Laser-induced acoustic desorption/chemical ionization in Fourier-transform ion cyclotron resonance mass spectrometry

Perez, James; Ramírez-Arizmendi, Luis E.; Kim, Young-Mo; Guler, Leonard P.; Nelson, Eric D.; Kenttämaa, Hilkka I.

doi:10.1016/s1387-3806(00)00181-0

Cited by 72 publications

(112 citation statements)

References 41 publications

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“…Both instruments were configured with a specially made guide ring for positioning of the LIAD probe with respect to the center of the ICR cell, as described previously. 10,14,20,21 Desorption is performed by focusing the laser beam of a Nd:YAG laser (532 nm, 3 ns pulse width) through an optical fiber (365 μm diameter, 3M Specialty Fibers, West Haven, CT) onto the back side of a Ti metal foil secured on the probe tip, as previously described. 10,14 The two transmission geometry probes are of different diameters (1/2″ and 7/8″).…”

Section: Liad Probesmentioning

confidence: 99%

Experimental Investigations of the Internal Energy of Molecules Evaporated via Laser-Induced Acoustic Desorption into a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer

et al. 2007

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The internal energy of neutral gas-phase organic and biomolecules, evaporated by means of laserinduced acoustic desorption (LIAD) into a Fourier-transform ion cyclotron resonance mass spectrometer (FT-ICR), was investigated through several experimental approaches. The desorbed molecules were demonstrated not to undergo degradation during the desorption process by collecting LIAD-evaporated molecules and subjecting them to analysis by electrospray ionization/quadrupole ion trap mass spectrometry. Previously established gas-phase basicity (GB) values were remeasured for LIAD-evaporated organic molecules and biomolecules with the use of the bracketing method. No endothermic reactions were observed. The remeasured basicity values are in close agreement with the values reported in the literature. The amount of internal energy deposited during LIAD is concluded to be less than a few kcal/mol. Chemical ionization with a series of proton transfer reagents was employed to obtain a breakdown curve for a protonated dipeptide, val-pro, evaporated by LIAD.Comparison of this breakdown curve with a previously published analogous curve obtained by using substrate-assisted laser desorption (SALD) to evaporate the peptide suggests that the molecules evaporated via LIAD have less internal energy than those evaporated via SALD.

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Section: Liad Probesmentioning

confidence: 99%

Experimental Investigations of the Internal Energy of Molecules Evaporated via Laser-Induced Acoustic Desorption into a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer

et al. 2007

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“…LIAD is accomplished by irradiating the backside of a metal foil~5-20 μm thick with a nanosecond laser pulse of power density~10 8 W/cm 2 . After absorption of this pulse, molecular species are ejected from the opposite side of the foil with relatively little energy transferred to the desorbed species [11,12]. Since LIAD is known to generate mostly neutral and intact molecules, this technique is well suited for softly producing pulses of low-polarity thermally-labile gas-phase molecules [11,13,14].…”

Section: Introductionmentioning

confidence: 99%

“…After absorption of this pulse, molecular species are ejected from the opposite side of the foil with relatively little energy transferred to the desorbed species [11,12]. Since LIAD is known to generate mostly neutral and intact molecules, this technique is well suited for softly producing pulses of low-polarity thermally-labile gas-phase molecules [11,13,14]. Initial studies describing the LIAD process suggested an acoustic wave mechanism for volatilization [15].…”

Section: Introductionmentioning

confidence: 99%

Laser-Induced Acoustic Desorption Atmospheric Pressure Photoionization via VUV-Generating Microplasmas

Benham

Hodyss

Fernández

et al. 2016

J. Am. Soc. Mass Spectrom.

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Abstract. We demonstrate the first application of laser-induced acoustic desorption (LIAD) and atmospheric pressure photoionization (APPI) as a mass spectrometric method for detecting low-polarity organics. This was accomplished using a Lyman-α (10.2 eV) photon generating microhollow cathode discharge (MHCD) microplasma photon source in conjunction with the addition of a gas-phase molecular dopant. This combination provided a soft desorption and a relatively soft ionization technique. Selected compounds analyzed include α-tocopherol, perylene, cholesterol, phenanthrene, phylloquinone, and squalene. Detectable surface concentrations as low as a few pmol per spot sampled were achievable using test molecules. The combination of LIAD and APPI provided a soft desorption and ionization technique that can allow detection of labile, low-polarity, structurally complex molecules over a wide mass range with minimal fragmentation.

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“…With the advent of soft ionization sources such as MALDI [2] and ESI [3], it has become possible to determine the intrinsic gas-phase properties of amino acids and other compounds of biological relevance in modern mass spectrometers [4 -11]. While it is now relatively straightforward to form protonated/deprotonated amino acids with these soft ionization sources, generating sufficient quantities of neutral amino acids for gas-phase equilibrium studies is still a challenge [6,12,13]. On the other hand, forming proton-bound dimer ions containing an amino acid and a reference compound for kinetic method experiments has become routine [5, 11, 14 -22].…”

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confidence: 99%

Proton affinity of β-oxalylaminoalanine (BOAA): Incorporation of direct entropy correction into the single-reference kinetic method

Wind

Papp

Happel

et al. 2005

J. Am. Soc. Mass Spectrom.

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A new version of the single-reference-extended kinetic method is presented in which direct entropy correction is incorporated. Results of calibration experiments with the monodentate base pyridine and the bidentate base ethylenediamine are presented for which the method provides proton affinities in excellent agreement with published values and reasonable predictions for the protonation entropies. The method is then used to determine the proton affinity and protonation entropy of the non-protein amino acid ␤-oxalylaminoalanine (BOAA). The PA of BOAA is found to be 933.1 Ϯ 7.8 kJ/mol and a prediction for the protonation entropy of -39 J mol -1 K -1 is also obtained, indicating a significant degree of intramolecular hydrogen bonding in the protonated form. These results are supported by hybrid density functional theory calculations at the B3LYP/6-311ϩϩG**//B3LYP/6-31ϩG* level. They indicate that the preferred site of protonation is the ␣-nitrogen atom (PA ϭ 935.0 kJ/mol) and that protonated BOAA has a strong hydrogen bond between the hydrogen on the ␣-amino group and one of the carbonyl oxygen atoms on the side chain. (J Am Soc Mass Spectrom 2005, 16, 1151-1161

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Laser-induced acoustic desorption/chemical ionization in Fourier-transform ion cyclotron resonance mass spectrometry

Cited by 72 publications

References 41 publications

Experimental Investigations of the Internal Energy of Molecules Evaporated via Laser-Induced Acoustic Desorption into a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer

Experimental Investigations of the Internal Energy of Molecules Evaporated via Laser-Induced Acoustic Desorption into a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer

Laser-Induced Acoustic Desorption Atmospheric Pressure Photoionization via VUV-Generating Microplasmas

Proton affinity of β-oxalylaminoalanine (BOAA): Incorporation of direct entropy correction into the single-reference kinetic method

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