Nitrogen-vacancy (NV) center is one type of special defects in diamonds. NV center not only can be used as sensors for temperature, stress detection, magnetic field, etc., but also has potential applications for quantum computing due to its unique physical properties. Therefore, the growth of diamond and creation of NV centers are significant for the future technologies. In this chapter, some methods for growing diamond thin film are introduced first, including traditional high-pressure-high-temperature (HPHT) and chemical vapor deposition (CVD) methods. The second part will focus on the current commonly used approaches to create NV centers. Inter-growth and post-growth processes are mainly utilized for the creation of NV centers during and after the growth of thin film, respectively.