Laser-driven ion accelerators for tumor therapy revisited

Linz, Ute; Alonso, J.

doi:10.1103/physrevaccelbeams.19.124802

Cited by 56 publications

(28 citation statements)

References 39 publications

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“…Laser-accelerated ions are still far from clinical use [43]. For instance, accelerating with laser pulses protons up to 200 MeV, the energies required for protontherapy, remains a major challenge that is currently motivating numerous research studies in the scientific community.…”

Section: Discussionmentioning

confidence: 99%

Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments

Pommarel

Vauzour

Mégnin-Chanet

et al. 2017

Phys. Rev. Accel. Beams

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International audienceThe study of radiation biology on laser-based accelerators is most interesting due to the unique irradiation conditions they can produce, in terms of peak current and duration of the irradiation. In this paper we present the implementation of a beam transport system to transport and shape the proton beam generated by laser-target interaction for in vitro irradiation of biological samples. A set of four permanent magnet quadrupoles is used to transport and focus the beam, efficiently shaping the spectrum and providing a large and relatively uniform irradiation surface. Real time, absolutely calibrated, dosimetry is installed on the beam line, to enable shot-to-shot control of dose deposition in the irradiated volume. Preliminary results of cell sample irradiation are presented to validate the robustness of the full system

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Section: Discussionmentioning

confidence: 99%

Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments

Pommarel

Vauzour

Mégnin-Chanet

et al. 2017

Phys. Rev. Accel. Beams

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“…Historically, the foreseen societal application in radiotherapy [8,9] has been a preeminent driving force behind research efforts on laser-driven ion acceleration. However, existing laser-driven ion sources still fall short of the stringent requirements in terms of energy, monochromaticity and stability [10]. Indeed, up to now, laser-driven ion sources have been routinely used only as a diagnostic tool for transient electromagnetic fields in laser-plasma interaction experiments [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Enhanced laser-driven hadron sources with nanostructured double-layer targets

et al. 2020

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Laser-driven ion sources are approaching the requirements for several applications in materials and nuclear science. Relying on compact, table-top, femtosecond laser systems is pivotal to enable most of these applications. However, the moderate intensity of these systems (I10 19 W cm −2 ) could lead to insufficient energy and total charge of the accelerated ions. The use of solid foils coated with a nanostructured near-critical layer is emerging as a promising targeted solution to enhance the energy and the total charge of the accelerated ions. For an appropriate theoretical understanding of this acceleration scheme, a realistic description of the nanostructure is essential, also to precisely assess its role in the physical processes at play. Here, by means of 3D particle-in-cell simulations, we investigate ion acceleration in this scenario, assessing the role of different realistic nanostructure morphologies, such as fractal-like foams and nanowire forests. With respect to a simple flat foil, the presence of a nanostructure allows for up to a×3 increase of the maximum ion energy and for a significant increase of the conversion efficiency of laser energy into ion kinetic energy. Simulations show also that the details of the nanostructure morphology affect both the maximum energy of the ions and their angular distribution. Furthermore, combined 3D particle-in-cell and Monte Carlo simulations show that if accelerated ions are used for neutron generation with a beryllium converter, double-layer nanostructured targets allow to greatly enhance the neutron yield. These results suggest that nanostructured double-layer targets could be an essential component to enable applications of hadron sources driven by compact, table-top lasers. feasibility of laser-driven ion beam analysis for non-destructive materials characterization. Laser-driven ion sources have been considered to test electronic components in a harsh radiation environment [18], for thermal stress testing [19], to study ultra-fast dynamics in irradiated materials [20,21], and for materials synthesis [22,23]. Ultrashort pulsed neutron sources driven by laser-accelerated ions [24-32] have been investigated for applications such as fast neutron spectroscopy [33] and radiography [34].What make these applications particularly attractive are the requirements for the ion source. Energies of few MeVs are perfectly suitable for several ion beam analysis techniques [35] or to generate neutrons with a lithium [36] or beryllium [37] converter. Moreover, for selected applications, the inherently broad energy spectrum of a laser-driven ion source [2] is not detrimental [15,17] and could even be beneficial [18]. Maximum ion energies of ∼1 MeV have been recently demonstrated even with commercial, sub-terawatt laser systems [38]. These lasersystems are truly table-top and can operate at a high repetition rate (kiloHertz). Relying on these systems could make laser-driven ion sources portable and competitive with conventional accelerators, paving the way for their widesprea...

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“…As a high contrast laser pulse and ultrahigh laser intensity are necessary for the RPA/BOA regime, therefore so far quite few results are reported. Although significant progress has been made in this field, argument also exists that the laser accelerator will not be able to replace conventional ones any time soon because of the proton energy, flux, shot-to-shot reproducibility, accurate dose control, and so on [20]. For example, the typical exponentially decaying spectrum of laser-accelerated protons is far from performance levels for many applications.…”

Section: Introductionmentioning

confidence: 99%

Experimental demonstration of a laser proton accelerator with accurate beam control through image-relaying transport

Zhu

Liao

et al. 2019

Phys. Rev. Accel. Beams

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A compact laser plasma accelerator (CLAPA) that can stably produce and transport proton ions with different energies less than 10 MeV, <1% energy spread, several to tens of pC charge, is demonstrated. The high current proton beam with continuous energy spectrum and a large divergence angle is generated by using a high contrast laser and micron thickness targets, which later is collected, analyzed and refocused by an image-relaying beam line using a combination of quadrupole and bending electromagnets. It eliminates the inherent defects of the laser-driven beams, realizes precise manipulation of the proton beams with reliability, availability, maintainability and inspectability (RAMI), and takes the first step towards applications of this new generation of accelerator. With the development of high-rep rate Petawatt (PW) laser technology, we can now envision a new generation of accelerator for many applications in the near future soon.

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Laser-driven ion accelerators for tumor therapy revisited

Cited by 56 publications

References 39 publications

Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments

Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments

Enhanced laser-driven hadron sources with nanostructured double-layer targets

Experimental demonstration of a laser proton accelerator with accurate beam control through image-relaying transport

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