Laser diffraction for standardization of heterogeneous pharmaceutical preparations

Сыроешкин, А. В.; Popov, P. I.; Гребенникова, Т. В.; Фролов, В. А.; Pleteneva, T. V.

doi:10.1016/j.jpba.2004.10.049

Cited by 13 publications

(6 citation statements)

References 2 publications

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“…Metabolic Activity. Particle size analysis (numerical and volume distribution of particle size/dimension spectra) and dissolution kinetics of powders of different dispersity ranges were recorded by the method of low-angle laser light scattering (LALLS) on diffraction particle analyzers [23] using Master Sizer 2000 instrument, Zeta Sizer Nano ZS instrument (MALVERN Instruments, UK), and "Cluster-1," IDL-1, laser meter of dispersion (manufactured by the Institute of Colloid Chemistry and Chemistry of Water, Ukraine; modification RUDN, Russia). Detailed description of the methods was presented in previous study [24,25].…”

Section: Laser Diffraction Methods For Assessing Cell Culturementioning

confidence: 99%

Comparative Analysis of the Different Dyes’ Potential to Assess Human Normal and Cancer Cell Viability In Vitro under Different D/H Ratios in a Culture Medium

Zlatskiy

Zlatska

Антипова

et al. 2020

The Scientific World Journal

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In this study, using new approach (laser diffraction + biological dyes), we have demonstrated the decrease of cells viability in vitro in the deuterated growth medium, whereas in the deuterium-depleted medium, there was an increase of cell viability. We have also found that not all dyes are equally sensitive to the D/H ratios in the culture medium (system) as well as to the different cell types (cancer vs normal cells).

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Section: Laser Diffraction Methods For Assessing Cell Culturementioning

confidence: 99%

Comparative Analysis of the Different Dyes’ Potential to Assess Human Normal and Cancer Cell Viability In Vitro under Different D/H Ratios in a Culture Medium

Zlatskiy

Zlatska

Антипова

et al. 2020

The Scientific World Journal

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“…Particle size analysis (numerical and volume distribution of particle sizes/dimension spectra), dissolution kinetics of powders of different dispersity were recorded by the method of Low-angle laser light scattering (LALLS) on diffraction particle analyzers [13] using Master Sizer 2000 instrument, Zeta Sizer Nano ZS instrument (MALVERN Instruments, UK) and "Cluster−1"-IDL-1, laser meter of dispersion (manufactured by the Institute of Colloid Chemistry and Chemistry of Water, Ukraine; RUDN, Russia).…”

Section: Laser Diffraction Methodsmentioning

confidence: 99%

Mechanochemical Activation of Pharmaceutical Substances as a Factor for Modification of Their Physical, Chemical and Biological Properties

et al. 2019

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Objective: Study the influence of the mechanical preparation methods (grinding, fluidization) of solid pharmaceutical substances (PS) and herbal raw material on their physicochemical properties and biological activities. Methods: Test substances and solvents-Lactose monohydrate (DFE Pharma, Germany). Sodium chloride, bendazol hydrochloride (all Sigma-Aldrich, USA) and herbal raw material (Callisia fragrans). The dispersity and native structure of pharmaceutical substances were analyzed by several methods: optical microscopy–Altami BIO 2 microscope (Russia); low angle laser light scattering (LALLS) method (Malvern Instruments, UK); Spirotox method–Quasichemical kinetic of cell transition of cellular biosensor Spirostomum ambiguum; Fourier-transform infrared spectroscopy–the analysis in the middle IR region was carried out using an IR Cary 630 Fourier spectrometer (Agilent Technologies, USA). The analysis of dried leaves of C. fragrans before and after mechanical activation was performed using Shimadzu EDX-7000 X-ray fluorescence spectrophotometer without mineralization (Shimadzu, Japan). Results: It was established that the mechanical change, such as dispersion and drying, alters the biological activity of PS and herbal raw materials. The observed increase in the influence of the dispersed substance on the biosensor S. ambiguum is quantitatively estimated from the values of the activation energy (obsEa), which turns to be valued 1,5 (P≤0,05) times more than for the native form substance. In the study of the dependence of the availability of chemical elements K, Ca, Zn on the degree of dispersion of herbal raw materials was established a quantitative 4-fold (P≤0,05) increase in the concentration of elements in mechano-activated raw materials. Conclusion: By the example of the biological model of Spirotox (single-celled biosensor S. ambiguum) and herbal raw materials obtained from C. fragrans, the increase of biological activity of PS at the dispersion of initial preparations was proved.

