This study compared the short-and long-term clinical outcomes of laser hemorrhoidoplasty (LH) vs. conventional hemorrhoidectomy (CH) in patients with grade II/III hemorrhoids. Methods: PubMed/MEDLINE and the Cochrane Library were searched for randomized and nonrandomized studies comparing LH against CH in grade II/III hemorrhoids. The primary outcomes included postoperative use of analgesia, postoperative morbidity (bleeding, urinary retention, pain, thrombosis), and time of return to work/daily activities. Results: Nine studies totaling 661 patients (LH, 336 and CH, 325) were included. The LH group had shorter operative time (P < 0.001) and less intraoperative blood loss (P < 0.001). Postoperative pain was lower in the LH group, with lower postoperative day 1 (mean difference [MD], -2.09; 95% confidence interval [CI], -3.44 to -0.75; P = 0.002) and postoperative day 7 (MD, -3.94; 95% CI, -6.36 to -1.52; P = 0.001) visual analogue scores and use of analgesia (risk ratio [RR], 0.59; 95% CI, 0.42-0.81; P = 0.001). The risk of postoperative bleeding was also lower in the LH group (RR, 0.18; 95% CI, 0.12-0.28; P < 0.001), with a quicker return to work or daily activities (P = 0.002). The 12-month risks of bleeding (P > 0.999) and prolapse (P = 0.240), and the likelihood of complete resolution at 12 months, were similar (P = 0.240). Conclusion: LH offers more favorable short-term clinical outcomes than CH, with reduced morbidity and pain and earlier return to work or daily activities. Medium-term symptom recurrence at 12 months was similar. Our results should be verified in future well-designed trials with larger samples.