imaging techniques

Avaliação da cicatrização cutânea: fluorescência e estereologia

Fluorescent Molecular Imaging and Dosimetry Tools in Photodynamic Therapy

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