Laser Doppler flux measurement for the assessment of cutaneous microcirculation – critical remarks

Jung, F.; Leithäuser, Boris; Landgraf, H.; Jünger, Michael; Uk, Franzeck; Pries, Axel R.; Sternitzky, R; Franke, R.P.; Forconi, S; Ehrly, A. M.

doi:10.3233/ch-131778

Cited by 36 publications

(15 citation statements)

References 9 publications

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Section: Vasomotionmentioning

confidence: 99%

“…The microcirculation consists of the smallest order of blood vessels, with a diameter of <150 µm [66,67]. On this circulatory level, oxygen and nutrients are exchanged between the blood and the tissue [66,67]. A functioning microcirculation is essential to any organism and the microcirculation has therefore been of great interest to better understand many physiological and pathophysiological conditions.…”

Section: Vasomotionmentioning

confidence: 99%

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Blood Flow Dynamics in Burns

Mirdell

2019

Linköping University Medical Dissertations

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Burns of intermediate thickness are hard to evaluate clinically. This often leads to unnecessary delays of up to 14 days before a surgical decision can be made. To counter this, several objective methods have been developed to determine the healing potential of the wound. Over the years, measurement of perfusion has proven to be the most successful method for evaluation of healing potential. Laser Doppler imaging (LDI) is currently the most used method and can determine surgical need 2 days after injury with an accuracy >90%. There are however emerging techniques like laser speckle contrast imaging (LSCI), which also measure perfusion. LSCI have several advantages over LDI and is easier to use. LSCI can also investigate aspects of the microcirculation, previously not possible with LDI. The aim of this thesis was to investigate LSCI's ability to evaluate surgical need in burns of indeterminate partial-thickness. The first objective was to investigate the dynamics of perfusion the first 14 days after injury. The purpose was to find the optimal time-window for perfusion measurements. The next goal was to determine the accuracy of different perfusion cutoffs. In this second study, the benefit of a subsequent measurement was also investigated. After this, interobserver variation between different profession groups was studied. Both the agreement of perfusion measurements and observer assessments were evaluated. Finally, cardiac vasomotion in combination with perfusion (pulsatility) was investigated as a method to determine surgical need <48 hours after injury. Methods:

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Section: Vasomotionmentioning

confidence: 99%

Section: Vasomotionmentioning

confidence: 99%

Blood Flow Dynamics in Burns

Mirdell

2019

Linköping University Medical Dissertations

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“…Although the skin has a relatively wide ischemic tolerance, the border or reversible and irreversible alterations are still unknown. Investigating this issue, various techniques for monitoring flap perfusion and microcirculation provide useful data 12,[16][17][18][19][20][21][22][23] .…”

Section: ■ Introductionmentioning

confidence: 99%

Effect of short-term ischemia on microcirculation and wound healing of adipocutaneous flaps in the rat

et al. 2019

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“…Nevertheless, as revealed by Jung [18] or Podtaev [9], local probes were used in many of these studies, which had two main disadvantages. The first one was the limitation to a small skin surface while the second was the marked variability in the results, depending highly on the probe location.…”

Section: Introductionmentioning

confidence: 99%

Proposal for a protocol using an infrared microbolometer camera and wavelet analysis to study foot thermoregulation

Serantoni

Jourdan

Louche

et al. 2019

Quantitative InfraRed Thermography Journal

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Here we propose a protocol to: (i) generate skin temperature (SkT) oscillations on glabrous tissues (plantar foot) in healthy subjects under controlled clinical environment conditions; (ii) measure quantitative temperature fields with an inexpensive microbolometer 2 (MB) infrared camera in a clinical environment; and (iii) quantify the characteristics of skin temperature (SkT) oscillations through spectral analysis. We paid particular attention to the metrology of thermal measurements, with a special bench, including four homemade black body reference areas. We propose a live calibration procedure using this setup while correcting the thermal drift. After all of these correction steps, the experimental thermal resolution () for the temporal variation in each pixel was about 25. Finally, a movement removal procedure was also applied to the thermal images to avoid foot spatial movement over the 10 min observation period. Thermoregulation was stimulated by a 6-min walking exercise test on six volunteers and was then studied using three kinds of scalar indicators evaluated before and after exercise per thermal image pixel. We demonstrated that the 6-min walk exercise increased the thermoregulation activity beneath the plantar foot sole. Moreover, unlike manually placed local thermal probes, the indicator fields proposed in this paper allow the operator to select the exact thermoregulation activation locations and analyse the spatial distribution patterns at these locations.

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Laser Doppler flux measurement for the assessment of cutaneous microcirculation – critical remarks

Cited by 36 publications

References 9 publications

Blood Flow Dynamics in Burns

Blood Flow Dynamics in Burns

Effect of short-term ischemia on microcirculation and wound healing of adipocutaneous flaps in the rat

Proposal for a protocol using an infrared microbolometer camera and wavelet analysis to study foot thermoregulation

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