Laser Interstitial Thermal Therapy in Grade 2/3 IDH1/2 Mutant Gliomas: A Preliminary Report and Literature Review

Johnson, Gabrielle W.; Han, Rowland H.; Smyth, Matthew D.; Leuthardt, Eric C.; Kim, Albert H.

doi:10.3390/curroncol29040209

Cited by 7 publications

(5 citation statements)

References 41 publications

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“…This is the first study to investigate the prognosis of patients with IDH1/2 mutated glioma after LITT. Our findings suggest that LITT is an effective option for the treatment of IDH1/2 mutant gliomas ( 21 ). It has also been reported that LITT-induced hyperthermia may have a synergistic effect with ionizing radiation, or may disrupt the BBB and facilitate the delivery of chemotherapy ( 23 , 29 ).…”

Section: Laser-induced Thermal Therapy Of Tumormentioning

confidence: 70%

“…Laser-induced thermal therapy (LITT) is a minimally invasive surgical approach based on thermal ablation provided by laser via flexible conductive fibers, acting by external or interstitial radiation ( 20 , 21 ) ( Figures 3 , 4 ). During the last 30 years, LITT has gained attention in various clinical scenarios, such as liver cancer, lung cancer, brain tumors, and recurrent or advanced head and neck tumors, among others.…”

Section: Laser-induced Thermal Therapy Of Tumormentioning

confidence: 99%

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Current status and research progress of minimally invasive treatment of glioma

Wu,

Zhou,

Gao

et al. 2024

Front. Oncol.

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Glioma has a high malignant degree and poor prognosis, which seriously affects the prognosis of patients. Traditional treatment methods mainly include craniotomy tumor resection, postoperative radiotherapy and chemotherapy. Although above methods have achieved remarkable curative effect, they still have certain limitations and adverse reactions. With the introduction of the concept of minimally invasive surgery and its clinical application as well as the development and progress of imaging technology, minimally invasive treatment of glioma has become a research hotspot in the field of neuromedicine, including photothermal treatment, photodynamic therapy, laser-induced thermal theraphy and TT-Fields of tumor. These therapeutic methods possess the advantages of precision, minimally invasive, quick recovery and significant curative effect, and have been widely used in clinical practice. The purpose of this review is to introduce the progress of minimally invasive treatment of glioma in recent years and the achievements and prospects for the future.

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Section: Laser-induced Thermal Therapy Of Tumormentioning

confidence: 70%

Section: Laser-induced Thermal Therapy Of Tumormentioning

confidence: 99%

Current status and research progress of minimally invasive treatment of glioma

Wu,

Zhou,

Gao

et al. 2024

Front. Oncol.

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“… The patient demographic data and characteristics from the 22 included studies differentiated by tumor type (GBM or astrocytoma). *: Johnson et al [ 53 ] is reported twice for independent astrocytoma grades, the first representing two patients with astrocytoma grade 2 and the second with three patients with astrocytoma grade 3. †: Murayi et al [ 56 ] is reported twice for two independent tumor type cohorts: the first reports astrocytoma and the second reports only GBM patients from the same study.…”

Section: Figurementioning

confidence: 99%

Safety and Efficacy of Laser Interstitial Thermal Therapy as Upfront Therapy in Primary Glioblastoma and IDH-Mutant Astrocytoma: A Meta-Analysis

