Laser in situ keratomileusis–induced optic neuropathy

Cameron, Bruce D; Saffra, Norman; Strominger, Mitchell B.

doi:10.1016/s0161-6420(00)00577-7

Cited by 96 publications

(60 citation statements)

References 2 publications

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“…Other risk factors that have been variably associated with NAION include nocturnal hypotension, severe anemia, hyperhomocysteinemia, coagulopathies, migraine, and smoking. NAION has also been observed during the perioperative period in intraocular surgery as well as in the earlier days of LASIK surgery when there was a significant elevation in intraocular pressure at the time of surgery (Cameron et al 2001;Lee et al 2000;Shetty et al 2007). Laser photocoagulation,295,311,315 Latanoprost,16,21,38,39,42,64,72,73,185,188,190,191,196,197,199 Latrunculins A and B,22 Leber's congenital amaurosis (LCA), 294, 343-345 Leber's hereditary optic neuropathy (LHON), 220,344,[354][355][356][378][379][380]348 Levobetaxolol,20,37,38 Levobunolol,36,39,186 Levofloxacin,18,67,124,170 LFG316,317,326 11,75,80,81,130,…”

Section: Introductionmentioning

confidence: 98%

Corticosteroids and Anti-Complement Therapy in Retinal Diseases

Narayanan

Kuppermann

2016

Handbook of Experimental Pharmacology

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Section: Introductionmentioning

confidence: 98%

Corticosteroids and Anti-Complement Therapy in Retinal Diseases

Narayanan

Kuppermann

2016

Handbook of Experimental Pharmacology

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“…To create a precise lamellar corneal flap, the intraocular pressure (IOP) must be elevated to above 65 mm Hg, and a suction ring vacuum is often used to maintain the IOP at around 65 mm Hg [1] . The maintenance of such a pressure around the eye suggests the possibility that application of a suction ring could cause a change in the conjunctiva or even conjunctival damage.…”

Section: Introductionmentioning

confidence: 99%

Conjunctival Changes Induced by LASIK Suction Ring in a Rabbit Model

Shin

Lee²

2006

Ophthalmic Res

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Purpose: To study histopathological changes in rabbit conjunctiva after suction ring application. Methods: A suction ring was applied to adult albino rabbit eyes (n = 30) with a vacuum pressure of 508 mm Hg for 40 s. Three rabbits were sacrificed at 3 h (3-hour group), 6 h (6-hour group), 1 day (1-day group), 3 days (3-day group), and 7 days (7-day group) after the suction ring application. Histopathological examinations included hematoxylin and eosin, Alcian blue pH 2.5-periodic acid-Schiff (AB2.5-PAS), and Alcian blue pH 1.0-periodic acid-Schiff (AB1.0-PAS) staining. TdT-dUTP-terminal nick-end labeling (TUNEL) assay and immunohistochemical staining for p65 were also performed. Results: The site of suction ring application and adjacent areas did not show transient inflammation. AB2.5-PAS staining revealed that the percentage of neutral mucin was significantly different between 54.5 ± 1.6% in the control group and 22.3 ± 1.3% in the 7-day group (p = 0.04). Apoptosis occurred not only at the site of suction ring application, but also in adjacent regions. At all time points, conjunctival epithelium showed no positive staining for p65. Conclusion: The transient elevation of pressure induced by a suction ring is sufficient to cause conjunctival damage. These histological results support the finding that conjunctival damage caused by suction ring application is one of many etiologies of dry eye syndrome following laser in situ keratomileusis.

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“…A técnica do LASIK (Laser in situ keratomileusis) está associada a idéia de recuperação rápida da acuidade visual e conforto no pós-operatório, por oftalmologistas e pacientes de cirurgia refrativa (1)(2)(3) . A confecção da lamela corneana pediculada, apesar de ser uma técnica segura e facilmente reprodutível, apresenta percentual de complicações em torno de 0,4% a 10%, e o manuseio dos microcerátomos está associado a uma curva de aprendizado (2)(3)(4)(5) .…”

Section: Introductionunclassified

“…A confecção da lamela corneana pediculada, apesar de ser uma técnica segura e facilmente reprodutível, apresenta percentual de complicações em torno de 0,4% a 10%, e o manuseio dos microcerátomos está associado a uma curva de aprendizado (2)(3)(4)(5) . As complicações geralmente estão relacionadas ao tempo de sucção ou ao microcerá-tomo e são descritas as eventuais perfurações corneanas, lamelas incompletas, irregulares, finas, sem pedículo ("free cap") e perfurada ("buttonhole") (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) . Estudam-se os fatores predisponentes para cada uma delas como ceratometria prévia, irregularidades corneanas, diâmetro corneano, sincronismo entre os motores de avanço e vibração da lâmina do microcerátomo, sucção e PO (pressão intra-ocular) inadequadas, assim como a melhor conduta para cada caso (2) .…”

Section: Introductionunclassified