Laser Doppler flowmetry detection of endothelial dysfunction in end-stage renal disease patients: Correlation with cardiovascular risk

Kruger, Adam; Stewart, Julian M.; Sahityani, Rachna; O’Riordan, Edmond; Thompson, Carl I.; Adler, Stephen; Garrick, R.; Vallance, Patrick; Goligorsky, Michael S.

doi:10.1038/sj.ki.5001511

Cited by 113 publications

(103 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Impaired skin microvascular reactivity has been associated with increased cardiovascular risk in a number of studies, including those looking at coronary heart disease, 17 hypertension 18 and renal disease. 19 Previous studies have explored the relationship between early infant factors and later microvascular function, and have mainly looked at the role of low birth weight, although the findings have been inconsistent. Martin and colleagues reported reduced responses to ACh in 9-year-old children with a low birth weight, 11 whereas Ijzerman and colleagues found no effect of low birth weight on ACh responses.…”

Section: Discussionmentioning

confidence: 99%

The beneficial effects of breastfeeding on microvascular function in 11- to 14-year-old children

et al. 2009

View full text Add to dashboard Cite

Infant feeding practices have an impact on health in later life, although the evidence for its effects on cardiovascular health is not so clear. The aim of this study was to investigate the relationship between breastfeeding in infancy and vascular function in later childhood. Infant feeding data, together with demographic and clinical information, were obtained prospectively from a cohort of children from birth until 2 years of age. Vascular function was assessed in 159 children, now aged 11-14 years, by measuring their skin microvascular responses to iontophoretic administration of the endothelium-dependent vasodilator acetylcholine. Endothelial function was significantly better in children who had been breastfed than in those who had received infant milk formula (p = 0.001), after adjustment for potential confounding factors. Linear regression showed that acetylcholine responses were significantly related to the duration of breastfeeding (r = 0.30, p = 0.006). The risk of later cardiovascular disease may be reduced by exclusively breastfeeding during infancy. These findings have potential public health implications, and support policies aimed at promoting breastfeeding.

show abstract

Section: Discussionmentioning

confidence: 99%

The beneficial effects of breastfeeding on microvascular function in 11- to 14-year-old children

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Structural and mechanical degradation with severe and progressive atherosclerosis in the abdominal aorta is observed. [31][32][33][34][35][36] Indeed, this heterogeneity is associated with differences in age-related segmental changes of aortic diameters. In general populations, the aging is associated with gradually decreasing slopes (b-coefficients) of diameter-age relationships along the aorta.…”

Section: Discussionmentioning

confidence: 99%

“…[37][38][39][40] Decreased postocclusion or thermal muscular and cutaneous hyperemia was observed in patients with ESRD and associated with cardiovascular risk and increased mortality. 36,37,40 These abnormalities reflect reduced microvascular and capillary density, abnormal vessel recruitment, structural changes of the microvasculature, and endothelial dysfunction. [36][37][38][39][40] In the investigation, the effect of aortic and arterial changes on outcomes of patients with ESRD was studied using Cox models and receiver operating characteristic curves ( Figure 5, Tables 6 and 7).…”

Section: Discussionmentioning

confidence: 99%

“…36,37,40 These abnormalities reflect reduced microvascular and capillary density, abnormal vessel recruitment, structural changes of the microvasculature, and endothelial dysfunction. [36][37][38][39][40] In the investigation, the effect of aortic and arterial changes on outcomes of patients with ESRD was studied using Cox models and receiver operating characteristic curves ( Figure 5, Tables 6 and 7). The only arterial parameters associated with all-cause and cardiovascular mortality are increased aortic PWV and aortic bifurcation diameter, which are both significantly associated with premature arterial aging in ESRD.…”

Section: Discussionmentioning

confidence: 99%

“…The abnormal age-diameter relationship was associated with extensive abdominal aortic calcifications (Figure 3), characteristic in patients with ESRD and strongly associated with aortic stiffness. [33][34][35][36] To analyze the effect of age-associated arterial properties on pressure-wave propagations, we estimated the global reflection coefficient-the percentage of incident pressure waves reflected in controls and patients with ESRD. The controls global reflection coefficient was higher (0.8260.06) ( Table 1), relatively close to that observed for the whole systemic circulation in an experimental setting.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Aortic Aging in ESRD: Structural, Hemodynamic, and Mortality Implications