Pandey,

Chandla,

Mekonnen

et al. 2024

Cancers

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Although primary studies have reported the safety and efficacy of LITT as a primary treatment in glioma, they are limited by sample sizes and institutional variation in stereotactic parameters such as temperature and laser power. The current literature has yet to provide pooled statistics on outcomes solely for primary brain tumors according to the 2021 WHO Classification of Tumors of the Central Nervous System (WHO CNS5). In the present study, we identify recent articles on primary CNS neoplasms treated with LITT without prior intervention, focusing on relationships with molecular profile, PFS, and OS. This meta-analysis includes the extraction of data from primary sources across four databases using the Covidence systematic review manager. The pooled data suggest LITT may be a safe primary management option with tumor ablation rates of 94.8% and 84.6% in IDH-wildtype glioblastoma multiforme (GBM) and IDH-mutant astrocytoma, respectively. For IDH-wildtype GBM, the pooled PFS and OS were 5.0 and 9.0 months, respectively. Similar to rates reported in the prior literature, the neurologic and non-neurologic complication rates for IDH-wildtype GBM were 10.3% and 4.8%, respectively. The neurologic and non-neurologic complication rates were somewhat higher in the IDH-mutant astrocytoma cohort at 33% and 8.3%, likely due to a smaller cohort size.

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“…Another significant application of LITT is the management of medically refractory epilepsy. The ability of LITT to precisely target epileptogenic foci has resulted in reduced seizure frequency and severity, showcasing its utility across various epileptic pathologies (Johnson et al, 2022). This advancement represents a significant step forward in epilepsy treatment, particularly for patients who do not respond to conventional medical therapies.…”

Section: Clinical Applications and Efficacymentioning

confidence: 99%

“…LITT has emerged as a transformative, minimally invasive technique for the treatment of various intracranial lesions, including brain tumors and other abnormalities (Johnson et al, 2022). This innovative approach uses laser energy delivered through a slender probe to induce thermal damage and coagulative necrosis in targeted lesions (Salem et al, 2019).…”

Section: Overview Of Studies On Littmentioning

confidence: 99%

The Applications of Laser Interstitial Thermal Therapy and Machine Learning in Neurosurgery: A Systematic Review

Bouras,

Patel,

Chetla

2023

Preprint

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BackgroundThe incorporation of Machine Learning (ML) into Laser Interstitial Thermal Therapy (LITT) represents a significant advancement in minimally invasive neurosurgery, particularly for treating brain tumors, vascular malformations, and epileptogenic foci. This systematic review focuses on evaluating the integration and impact of ML in enhancing the efficacy, precision, and outcomes of LITT in neurosurgical procedures.MethodsAn exhaustive search was conducted in major scientific databases for studies from 2015 to 2023 that specifically focused on the application of ML in LITT. The review assessed the development and implementation of ML algorithms in surgical planning, outcome prediction, and postoperative evaluation in LITT. Rigorous inclusion criteria were applied to select studies, and a combination of meta-analysis and qualitative synthesis was used to analyze the data.ResultsThe review synthesizes findings from a range of studies, including retrospective analyses and initial clinical trials. It highlights the role of ML in enhancing the selection criteria for LITT, optimizing surgical approaches, and improving patient-specific outcome predictions. While LITT showed favorable results in treating non-resectable lesions, the integration of ML was found to potentially refine these outcomes further. However, challenges such as the need for larger sample sizes, standardization of ML algorithms, and validation of these methods in clinical settings were noted.ConclusionsThe integration of ML into LITT procedures marks a promising frontier in neurosurgery, offering potential improvements in surgical accuracy and patient outcomes. The evidence suggests a need for continued development and rigorous testing of ML applications in LITT. Future research should focus on the refinement and validation of ML algorithms for wider clinical adoption, ensuring that technological advancements align with patient safety and treatment efficacy.

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Laser Interstitial Thermal Therapy in Grade 2/3 IDH1/2 Mutant Gliomas: A Preliminary Report and Literature Review

Cited by 7 publications

References 41 publications

Current status and research progress of minimally invasive treatment of glioma

Current status and research progress of minimally invasive treatment of glioma

Safety and Efficacy of Laser Interstitial Thermal Therapy as Upfront Therapy in Primary Glioblastoma and IDH-Mutant Astrocytoma: A Meta-Analysis

The Applications of Laser Interstitial Thermal Therapy and Machine Learning in Neurosurgery: A Systematic Review

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