Laser Decontamination and LED Photobiomodulation Promote Bone Regeneration and Wound Healing by Secondary Intention, in Alveolar Ridge Preservation—Clinical and Radiographic Evaluation: A Pilot Experience

Caccianiga, Gianluigi; Rey, Gérard; Baldoni, M; Caccianiga, Paolo; Porcaro, G; Baldoni, Alessandro; Ceraulo, Saverio

doi:10.1089/photob.2021.0062

Cited by 10 publications

(10 citation statements)

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“…The use of laser was the most studied in the literature, with the achievement of a reduction of bleeding and pocket depth. There are several works in literature about the efficacy of lasers and LEDs, not only in oral surgery but even in other fields of dentistry, especially in the management of periodontitis and periimplantitis and in orthodontics, [32][33][34][35][36][37][38][39][40][41]. This success is explained by a series of characteristics specific to laser technology, in fact, thanks to the photoacoustic, photochemical, photothermal and photomechanical properties, the laser makes it possible to reduce bacterial load at the intervention site [32][33][34][35][36][37].…”

Section: Discussionmentioning

confidence: 99%

“…This success is explained by a series of characteristics specific to laser technology, in fact, thanks to the photoacoustic, photochemical, photothermal and photomechanical properties, the laser makes it possible to reduce bacterial load at the intervention site [32][33][34][35][36][37]. Another important feature is the photobiomodulation properties of laser and LEDs; at the bone level, it promotes the healing process in the post-surgical period and reduces post-surgical pain [38], as well as the orthodontic pain [39][40][41][42].…”

Section: Discussionmentioning

confidence: 99%

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Activated Plasma Albumin Gel (APAG) in Transalveolar Technique for Maxillary Sinus Lift: A Case Series

et al. 2022

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Over the past 20 years, transalveolar techniques have progressively improved. They have become increasingly predictable and reliable, with the additional advantage of simplified procedures that are less operator dependent. The aim of this study is to evaluate the effectiveness of a new technique to lift the maxillary sinus through a transalveolar approach, Simple Minimal Safe (SMS), with use of activated plasma albumin gel (APAG). A total of 33 patients (22 female and 11 male), aged between 36 and 79, were consecutively operated on, with 44 implants positioned using the SMS technique. All were placed in the premolar or molar areas of the maxillary bone. No implant was lost during the follow-up period (6 months) and all implants were then prosthetically loaded. The average bone gain was 4.43 mm. In the first quadrant, sites 15, 16 and 17 were involved with an average bone gain of 3.5 mm, 4.6 mm and 4.5 mm, respectively. In the second quadrant the sites 24, 25, 26 and 27 were involved with an average bone gain of 4.25 mm, 4.5 mm, 4.4 mm and 4.5 mm, respectively. Analyzing the data considering the sex, implants in women had an average gain of 4.66 mm, while in men the average gain was 3.83 mm. With the SMS technique, we achieved a reduction in post-operatory morbidity and in the frequency of Schneiderian membrane perforation. In conclusion, maxillary sinus augmentation via the transalveolar approach has become a more predictable surgical procedure and an easier technique due to less operator-dependent processes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Activated Plasma Albumin Gel (APAG) in Transalveolar Technique for Maxillary Sinus Lift: A Case Series

et al. 2022

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“…The former study showed that the ozone group presented with statistically significantly smaller wounds as compared with the control, while the latter study showed that lasers and ozone applications after gingivectomy and gingivoplasty reduced the pain levels of patients and had a positive effect on the patients’ quality of life. When used in conjunction with H 2 O 2 , one study showed new bone formation and wound healing by secondary intention in sites treated with oxygen high-level laser therapy (OHLLT), a high-frequency and high-power diode laser combined with hydrogen peroxide (10 volume, 3%) [ 120 ].…”

Section: Other Means (Sound Light Biological and Chemical Derivatives...mentioning

confidence: 99%

A Narrative Review on Means to Promote Oxygenation and Angiogenesis in Oral Wound Healing

et al. 2022

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Oral mucosa serves as the primary barrier against pathogen invasions, mechanical stresses, and physical trauma. Although it is generally composed of keratinocytes and held in place by desmosomes, it shows variation in tissue elasticity and surface keratinization at different sites of the oral cavity. Wound healing undergoes four stages of tissue change sequences, namely haemostasis, inflammation, proliferation, and remodelling. The wound healing of oral hard tissue and soft tissue is largely dependent on the inflammatory response and vascular response, which are the targets of many research. Because of a less-robust inflammatory response, favourable saliva properties, a unique oral environment, and the presence of mesenchymal stem cells, oral wounds are reported to demonstrate rapid healing, less scar formation, and fewer inflammatory reactions. However, delayed oral wound healing is a major concern in certain populations with autoimmune disorders or underlying medical issues, or those subjected to surgically inflicted injuries. Various means of approach have been adopted to improve wound tissue proliferation without causing excessive scarring. This narrative review reappraises the current literature on the use of light, sound, mechanical, biological, and chemical means to enhance oxygen delivery to wounds. The current literature includes the use of hyperbaric oxygen and topical oxygen therapy, ultrasounds, lasers, platelet-rich plasma (PRP)/platelet-rich fibrin (PRF), and various chemical agents such as hyaluronic acid, astaxanthin, and Centella asiatica to promote angiogenesis in oral wound healing during the proliferation process. The arrival of a proprietary oral gel that is reported to improve oxygenation is highlighted.