London

Safar

Pannier

2015

JASN

View full text Add to dashboard Cite

Aging incurs aortic stiffening and dilation, but these changes are less pronounced in peripheral arteries, resulting in stiffness and geometry gradients influencing progression of the forward and reflected pressure waves. Because premature arterial aging is observed in ESRD, we determined the respective roles of stiffness and aortic geometry gradients in 73 controls and 156 patients on hemodialysis. We measured aortic pulse wave velocity (PWV) and brachial PWV to evaluate the stiffness gradient [(brachial PWV/aortic PWV) 0.5 ] and ascending aortic and aortic bifurcation diameters to assess aortic taper (ascending aortic diameter/aortic bifurcation diameter). The global reflection coefficient was estimated from characteristic impedance and vascular resistance. Cox proportional hazard models were used to determine mortality risk. The age-associated increase in aortic PWV was higher in patients (P,0.001). In controls, aortic ascending and bifurcation diameters increased with age, with an unchanged aortic taper. In patients on hemodialysis, age did not associate with increased ascending aortic diameter but did associate with increased aortic bifurcation diameter and decreased aortic taper, both of which also associated with abdominal aortic calcifications and smaller global reflection coefficient (P,0.001). In patients, multivariate models revealed all-cause and cardiovascular mortality associated with age, aortic PWV, and aortic bifurcation diameter with high specificity and sensitivity. Using stiffness gradient, aortic taper, or global reflection coefficient in the model produced similar results. Thus, whereas aortic stiffness is a known independent predictor of mortality, these results indicate the importance of also evaluating the aortic geometry in patients on hemodialysis. 27: 183727: -184627: , 201627: . doi: 10.1681 Aging is associated with marked changes in the mechanical and geometric characteristics of the arterial tree. 1 It is characterized by markedly increased aortic stiffness (aortic pulse wave velocity [PWV]), stiffening not observed to the same degree in peripheral muscular arteries. 2 This change reduces the normal centrifugal impedance gradient between central and peripheral artery systems. 2,3 Any change of the impedance gradient generates modifications of partial local wave reflections, which can be considered a continuous phenomenon along the impedance gradient. 3,4 The partial reflections summate to form an apparently unique backward-traveling reflected wave. 5 In the presence of impedance gradient and low aortic PWV, the backward wave returns to the aorta at end systole and early diastole, thereby enhancing late diastolic pressure and coronary perfusion 4 and attenuating the transmission of pulsatile pressure to the microcirculation. 3,6 The central effect of aortic stiffness on impedance J Am Soc Nephrol

show abstract

Cutaneous Vasodilator and Vasoconstrictor Mechanisms in Temperature Regulation

Johnson

Minson

Kellogg

2014

Comprehensive Physiology

338

290

View full text Add to dashboard Cite

In this review, we focus on significant developments in our understanding of the mechanisms that control the cutaneous vasculature in humans, with emphasis on the literature of the last half-century. To provide a background for subsequent sections, we review methods of measurement and techniques of importance in elucidating control mechanisms for studying skin blood flow. In addition, the anatomy of the skin relevant to its thermoregulatory function is outlined. The mechanisms by which sympathetic nerves mediate cutaneous active vasodilation during whole body heating and cutaneous vasoconstriction during whole body cooling are reviewed, including discussions of mechanisms involving cotransmission, NO, and other effectors. Current concepts for the mechanisms that effect local cutaneous vascular responses to local skin warming and cooling are examined, including the roles of temperature sensitive afferent neurons as well as NO and other mediators. Factors that can modulate control mechanisms of the cutaneous vasculature, such as gender, aging, and clinical conditions, are discussed, as are nonthermoregulatory reflex modifiers of thermoregulatory cutaneous vascular responses.

show abstract

Laser Doppler flowmetry detection of endothelial dysfunction in end-stage renal disease patients: Correlation with cardiovascular risk

Cited by 113 publications

References 16 publications

The beneficial effects of breastfeeding on microvascular function in 11- to 14-year-old children

The beneficial effects of breastfeeding on microvascular function in 11- to 14-year-old children

Aortic Aging in ESRD: Structural, Hemodynamic, and Mortality Implications

Cutaneous Vasodilator and Vasoconstrictor Mechanisms in Temperature Regulation

Contact Info

Product

Resources

About