Laser Correlation Spectroscopy of Macromolecular Complexes in Blood Serum Is an Efficient Method for Detecting Insulin Overdose and Correction of the Insulin Therapy for Diabetes Mellitus in Children

Rumyantseva, E. I.; Ковалев, И. Е.; Kovaleva, O. I.; Karganov, M. Yu.

doi:10.1007/s10628-005-0073-z

Cited by 3 publications

(1 citation statement)

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“…This mathematical apparatus for the solution of inverse spectral problem is similar to that used successfully in modern X-ray and NMR tomography. The LCS method was previously applied for evaluation of the disease severity and efficiency of treatment in patients with asthma [12], diabetes mellitus [13,14], myasthenia [15], and other pathologies.…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of the Informative Value of Radioimmunoassay and Laser Correlation Spectroscopy in Myasthenia Gravis

et al. 2014

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The objective of this study was to compare informative value of traditional approach (anti-AChR antibody radioimmunoassay) and evaluation of metabolic shifts by laser correlation spectroscopy in myasthenia gravis. The method based on changes in spectral characteristics of laser radiation caused by scattering in a disperse system yields a histogram reflecting particle contribution into light scatter as a function of particle radius in nanometers. The spectrum of anti-AChR-positive serum is characterized by appreciably increased contribution of particles with a radius 4.6–6.2 nm. Binding of serum components with solubilized AChR confirms that this peak is determined by elevated concentration of antibodies to this receptor. The search for the relationship between the disease severity and the distribution pattern of subfraction serum components revealed three informative zones: 6–15, 27–67, and 127–223 nm. In patients without disturbances of vital functions, the contribution of the first zone particles into light scatter increases and that of the third zone particles decreases. Considerable differences attaining the level of statistical significance in zones 4–6 and 20 nm were revealed in the spectra of serum from patients with myasthenia gravis of the same severity with and without thymoma. This opens prospects for dynamic monitoring of the efficiency of therapy.

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Section: Introductionmentioning

confidence: 99%

Comparative Analysis of the Informative Value of Radioimmunoassay and Laser Correlation Spectroscopy in Myasthenia Gravis

et al. 2014

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Laser correlation spectroscopy in the diagnosis of tumor diseases of the female reproductive system (preliminary results)

Korneeva

Sekerskaya

Zhordaniya

et al. 2017

J. Phys.: Conf. Ser.

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A comparative analysis of the informative value of anti-AChR-antibody radioimmunoassay and laser correlation spectroscopy in myasthenia gravis

Алчинова

Yakovenko

Сиднев

et al. 2017

Z. nevrol. psikhiatr. im. S.S. Korsakova

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In patients without disturbances of vital functions, the contribution of the first zone particles into light scatter increases and that of the third zone particles decreases. Considerable differences attaining the level of statistical significance in zones 6 and 20 nm were revealed in the spectra of serum from patients with myasthenia gravis of the same severity with and without thymoma. This opens prospects for dynamic monitoring of the efficiency of therapy.

show abstract

Laser Correlation Spectroscopy of Macromolecular Complexes in Blood Serum Is an Efficient Method for Detecting Insulin Overdose and Correction of the Insulin Therapy for Diabetes Mellitus in Children

Cited by 3 publications

References 1 publication

Comparative Analysis of the Informative Value of Radioimmunoassay and Laser Correlation Spectroscopy in Myasthenia Gravis

Comparative Analysis of the Informative Value of Radioimmunoassay and Laser Correlation Spectroscopy in Myasthenia Gravis

Laser correlation spectroscopy in the diagnosis of tumor diseases of the female reproductive system (preliminary results)

A comparative analysis of the informative value of anti-AChR-antibody radioimmunoassay and laser correlation spectroscopy in myasthenia gravis

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