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“…Multiple studies have demonstrated the effectiveness of dye-free photodynamic therapy in managing chronic periodontitis through the implementation of a clinical and microbiological assessment utilizing PCR Real-Time Tests [27,28]. The Oxygen High-Level Laser Therapy (OHLLT) protocol [29][30][31] involves the utilization of a diode laser (Wiser, Lambda, Vicenza, Italy) in conjunction with a hydrogen peroxide-based solution known as the Sioxil ® solution (Lambda, Vicenza, Italy). This solution contains hydrogen peroxide stabilized at 10 volumes (3%), which has been purified to remove cytotoxic residues.…”

Section: Introductionmentioning

confidence: 99%

Pain Perception Following Periodontal Decontamination Treatment with Laser Therapies: Comparison between Oxygen High-Level Laser Therapy (OHLLT) and Laser-Assisted New Attachment Procedure (LANAP)

Caccianiga,

Ceraulo,

Rey

et al. 2024

Applied Sciences

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Introduction: Within the field of periodontology, there has been a proposal for the utilization of noninvasive laser therapy as a potential treatment for persistent periodontitis. The Laser-Assisted New Attachment Procedure (LANAP) employs an Nd:YAG laser as a specific technique. Through its interaction with endogenous chromophores, the Nd: YAG laser exhibits a selective effect on the evaporation of granulation tissue, therefore establishing a correlation with reduced bleeding. The study also examined Oxygen High-Level Laser Therapy (OHLLT). The OHLLT technique employs a high-power diode laser in combination with hydrogen peroxide solutions to facilitate the liberation of singlet oxygen, which possesses antibacterial attributes, within the periodontal pockets. The existing literature indicates their potential to promote the regeneration of tooth support tissues. Objective: The aim of this study is to assess the subjective pain levels reported by patients who have undergone surgery using the OHLLT protocol versus those who have undergone surgery using the LANAP technique. Methods: A total of 20 individuals with a stage III–IV periodontitis diagnosis were recruited for the study. The participants were randomly divided into two groups, each consisting of 10 individuals: Group 1, comprising patients treated according to the LANAP protocol, and Group 2, comprising patients treated according to the OHLLT protocol. After their initial session of nonsurgical periodontal therapy, individuals provided feedback regarding their level of pain, utilizing a Numerical Rating Scale (NRS) comprising time intervals of 0 h (T0), 6 h (T1), 12 h (T2), 24 h (T3), 48 h (T4), and 7 days (T5). The Wilcoxon–Mann–Whitney statistical test was employed to assess the variations in NRS scores between Group 1 and Group 2 at each recording period. (p ≤ 0.05). In addition, a microbiological assessment of the bacterial load in the periodontal region was conducted on all subjects using real-time PCR testing at two time points: prior to treatment (T0) and seven days post-treatment (T5). Results: The findings of this study indicate that the OHLLT group exhibited significantly lower pain levels compared to the LANAP group at all time intervals, except for the preoperative period, where no significant difference was observed (p < 0.05). Group 2 exhibited a more rapid decrease in pain, as demonstrated by a score test approaching zero within 24 h. The quantity of periodontal bacteria seen seven days post-treatment was similar between the two groups and was found to be decreased compared to the pre-treatment levels. Conclusions: The OHLLT and LANAP regimens have demonstrated efficacy in the nonsurgical management of periodontal disease. Nevertheless, it should be noted that the OHLLT approach does not subject the patient to any thermal hazards, unlike the LANAP method. The postoperative discomfort experienced following the OHLLT procedure is indeed reduced, as this technique is characterized by lower invasiveness and reduced dependence on the operator.

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Laser Decontamination and LED Photobiomodulation Promote Bone Regeneration and Wound Healing by Secondary Intention, in Alveolar Ridge Preservation—Clinical and Radiographic Evaluation: A Pilot Experience

Cited by 10 publications

References 54 publications

Activated Plasma Albumin Gel (APAG) in Transalveolar Technique for Maxillary Sinus Lift: A Case Series

Activated Plasma Albumin Gel (APAG) in Transalveolar Technique for Maxillary Sinus Lift: A Case Series

A Narrative Review on Means to Promote Oxygenation and Angiogenesis in Oral Wound Healing

Pain Perception Following Periodontal Decontamination Treatment with Laser Therapies: Comparison between Oxygen High-Level Laser Therapy (OHLLT) and Laser-Assisted New Attachment Procedure (LANAP)

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