Laser facilitated epicutaneous peptide immunization using dry patch technology

Scheiblhofer, Sandra; Drothler, Stephan; Braun, Werner; Braun, Reinhard; Boesch, Maximilian; Weiss, Richard

doi:10.1016/j.vaccine.2021.07.083

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…46 Laser ablation works by creating a micropore structure in the skin and increasing the skin temperature, which in turn enhances skin diffusivity. 9 A number of earlier investigations have revealed that the use of the laser ablation method enables the penetration and absorption of macromolecules, 47 hydrophilic compounds, 48 vitamin C, and growth factors through the skin. 49 In the beginning, fully-ablative lasers were used to make TDD more effective.…”

Section: Thermal Ablationmentioning

confidence: 99%

Enhancement of drug permeation across skin through stratum corneum ablation

Abdoh,

Liu,

Mohammed

2024

RSC Pharm.

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Section: Thermal Ablationmentioning

confidence: 99%

Enhancement of drug permeation across skin through stratum corneum ablation

Abdoh,

Liu,

Mohammed

2024

RSC Pharm.

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Advancing immunotherapy using biomaterials to control tissue, cellular, and molecular level immune signaling in skin

Shah,

Oakes,

Jewell

2024

Advanced Drug Delivery Reviews

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Laser Adjuvants: Key Features and Specificity

Zayneeva

Gil'mutdinova

Zolotovskii

et al. 2022

Ulyanovsk Medico-biological Journal

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Increasing the vaccine effectiveness and the search for new adjuvants that directly influence immunocompetent cells and stimulate the development of a pronounced adaptive immune response remain significant problems for modern medicine. Currently, aluminum salts and other chemicals with certain side effects are used as adjuvants. Therefore, it is relevant to search for other methods to increase vaccine effectiveness while reducing its toxic effect on the patients. One of such methods is laser irradiation of the injection sites, which, among other things, makes it possible to reduce vaccine amount. The purpose of this review is to analyze publications on the use of laser to stimulate the immune response. Four different classes of lasers are known to systemically enhance the immune response to intradermal vaccination: pulsed lasers, continuous mode lasers, non-ablative fractional lasers, and ablative fractional lasers. Each laser vaccine adjuvant is characterized by radiation parameters, modes of action, and immunological adjuvant effects that differ significantly. The authors consider main classes of lasers used as immunological adjuvants. The specificity of each laser will help to choose the most effective option to achieve the clinical goal when using a particular vaccine.

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Laser facilitated epicutaneous peptide immunization using dry patch technology

Cited by 3 publications

References 35 publications

Enhancement of drug permeation across skin through stratum corneum ablation

Enhancement of drug permeation across skin through stratum corneum ablation

Advancing immunotherapy using biomaterials to control tissue, cellular, and molecular level immune signaling in skin

Laser Adjuvants: Key Features and Specificity

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