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“…The determination of deuterium content in water samples obtained in industrial and laboratory manners was performed by static low−angle laser light scattering (LALLS) using the Master Sizer 2000 instrument, Zeta Sizer Nano ZS instrument (MALVERN Instruments, UK) and "Cluster-1"/MDL-1, laser meter of dispersion (manufactured by the Institute of Colloid Chemistry and Chemistry of Water, Ukraine and RUDN University, Russia) [35]. Laser scattering occurs on optical in homogeneities of the medium that appear when the refractive index changes [36].…”

Section: Laser Diffraction Methodsmentioning

confidence: 99%

Light Scattering in Research and Quality Control of Deuterium Depleted Water for Pharmaceutical Application

et al. 2019

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Objective: Development of a methodology for measuring the deuterium content in water for pharmaceutical purposes by laser light scattering based on ideas about the cluster structure of water. Methods: Samples of industrially manufactured drinking water from different manufacturers with varying deuterium content from 10 ppm to 115 ppm. For the titration of laboratory samples of deuterium depleted water in increments of 5 ppm the following reagents were used: Water, deuterium-depleted (≤1 ppm (D2O, Aldrich, USA); Deuterium oxide/Heavy water/Water-d2 (99.9 atom % D, Aldrich, USA); water Milli-Q (specific resistance 18.2 µS·sm at 25 оС, ТОС ≤ 5 ppb, Merck Millipore). The determination of deuterium content in samples of industrially manufactured water and water obtained in a laboratory manner was carried out by the method of low-angle laser light scattering (LALLS) at the Mastersizer (Malvern Instruments) analyzer and using a working measuring tool–laser dispersion meter/MDL («Cluster-1», Russia/Ukraine). The statistical methods–packages OriginPro®9. Results: It was found that the content of isotopologies in water leads to physicochemical water’s properties changes and morphology changes of giant heterogeneous clusters (GHC). The results of low-angle laser light scattering (LALLS) in the water samples under investigation showed the dependence of the water GHC "dispersibility" expressed in the differentiation of curves of the volume size distribution ("size spectra"), the volume concentration, w%, the laser obscuration values (I ‒I0) as the function of the water isotopic composition variations. The laser diffraction method results correlate with two-dimensional (2D) multi-descriptor mathematical analysis. Conclusion: When identifying deuterium depleted water, it should be considered not only the indicators that determine its pharmacopoeial quality, but also the D/H ratio, because even small changes in the natural isotopic composition of water lead to significant biological effects. Our proposed approach using laser diffraction in combination with mathematical apparatus of (2D) multi-descriptor laser scattering analysis makes possible the exact calculation of individual signs of deuterium depleted water as the pharmaceutical object of study.

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Laser diffraction for standardization of heterogeneous pharmaceutical preparations

Cited by 13 publications

References 2 publications

Comparative Analysis of the Different Dyes’ Potential to Assess Human Normal and Cancer Cell Viability In Vitro under Different D/H Ratios in a Culture Medium

Comparative Analysis of the Different Dyes’ Potential to Assess Human Normal and Cancer Cell Viability In Vitro under Different D/H Ratios in a Culture Medium

Mechanochemical Activation of Pharmaceutical Substances as a Factor for Modification of Their Physical, Chemical and Biological Properties

Light Scattering in Research and Quality Control of Deuterium Depleted Water for Pharmaceutical Application

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